京都大学 / 0048 / 新制・課程博士 / 博士(理学) / 甲第22279号 / 理博第4593号 / 新制||理||1659(附属図書館) / 京都大学大学院理学研究科生物科学専攻 / (主査)教授 本川 雅治, 准教授 中野 隆文, 教授 曽田 貞滋 / 学位規則第4条第1項該当 / Doctor of Science / Kyoto University / DGAM

The main objective of this thesis is an analysis of assessment techniques face, and cephalometric evaluation methods that are suitable for treatment of jaw position and design methods for treatment of jaw. At the same time the emphasis is on studying the methods,java advance imaging, which are used for the curvature of the image and should be able to meet the objectives of the assignment. These adjustments can be made using the Warp. Result of this work is an application developed in JAVA programming language, which demonstrates the best method for modifying the image. This method is WarpGrid. The application was made in the development environment eclipse. With this application, depending on the mouse action is possible to modify the image.

Les problèmes inverses de localisation de sources en électroencéphalographie (EEG) consistent à retrouver le lieu d'origine dans le cerveau des signaux mesurés sur le scalp. La qualité du résultat de localisation dépend des modèles géométriques et de conductivité électrique utilisés pour la résolution du problème. Parmi les tissus composant la tête, le crâne est celui dont la conductivité est la plus influente, en particulier à cause de sa faible valeur. De plus, le crâne humain est un tissu osseux comportant des parties dures et spongieuses, d'épaisseurs variables. Sa composition est très variable selon les individus, en termes de géométrie et de valeurs des conductivités, d'où la nécessité de développer des technique d'estimation de conductivités inconnues dans le crâne. Le but de cette thèse est de réduire l'incertitude sur la conductivité du crâne, pour des géométries sphériques et réalistes, en particulier en vue d’améliorer les résultats d'estimation des sources dans le problème inverse EEG. Dans le cas d'un domaine sphérique à 3 couches, l'existence, l'unicité et la stabilité de la conductivité dans la couche intermédiaire (crâne) sont discutées, et une procédure de reconstruction est proposée. Puis deux modèles plus réalistes de tête sont étudiés, l'un pour lequel le crâne est modelisé par un seul compartiment, l'autre dans lequel les parties spongieuses et dure sont distinguées. Des simulations numériques mettent en évidence le rôle de la structure interne du crâne pour la détermination de sa conductivité. / One of the major issues related to electroencephalography (EEG) is to localize where in the brain signals are generated, this is so called inverse problem of source localization. The quality of the source localization depends on the accuracy of the geometry and the electrical conductivity model used to solve the problem. Among the head tissues, the skull conductivity is the one that influences most the accuracy of the source localization, due to its low value. Moreover, the human skull is a bony tissue consisting of compact and spongy bone layers, whose thickness vary across the skull. As the skull tissue composition has strong inter-individual variability both in terms of geometry and of individual conductivity, conductivity estimation techniques are required in order to determine the unknown skull conductivity. The aim of this thesis is to reduce the uncertainty on the skull conductivity both in spherical and realistic head geometries in order to increase the quality of the inverse source localization problem. Therefore, conductivity estimation is first performed on a 3-layered spherical head model. Existence, uniqueness and stability of the conductivity in the intermediate skull layer are discussed, together with a constructive recovery scheme. Then a simulation study is performed comparing two realistic head models, a bulk model where the skull is modelled as a single compartment and a detailed one accounting for the compact and spongy bone layers, in order to determine the importance of the internal skull structure for conductivity estimation in EEG.

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京都大学 / 0048 / 新制・課程博士 / 博士(理学) / 甲第19265号 / 理博第4120号 / 新制||理||1593(附属図書館) / 32267 / 京都大学大学院理学研究科生物科学専攻 / (主査)教授 濱田 穣, 准教授 平﨑 鋭矢, 教授 中村 克樹 / 学位規則第4条第1項該当 / Doctor of Science / Kyoto University / DFAM

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This thesis presents two studies related to head injury. The study presented in Chapter 1 reviewed findings of cranial movement in animal and human specimens and evaluate the validity of cranial movement due to manual manipulation in humans through engineering analysis. The study had two parts. In Part I, the literature was reviewed to determine the cranial motion in animals and humans. Engineering analysis was done in Part II to determine the amount of force necessary to cause cranial motion in the studies from Part I using skull stiffness values from published studies. Chapter 2 explored data collection methodologies used in frontal sled tests. Several data collection methodologies exist for collecting kinematic data, such as Vicon motion analysis, video analysis, and sensors. Head trajectories from motion data and accelerometer data were plotted up to maximum forward excursion of the head for eight frontal sled tests, four conducted at Virginia Tech and four at the University of Virginia. In addition, the percent difference between maximum forward excursion values from sensor and motion data were calculated. Finally, Chapter 3 discusses the literary contributions of each study and to which journals they will be submitted. / Master of Science

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