The functions of sleep remain enigmatic. One of the dominant, yet more contentious hypotheses is that sleep is involved in memory consolidation. A large body of evidence supports the role of rapid eye movement (REM) sleep in memory consolidation, especially in rodents. In humans, the role of REM sleep in memory consolidation has also been investigated, however it is unclear if it supports only one type of memory, or consolidation for several memory systems. Recent evidence suggests that non-REM is also involved in memory consolidation. The role of theta activity during REM and sleep spindles during non-REM may provide electrophysiological signatures reflecting memory consolidation processes. The studies presented here attempt to further investigate the electrophysiological characteristics of the learning-dependent changes in REM and slow wave sleep (SWS) in rats. A 2-stage model of memory consolidation is outlined here, and both steps of the model were investigated. Consistent with previous studies, REM increases were observed following avoidance training. During this period, theta power during REM sleep was increased compared to non-learning rats. Increased sleep spindle density during SWS was observed following REM increases. When REM sleep was suppressed by infusing the GABAB agonist baclofen into the pedunculopontine nucleus, avoidance performance acquisition was impaired. Baseline sleep spindles predicted whether rats were able to learn to make avoidance responses. Results suggest that both REM and SWS may be sequentially involved in memory consolidation processes. Discrete periods (windows) exist for REM and SWS when memory consolidation processes appear to take place. Theta activity during REM sleep from 17- 20 h on the first post-training day and sleep spindles during SWS from 21-24 h on the first post- training day are increased in learning rats and are related to memory performance. / Thesis (Ph.D, Neuroscience Studies) -- Queen's University, 2009-10-26 12:07:47.515

Made available in DSpace on 2014-12-17T14:56:17Z (GMT). No. of bitstreams: 1 EdsonAMRB_DISSERT.pdf: 7502344 bytes, checksum: 78d70443ae2fd9033fe78b23c5cbd811 (MD5) Previous issue date: 2013-07-30 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / Complex network analysis is a powerful tool into research of complex systems like brain networks. This work aims to describe the topological changes in neural functional connectivity networks of neocortex and hippocampus during slow-wave sleep (SWS) in animals submited to a novel experience exposure. Slow-wave sleep is an important sleep stage where occurs reverberations of electrical activities patterns of wakeness, playing a fundamental role in memory consolidation. Although its importance there s a lack of studies that characterize the topological dynamical of functional connectivity networks during that sleep stage. There s no studies that describe the topological modifications that novel exposure leads to this networks. We have observed that several topological properties have been modified after novel exposure and this modification remains for a long time. Major part of this changes in topological properties by novel exposure are related to fault tolerance / A an?lise da topologia de redes ? uma poderosa ferramenta no estudo de sistemas complexos tal como as redes cerebrais. Este trabalho procura descrever as mudan?as na topologia de redes de conex?o funcional em neur?nios do c?rtex sensorial e do hipocampo durante o sono de ondas lentas (SWS) em animais expostos ? novidade. O sono de ondas lentas ? um importante estado do sono onde h? reverbera??o de padr?es de atividade el?trica ocorridos na vig?lia, tendo com isso papel fundamental na consolida??o de mem?ria. Apesar de sua import?ncia ainda n?o h? estudos que caracterizam a din?mica da topologia de redes de conex?o funcional durante este estado. Tampouco h? estudos que descrevem as modifica??es topol?gicas que a exposi??o ? novidade traz a essas redes. Observamos que v?rias propriedades topol?gicas s?o modificadas ap?s a exposi??o ? novidade e que tais modifica??es se mant?m por um longo per?odo de tempo. A maior parte das propriedades modificadas pela exposi??o ? novidade est? relacionada ? toler?ncia ? falha