As organizations rely heavily on innovative knowledge from the academic research results, there is a growing need to implement an IT platform which can facilitate knowledge acquisition, assimilation and exploitation for practitioners. Recently National science council Taiwan has launched a project to develop the eTop (Engineering and Technology Promotion) platform which allows researchers to upload their research results and practitioners to browse the available research results based on their needs. In order to enhance the operation performance of the eTop, there is a need to investigate its business strategy. To address this issue, we followed the case study method to analyze the eTop context and provide suggestions. First, we clearly portray the eTop business model, and then we proposed a set of business strategies for eTop operation based on Metcalf¡¦s Law, social media capabilities and intensive interview with eTop platform developers, researchers and practitioners. With these proposed strategies, the eTop managing team can have better understanding and preparation for eTop operation, and thereby enhance the effectiveness of knowledge acquisition, assimilation and exploitation for practitioners.