The goal of this master's thesis is creating a concept of architecture for new information system of the Academic Center for Students Activities. New information system of the Academic Center should be well documented and better maintainable. The first part deals with software maintenance and software architecture design. The second part contains analysis of current information system of Academic Center for Students Activities and also the architecture of new system is designed. The next parts are design of framework for the new system and also design of particular modules. Then there are implementation of designed parts and testing on real data.

Hadron Therapy (HT) exploits properties of ion radiation to gain therapeutic advantages over existing photon-based forms of external radiation therapy. However, its relative superiority and cost-effectiveness have not been proven for all clinical situations. Establishing a robust evidence base for the development of best treatment practices is one of the major challenges for the field. This thesis investigates two research infrastructures for building this essential evidence. First, the thesis develops main components of a metadata-driven software architecture for the collection of clinical information and its analysis. This architecture acknowledges the diversity in the domain and supports data interoperability by sharing information models. Their compliance to common metamodels guarantees that primary data and analysis results can be interpreted outside of the immediate production context. This is a fundamental necessity for all aspects of the evidence creation process. A metamodel of data capture forms is developed with unique properties to support data collection and documentation in this architecture. The architecture's potential to support complex analysis processes is demonstrated with the help of a novel metamodel for Markov model based simulations, as used for the synthesis of evidence in health-economic assessments. The application of both metamodels is illustrated on the example of HT. Since the biological effect of particle radiation is a major source of uncertainty in HT, in its second part, this thesis undertakes first investigations towards a new research facility for bio-medical experiments with ion beams. It examines the feasibility of upgrading LEIR, an existing accelerator at the European Organisation for Nuclear Research (CERN), with a new slow extraction and investigates transport of the extracted beam to future experiments. Possible configurations for the slow-resonant extraction process are identified, and designs for horizontal and vertical beam transport lines developed. The results of these studies indicate future research directions towards a new ion beam facility for biomedical research.

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An important characteristic of Service-Oriented Architectures is that clients do not depend on the service implementation's internal assignment of methods to objects. It is perhaps the most important technical characteristic that differentiates them from more common object-oriented solutions. This characteristic makes clients and services malleable, allowing them to be rearranged at run-time as circumstances change. That improvement in malleability is impaired by requiring clients to direct service requests to particular services. Ideally, the clients are totally oblivious to the service structure, as they are to aspect structure in aspect-oriented software. Removing knowledge of a method implementation's location, whether in object or service, requires re-defining the boundary line between programming language and middleware, making clearer specification of dependence on protocols, and bringing the transaction-like concept of failure scopes into language semantics as well. This paper explores consequences and advantages of a transition from object-request brokering to service-request brokering, including the potential to improve our ability to write more parallel software.