Syfte: Syftet var att undersöka det vetenskapliga kunskapsläget beträffande transpersoners utsatthet för partnervåld med avseende på våldets karaktär samt för transpersoners särskilda utsatthet och tillgång till stöd. Metod: Genom utförandet av en scoping review inkluderades tretton artiklar som analyserades utifrån innehållsanalys (manifest och latent). Resultat: Analysen resulterade i tre huvudteman med tillhörande underteman, (1) partnervåld i samband med transidentitet; transpecifikt partnervåld, psykiskt partnervåld, (2) särskild utsatthet i samband med partnervåld; samhällsnormer, ytterligare riskfaktorer, (3) stöd från samhället och närstående; formellt stöd från samhället, informellt stöd från närstående, normativa roller för offer och förövare. Slutsats: Förekomsten av partnervåld bland transpersoner var omfattade och det fanns särskilda omständigheter som många gånger var kopplad till offrets transidentitet. Därmed uppstår ett behov av att transspecifika stödresurser utformas, samtidigt som professionellas kunskap och förståelse om målgruppen behöver öka. / Purpose: The aim was to explore the current state of knowledge within scientific research regarding transgender people’s exposure to intimate partner violence. Moreover to study the structure of the violence, transgender specific vulnerabilities and access to support. Method: Through scoping review, thirteen scientific articles were included and analyzed through content analysis (manifest and latent). Results: Three main themes emerged with appurtenant sub-themes, (1) intimate partner violence in relation to trans identity; transspecific intimate partner violence, psychological intimate partner violence, (2) specific vulnerabilities inrelation to intimate partner violence; societal norms, additional risk factors, (3) Support from society and personal network; formal support from society, informal support from personal network, normative roles for victims and perpetrators. Conclusion: Prevalence of intimate partner violence was extensive among transgender people, specific circumstances emerged related to the victims trans identity, which calls for transspecific support services and increased knowledge of the target group amongst professionals.

Syfte: Syftet var att undersöka det vetenskapliga kunskapsläget beträffande transpersonersuts atthet för partnervåld med avseende på våldets karaktär samt för transpersoners särskilda utsatthet och tillgång till stöd. Metod: Genom utförandet av en scoping review inkluderades tretton artiklar som analyserades utifrån innehållsanalys (manifest och latent). Resultat: Analysen resulterade i tre huvudteman med tillhörande underteman, (1) partnervåld i samband med transidentitet; transpecifikt partnervåld, psykiskt partnervåld, (2) särskild utsatthet i samband med partnervåld; samhällsnormer, ytterligare riskfaktorer, (3) Stöd från samhället och närstående; formellt stöd från samhället, informellt stöd från närstående, normativa roller för offer och förövare. Slutsats: Förekomsten av partnervåld bland transpersoner var omfattade och det fanns särskilda omständigheter som många gånger var kopplad till offrets transidentitet. Därmed uppstår ett behov av att transspecifika stödresurser utformas, samtidigt som professionellas kunskap och förståelse om målgruppen behöver öka. / Purpose: The aim was to explore the current state of knowledge within scientific research regarding transgender people’s exposure to intimate partner violence. Moreover to study the structure of the violence, transgender specific vulnerabilities and access to support. Method:Through scoping review, thirteen scientific articles were included and analyzed through content analysis (manifest and latent). Results: Three main themes emerged with appurtenant sub-themes, (1) intimate partner violence in relation to trans identity; transspecific intimate partner violence, psychological intimate partner violence, (2) specific vulnerabilities in relation to intimate partner violence; societal norms, additional risk factors, (3) Support from society and personal network; formal support from society, informal support from personal network, normative roles for victims and perpetrators. Conclusion: Prevalence of intimate partner violence was extensive among transgender people, specific circumstances emerged related to the victims trans identity, which calls for transspecific support services and increased knowledge of the target group amongst professionals.

During the past few decades, the landscape of available therapeutic interventions for cancer treatment has widely expanded, boosted mainly by immunotherapy progress and the precision oncology paradigm. The extensive use of pre-clinical models in cancer research has led to the discovery of new effective treatment options for patients. Despite the notable advancements, some cancer types have found minor benefits from the use of precision-oncology interventions. Characterized by a heterogeneous molecular landscape, bladder cancer is one of the most frequent cancer types in which standard-of- care treatments involve surgical operations accompanied by broad-spectrum chemotherapy. My research stems from the need for precision oncology interventions in bladder cancer and specifically focuses on the development of computational frameworks to guide the discovery of new therapeutic opportunities. This work first introduces the exploration of possible therapeutic interventions in 9p21.3 depleted bladder tumors through the analysis of an in-house large High-Content Drug Screening that tested 2,349 compounds. By combining cell count changes and morphological quantitative features extracted from fluorescence images, we nominate cytarabine as a putative candidate eliciting specific cytotoxic effects in an engineered 9p21.3 depleted bladder cancer model compared to an isogenic wild-type clone. Focusing on the development of computational methodologies to nominate robust context-specific vulnerabilities, I further describe PRODE (PROtein interactions informed Differential Essentiality), an analytical workflow that integrates protein-protein interaction data and Loss of Function screening data. I extensively tested PRODE against the most commonly used and alternative methodologies and demonstrated its superior performance when classifying reference essential and context-essential genes collected from experimental and literature sources. Furthermore, we applied PRODE to a real case scenario, seeking essential genes selectively in the context of HER2+ Breast Cancer tumors. Finally, I report the computational analyses performed on Patient-Derived Organoids (PDOs) established from a bladder cancer cohort. PDOs are demonstrated as informative models when assessing the therapeutic sensitivity of patients to drugs. Overall, this research highlights novel precision-oncology applications by ad-hoc computational analyses that address key open technical and biological challenges in the field of bladder cancer and beyond.