This study investigated the spatial distribution and seasonal variation of pharmaceuticals and personal care products (PPCPs) and illicit drugs in western Hengchun peninsula and Kenting coastal tourist area in Taiwan. We used solid phase extraction (SPE) followed by liquid-chromatography tandem mass spectrometry (HPLC-MS/MS) to determine 22 PPCPs and 10 illicit drugs in water samples. The detected concentrations of PPCPs and illicit drugs ranged from below detection limit to 9350 ng/L, and the most frequently five detected compounds in this area were ampicillin (79%), codeine (63%), caffeine (62%), carbamazepine (61%) and pseudoephedrine (57%). The impact of the special event- Kenting music festival, such as ¡§spring scream¡¨ was also discussed in this study, and the results from PCA and HCA both showed that the concentrations and distributions of PPCPs and illicit drugs were affected by the tourists. In addition, two wastewater treatments plants (WWTPs) were also investigated for seven days during Kenting music festival period. The results indicated that WWTPs did not show enough removal efficiencies in Kenting tourist area during the special event. The impact of the PPCPs and illicit drugs to the aquatic environment and ecology still needs to be further monitored.