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Mothers and microscopes, fathers and flasks : how parents and schools contribute to Latina adolescents' interest in STEMJackson, Karen Denise Moran 26 July 2011 (has links)
The primary aim of this research study is to examine how contextual and psychological variables interact on the development of Latina adolescents’ interests in science, technology, engineering, and math (STEM). The literature review starts with an overview of career interest development theories and an identification of key common factors. The major factors of parent socialization and the social constructions of gender and ethnicity are then discussed with particular emphasis on how they may influence interest development for middle school Latina students. This section concludes with an investigation into differences in access to school science and math resources, an environmental factor that also impacts development. The final section proposes a quantitative analysis that will address various questions raised in the literature review. The proposed study consists of correlations and linear regressions, controlling for background variables, as well as investigating interactions between identified factors. / text
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Hepatitis B infection and hematopoietic stem cell transplantationLau, Ka-kit, George., 廖家傑. January 1999 (has links)
published_or_final_version / Medicine / Master / Doctor of Medicine
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Over-expression of epidermal growth factor precursor in vitro and in vivo關永寶, Kwan, Wing-po, Rainbow. January 1998 (has links)
published_or_final_version / Paediatrics / Master / Master of Philosophy
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Collagen gene expression in embryonic stem cells and in mouse development劉嚴德光, Lau Yim, Tak-kwong, Elizabeth. January 1991 (has links)
published_or_final_version / Biochemistry / Doctoral / Doctor of Philosophy
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HUGL and the Role of Polarity in Breast CancerRuss, Atlantis Dawn January 2013 (has links)
Loss of polarity is a defining characteristic of epithelial cancers. The cytoskeletal proteins, HUGL1 and HUGL2, mediate polarity in epithelial cells through diversified roles in defining membrane identity and trafficking to the basolateral membrane. Importantly, an ortholog of these molecules can inhibit tumor growth in Drosophila, although the mechanisms of their tumor suppressive functions in mammary epithelial cells are unknown. Here, we show nonredundant tumor protective roles for HUGL1 and HUGL2 in human mammary epithelial cells. Using a three dimensional culture system, we report that loss of HUGL1 or HUGL2 causes loss of apicobasal polarity, aberrant growth of multilayered epithelium, nuclear enlargement, loss of membrane identity, and cellular overgrowth. Experiments on plastic also revealed that HUGL1 or HUGL2 loss results in induction of a phenotypic EMT in breast epithelial cells and overexpression of HUGL1 in breast cancer cells reduces proliferation.In a Drosophila model of cancer driven by loss of lgl, we have discovered the consistent dysregulation of a number of miRNAs and mRNAs including the loss of let-7 and miR-9a, which are implicated in breast cancer and associated with the suppression of stem cells. Cross comparisons revealed a set of mRNAs that are both dysregulated in vivo and represent putative targets of the miRNAs changed in lgl mutants. Among these, Thrombospondin, a component of the extracellular matrix was found to be misexpressed in both flies and human cells lacking Lgl. Moreover, genetic interaction experiments showed miR-9a to be a functional effector of lgl in controlling proliferation in the wing. Taken together, the findings reported in this dissertation suggest that HUGL1 and HUGL2 function as tumor suppressors through their roles in polarity and miRNA regulation. These two proteins, functioning as modulators of cell plasticity and promoters of differentiation, are potentially able to control the transition between a differentiated epithelial cell and a cancer stem cell. This research offers new insight into the role of HUGL1 and HUGL2 in breast cancer and reveals novel targets downstream of polarity proteins for therapeutic intervention.
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Using human embryonic stem cells to model acute brain injuryGupta, Kunal January 2012 (has links)
No description available.
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Human induced pluripotent stem cells for in vitro modeling and cell based therapy of α-1 antitrypsin deficiencyRashid, Sheikh Tamir January 2012 (has links)
No description available.
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Genomic imprinting in mouse pluripotent stem cellsSun, Bowen January 2011 (has links)
No description available.
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Transcriptional characterization of glioma neural stem cellsTommei, Diva January 2013 (has links)
No description available.
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Cell cycle kinetics of mammary stem and progenitor cellsGiraddi, Rajashekharagouda January 2013 (has links)
No description available.
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