Objective: In patients with Parkinson’s disease (PD), deep brainstimulation of the subthalamic nucleus (STN DBS) is well recognizedin improving limb function, but the outcome on swallowing functionhas rarely been studied. The aim of this work was to evaluate theeffect of STN DBS on pharyngeal swallowing function in patientswith PD using self-estimation and fiberoptic endoscopic evaluation ofswallowing. Methods: Eleven patients (aged 41–72, median 61 years)were evaluated preoperatively and at 6 and 12 months after STN DBSsurgery. All patients were evaluated with self-estimation on a visualanalogue scale, and eight of them with a fiberoptic endoscopicexamination with a predefined swallowing protocol includingRosenbek’s Penetration-Aspiration Scale, Secretion Severity Scale,preswallow spillage, pharyngeal residue, and pharyngeal clearance. Results: The self-assessments of swallowing function revealed asubjective improvement with STN DBS stimulation, whereas the datafrom the swallowing protocol did not show any significant effect ofthe STN DBS treatment itself. The prevalence of aspiration was notaffected by the surgery. Conclusions: The results show thatswallowing function was not negatively affected by STN DBS and therisk of aspiration did not increase. Self-estimation of swallowingfunction showed a subjective improvement due to stimulation / Speech, voice and swallowing outcomes after deep brain stimulation (DBS)

Larynxcancer är den tredje vanligaste formen av huvud- och halscancer och drabbar cirka 175 personer årligen i Sverige. En vanlig behandlingsmetod vid larynxcancer är strålbehandling. Detta är en retrospektiv journalstudie med syfte att undersöka hur svälj- och röstfunktion samt nutritionsstatus påverkas av strålbehandling för larynxcancer. Studiens syfte är även att undersöka om det finns något samband mellan tumörgrad och sväljförmåga efter avslutad behandling samt om och när svälj- och röstfunktion återhämtas. Studien har även undersökt andelen patienter som erbjudits logopedkontakt. I studien har 52 patienter med larynxcancer (C.32) inom region Gävleborg inkluderats. Resultaten indikerar att strålbehandling påverkar svälj- och röstfunktion samt nutritionsstatus. Vid strålavslut hade 24 av 48 patienter tecken på sväljsvårigheter och 33 av 52 patienter hade en påverkan på röstfunktionen. Under behandlingen noterades ett ökat behov av näringsdryck och 24 av 37 deltagare gick ner i vikt under eller efter behandling vilket indikerar nutritionssvårigheter. Andelen patienter som var i behov av enteral nutrition vid strålavslut var 7 av 52 patienter. Sammanlagt erbjöds 33 av 52 patienter logopedkontakt. Återhämtning av sväljfunktionen rapporterades hos 22 av 39 patienter inom ett år efter avslutad strålbehandling. Återhämtning av röstfunktionen noterades hos 8 av 40 patienter inom fem år efter avslutad strålbehandling. Studiens resultat ger värdefull information om strålbehandlingens påverkan på livsviktiga funktioner och hoppas kunna bidra med underlag till prospektiva studier inom huvud- och halscancer. / Laryngeal cancer is the third most common form of head- and neck cancer and each year approximately 175 people receive the diagnosis in Sweden. Radiotherapy is a common treatment against laryngeal cancer. This is a retrospective cohort study, and it has investigated how swallowing, voice function and nutritional status can be affected by radiotherapy. The aim of the study was to explore whether there is a correlation between the grade of tumor and swallowing after treatment and when swallowing and voice function recover. The aim was also to research how many patients received contact with a speech- and language pathologist before or during treatment. The following study included 52 patients with laryngeal cancer (C.32) within the region of Gävleborg, Sweden. The results indicate that radiotherapy affects swallowing, voice function, and nutritional status. By the end of treatment, 24 of 48 patients had signs of dysphagia and voice function was affected in 33 of 52 patients. An increase in the need for nutritional drinks was noted throughout radiotherapy and 24 of 37 patients lost weight during or after treatment, which indicates nutritional difficulties. At the end of the treatment, 7 of 52 patients needed enteral nutrition. In total, 33 of 52 patients were offered contact with a speech- and language pathologist. Recovery of the swallowing function was reported in 22 of 39 patients at some point during the first year after radiotherapy. Recovery of voice function was reported in 8 of 40 patients at some point during five years after radiotherapy. The results of the study indicates possible implications that radiotherapy might have on vital functions, and it can suffice as a basis for further prospective studies within the area of head- and neck cancer.