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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
11

Motion selectivity as a neural mechanism for encoding natural conspecific vocalizations

Andoni, Sari 07 February 2011 (has links)
Natural sound, such as conspecific vocalizations and human speech, represents an important part of the sensory signals animals and humans encounter in their daily lives. This dissertation investigates the neural mechanisms involved in creating response selectivity for complex features of natural acoustic signals and demonstrates that selectivity for spectral motion cues provides a neural mechanism to encode communication signals in the auditory midbrain. Spectral motion is defined as the movement of sound energy upward or downward in frequency at a certain velocity, and is believed to provide the auditory system with an important perceptual cue in the processing of human speech. Using the Mexican free-tailed bat, tadarida brasiliensis, as a model system, this research examined the role of selectivity for spectral motion cues, such as direction and velocity, in creating response selectivity for specific features of the social communication signals emitted by these animals. We show that auditory neurons in the midbrain nucleus of the inferior colliculus (IC) are specifically tuned for the frequency-modulated (FM) direction and velocities found in their conspecific vocalizations. This close agreement between neural tuning and features of natural conspecific signals shows that auditory neurons have evolved to specifically encode features of signals that are vital for the survival of the animal. Furthermore, we find that the neural computations resulting in selectivity for spectral motion are analogous to mechanisms observed in selectivity for visual motion, suggesting the evolution of similar neural mechanisms across sensory modalities. / text
12

L'Homme face à son environnement : une histoire génétique et épigénétique du génome humain / Humans in an adaptive world : genetic and epigenetic responses to environmental challenges

Fagny, Maud 29 June 2015 (has links)
Les populations humaines ont été confrontées à de nombreux changements environnementaux au cours de leur histoire et présentent aujourd’hui une grande diversité d’habitats et de modes de subsistance. Cependant, l’ampleur de l’adaptation génétique et des réponses épigénétiques à ces changements est débattue. Nous avons d’abord étudié la puissance de diverses statistiques pour détecter les balayages sélectifs dans le contexte des données de séquençage à haut débit, et évalué leur robustesse à différents facteurs confondants. En utilisant des jeux de données de séquençage, nous montrons que les balayages sélectifs ont eu un impact modéré mais non négligeable dans l’évolution récente du génome humain. Les régions sous sélection sont enrichies en mutations associées à des variations phénotypiques. Nous avons ensuite évalué l’impact respectif des facteurs génétiques et environnementaux sur la diversité épigénétique humaine. Pour cela, nous avons obtenu les génotypes et les profiles de méthylation de l’ADN de populations d’Afrique Centrale présentant des différences récentes d’habitat ou historiques de modes de vie et de profil génétique. Nous montrons que les deux facteurs ont un effet similaire sur le méthylome mais diffèrent par les fonctions biologiques affectées et les mécanismes expliquant les variations observées. Plus généralement, les variations de méthylation sont fortement associées à des mutations génétiques qui sont enrichies en signaux de sélection positive. En conclusion, ce travail apporte un aperçu de la contribution des mutations génétiques et des réponses épigénétiques à l’adaptation humaine aux changements environnementaux sur plusieurs échelles de temps. / Human populations have faced a large number of environmental challenges during their evolutionary history and present today a wide range of habitats and mode of subsistence. However, the extent of genetic adaptation and epigenetic responses to such environmental variation remains controversial. We first explored the power of several statistics to detect hard selective sweeps in the context of whole-genome sequencing data, and evaluated their robustness to demography and other selection modes. Using data from the 1,000 Genomes Project and Complete Genomics, we showed that hard sweeps targeting low-frequency standing variation have played a moderate, albeit significant, role in recent human evolution. The signals of selection detected were moreover enriched in functional variants detected by genome-wide association studies. We then evaluated the relative impacts of genetic and environmental factors on human epigenomic diversity. To do so, we generated genome-wide genetic and DNA methylation profiles for Central African populations differing in their current habitat or in their historical lifestyle and genetic background. We found that both factors have similar critical impacts on the shaping of the global methylome, but the biological functions affected and the mechanisms underlying DNA methylation variation strongly differ. More generally, methylation variation shows strong associations with nearby genetic variants that, moreover, are enriched in signals of natural selection. Together, this work provides new insight into the contribution of genetic adaptation and epigenetic responses to the adaptation of humans to environmental changes over different time scales.
13

Literary Activism: James Montgomery, Joanna Baillie, and the Plight of Britain’s Chimney Sweeps

Slagle, Judith Bailey 01 January 2012 (has links)
Excerpt: On 6 February 1824, Joanna Baillie Notified Her Friend Walter Scott that Scottish poet James Montgomery, then living in Sherrield, England, had written to ask her for a poem on the plight on chimney sweeps, also known as climbing boys.

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