After 2010, substances that have similar effects as opiate drugs and stimulant drugs started to appear in the Czech Republic as well as in other European countries and around the world, however they are not controlled by any legislation because of their "newness". The aim of this study is to evaluate whether under the current circumstances this is a problem that should be solved politically, including the assessment of its extent. The current solutions to this problem focused on its regulation shall be assessed on the basis of the results of this analysis. The thesis also aims to identify different perspectives of the drugs issue experts and to understand their involvement in the process of making the drug policy of the Czech Republic concerning these substances. The first part describes the current situation in the field of new psychoactive substances in the Czech Republic using a qualitative method of the documentary content analysis, and introduces the legislative approaches currently used at both national and international level. The research part employs the qualitative research methods (semi- structured interviews with experts in the field of drugs problems). The carried out research has found that the experts perceive new psychoactive substances as a problem whose extent however is not as intensive...

The goal of this thesis is to design and implement a program capable of automatically generating synthetic images of eye retinas. The generated images should be similar to those of real retinas, which are hard to obtain, so they could be used for development of various algorithms, which work with eye retina images in their place. This thesis describes anatomic properties of the eye retina, ways to take images of it and also usage of eye retina recognition in biometric and medicinal applications. Design of the program and the way in which individual parts of the retina are assembled together into the final image is also explained in this thesis. These individual parts are created using procedural textures in separate layers of the image. Next chapter of this work describes implementation details of the program. The conclusion then experimentally verifies suitability of the generated images for algorithmic processing.

Synthetic fragrances or MUSK compounds are artificialy synthetised organic substances, used as fragrant constituents in various homecare products, such as cosmetics, detergents, air fresheners etc. The aim of diploma thesis was the quantification of some selected MUSK compounds in the influent and efluent of the water treatment plants.The method of quantification of MUSK compounds in organic matrix was also optimised during the research. Two modifications of solid phase microextraction were tested and evaluated. The analytes were identified and quantified by gas chromatography - mass spectrometry (GC/MS). The results were used to evaluate the amount of MUSK compounds in sewage waters and the ability of various water treatment plants to eliminate this kind of pollution from the water during the treatment process.

One of the main objectives of family policies in countries with low fertility levels is to stimulate birth rates and incentivize the citizens to have more children. Nevertheless, the research on whether this objective is being met remains inconclusive. In this thesis, we analyze two reforms which took place in the Czech Republic in 1995 and 2008, which adjusted the period of reception of the parental allowance. We use data from selected European OECD countries along with the synthetic control approach to construct a synthetic counterpart to the Czech Republic which gives us an idea about how fertility levels would have developed if the interventions did not take place. In both cases, 1995 reform and 2008 reform, we do not find any conclusive evidence that the interventions affected fertility levels in the Czech Republic. Moreover, we observe a change in the trend of total fertility rate about 2 years before each reform which suggests that these reforms were more likely reactions to changing fertility rates rather than remedies. JEL Classification J13, J17, J11, J12, E61, E65, F68 Keywords fertility, family policy, synthetic control estimator, parental allowance, parental leave Author's e-mail 31609261@fsv.cuni.cz Supervisor's e-mail barbara.pertold-gebicka@fsv.cuni.cz

This thesis describes in the form of a commentary on own original publications research on the problems of cannabinoids, ie. phytocannabinoids and some synthetic cannabinoids, their pharmacokinetics and effects. The work consists of four thematic areas: the pharmacokinetics of delta-9- tetrahydrocannabinol (THC) and cannabidiol (CBD) in rats, depending on the route of administration; THC concentration time profile in humans (after inhalation) and implications for transport safety; the pharmacokinetic profile of synthetic cannabinoids in rats; extraction and determination of phytocannabinoids in plant material. The first part of the thesis was to determine pharmacokinetic profiles of THC, CBD and combination thereof (1:1 weight ratio) in rats with respect to administration common in humans, i.e. inhalation, oral and subcutaneous administration. THC, its metabolites (11-hydroxy-tetrahydrocannabinol, 11-OH-THC; 11-nor-delta-9- carboxytetrahydrocannabinol, THCOOH) and CBD concentrations in serum and brains of animals were monitored at the 24 hours experimental interval during the study. Except for inhalation administration, co-administration of CBD inhibited THC metabolism (after both oral and subcutaneous), resulting in an increase in THC concentrations in both serum and brain of the rats relative to...

New synthetic drugs are a new phenomenon that is expanding in many countries. NSD mimic the effects of traditional drugs phenomenological, but retain the hallmark of legal substances. NSD legal status is due to the fact that theses new substances are controlled by the United Nations Single Convention on Narcotic Drugs of 1961 or the UN Convention on Psychotropic Substances, 1971. To the Czech Republic this trend came somewhat later than in neighboring countries, and especially in 2010, when sales NSD was mainly in shops. This sale was completed in April 2011 becouse of entering 33th NSD to the list of psychotropic and narcotic substances and moved mostly to the internet. NSD composition is often changing, due to disabling preparatory material, it follows that the risks associated with the use of NSD are unpredictable. The research objective of this study is to determine the acquisition and distribution of NSD between problem drug users and also to map the most widely used NSD among this population.The main purpose of the research is to bring knowledge (as it's called, how it look, what it contains, where and from whom it receives, how much it costs). The survey was made up of semi-structures interviews (qualitative part) and structured questionnaires (quantitative part). Respondents were selected...

Introduction: Pelvic organ prolapse is a major health problem affecting 50% of parous women over the age of 50. The lifetime risk for pelvic floor surgery for prolapse is likely to be between 10 and 20% and a large number of patients require repeat surgery for recurrence. Cochrane review showed that mesh use at the time of anterior repair reduce the risk of recurrence. In our first study we prospectively evaluate the impact of mesh insertion during anterior repair on sexual function and quality of life. Mesh insertion may be associated with significant and in some cases serious adverse events. To justify its use, it seems necessary to identify women at high risk of prolapse recurrence. There is evidence indicating that levator ani avulsion injury is closely associated with prolapse recurrence. The aim of our second and main study was to demonstrate in a prospective randomized way that levator avulsion may be used to identify patients at high risk for failed native tissue prolapse surgery. Methods: The first study prospectively evaluated with validated questionnaires the impact of mesh insertion on quality of life and sexual function. The second study is a single-center, prospective, randomized interventional trial of two standard surgical procedures for post-hysterectomy vaginal vault prolapse in...

Critical infrastructure (CI) is one of the most important branches in crisis man-agement. In recent years, CI demonstrated its importance on many occasions. My work is focused on the analysis of risks which can be a possible threat to CI. This is because the most important part of securing CI is the prevention of, and prepara-tion for, interruptions or damage. The risks in this part were specified using a FRAP analysis. I also identify the main reciprocal dependencies of all CI sectors to demonstrate which sector is the most important one. Finally, I specify the process of recovering or restoring these CI sectors. A new method was intentionally used for analytical-synthetic models. This method, in conjunction with the use of a FRAP analysis, is new to the branch of crisis management and was used for first time. The main aim of my work is to improve knowledge about CI at a regional level {--} city of České Budějovice. I submit new ways of identifying risks and resolv-ing problems during the recovery phase {--} specialized in CI.

The work deals with the resistance of the VeriFinger comparison algorithm to synthetic fingerprints. The basics of fingerprints, comparison algorithms and synthetic fingerprint generators are gradually analyzed. In total, three experiments were designed to test the resistance of the algorithm using synthetic fingerprints. An application using the VeriFinger algorithm was implemented to evaluate individual experiments. A total of 2 800 000 synthetic fingerprints were generated across all experiments. The first experiment showed that random fingerprint generation was not effective for real fingerprints, but was somewhat sufficient for synthetic fingerprints. The second experiment proved that comparison and the comparison score could be used to estimate the class of the identified fingerprint, and in the third experiment, by narrowing the generation to one class, it raised the total number of matched fingerprints. The results of individual experiments were written and their possible extension was suggested.

Synthetic fragrances (musk) are artificially produced organic compounds. It is used as fragrance ingredient in personal care products. Substances from this group have the ability to withstand the cleaning process in wastewater treatment plants. The physico-chemical properties of musk compounds cause their accumulation in the living and non-living components of the ecosystem, where they behave as persistent pollutants. The adsorption process is considered to be one of the most widely used separation and purification processes. The adsorption processes of a solution of sixteen synthetic fragrances took place with biochar and activated carbon. Solid phase microextraction (SPME) was used as a method for extracting analytes. Gas chromatography coupled with mass spectrometry (GC-MS) was applied for final analysis, time of flight analyzer was used as detector. The data were fitted with adsorption isotherms.