Introduction The TR-24 is relatively new to the cyclotron market and its advantages over lower energy PET cyclotrons have not yet been fully realized. A new high current [18F] fluoride production target that takes advantage of the higher energy and current afforded by the TR-24 has been developed. Material and Methods The TR-24 cyclotron presents challenges of producing conventional PET isotopes even with its variable energy capability (18–25 MeV). Simultaneous irradiation of two targets that require different proton energies is possible only using beam energy degrader. Due to the relatively wide energy window, the degrader design is not trivial, especially for the high current operation. For example, reduction of beam energy from 24 to 18 MeV would require the use of an approximately 1.5 mm thick aluminum degrader. At 100 μA this degrader would have to be capable of dissipating 700 W of beam power, which would be challenging to achieve with no cooling or using a conventional helium cooling window. However, cooling water used as a beam energy degrader can dissipate several kilowatts of beam energy and provide additional cooling for target material and window foils. FIGURE 1 demonstrates the concept of the water cooled target window. A standard 18F- water target with a 2.5 mL fill volume and a 30 degree beam incident angle was modified to accept the new water window. A 1 mm thick region of circulating cooling water was inserted between the vacuum and the product foil. The combined beam energy degradation caused by the vacuum foil (0.00012“ Havar), the cooling water (1 mm) and the target foil (0.00012“ Havar) was approximately 7 MeV for a 24 MeV incident proton energy. The target was installed on a target selector mounted directly on the TR-24 cyclotron. No additional beam focusing or steering devices were used to defocus or correct beam shape. A small recirculation water system was setup to supply cooling water for the degrader. A mixed bed ion exchange column was installed on the return line to trap N-13 and radioactive metal ions that could possibly be etched from the Havar foils. The water in the degrader was continually circulated in a closed loop providing cooling to the vacuum and target foils. An 800mL/min water flow through the degrader was generated by a low pressure water pump. Results Several tests were performed with O-16 water to establish current – pressure curve and to determine “burn through” current (FIGURE 2). Conclusion Initial tests demonstrated that the new F-18 target with a 1 mm water degrader is capable of accepting power levels in excess of 3.6 kW, operating at 150 μA. More testing is under way, including testing with H218O to determine the F-18 production capacity of this target. We will look into adapting this concept to all ACSI PET targets, including the high current F-18 produc-tion target which can potentially reach an operational current of 200 μA.