This master’s thesis is dealing with analysis of fluid flow pulse in a flexible tube representing e.g. an artery in a human body. In ANSYS program, 3D simulations were performed, and these are so-called interrelated FSI analysis. In Maple software, 1D simulations of fluid flow in the tube were performed for various thin-walled and thick-walled variants. The aim is using these programs to determine the flow rates and pressures in the tube, its wall deformation and stress. Therefore, the theoretical part deals mainly with basic equations of flow dynamics, linear and nonlinear models and rotationally symmetric vessels. In the computational part are described individual procedures in the mentioned programs.