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Zur Durchführbarkeit von spezifischer zytostatischer Therapie bei Patienten mit malignen Erkrankungen in höherem Lebensalter / Retrospektive unizentrische Analyse zur Toxizität und Effektivität einer Hochdosischemotherapie (BEAM) mit autologer Stammzelltransplantation bei Patienten mit rezidiviertem Lymphom im Alter über 60 Jahre / Feasability of cytostatic therapy in elderly patients with malignant diseases / Retrospective single center analysis of toxicity and efficacy in high-dose chemotherapy (BEAM) and autologous stem cell transplantation in elderly patients (> 60 years) with relapsed lymphomaGötz, Nicola Susanne 15 January 2014 (has links)
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A Questionnaire Study to Assess the Value of the Vulnerable Elders Survey, G8, and Predictors of Toxicity as Screening Tools for Frailty and Toxicity in Geriatric Cancer PatientsHentschel, Leopold, Rentsch, Anke, Lenz, Felicitas, Hornemann, Beate, Schmitt, Jochen, Baumann, Michael, Ehninger, Gerhard, Schuler, Markus 22 May 2020 (has links)
Background: The aim of this study was to identify an appropriate screening instrument for the identification of frail elderly patients in a tertiary cancer center. In order to improve cancer care for older patients, the use of a geriatric assessment (GA) has been proposed to identify frail patients or those who are at a higher risk for chemotherapy-related toxicities. In busy clinical routine, an appropriate screening instrument could be used to spare time- and resource-consuming application of GA. Patients and Methods: We administered the Vulnerable Elders Survey (VES-13), G8 questionnaire, and Predictors of Toxicity (POT) as well as a GA at the first visit of 84 consecutive patients at a single Comprehensive Cancer Center. Analysis for patients’ characteristics as well as sensitivity, specificity, and positive and negative predictive value (npv) was conducted. Results: The median age of the patients was 73 years (range 63–93 years), 61.9% were male, most (63%) suffered from gastrointestinal tumors, 39.3% had a multiple cancer diagnosis, and 53.6% had metastasis. 30 (35.7%) individuals were classified as ‘frail’ by the GA. Sensitivity of G8 was 38.3%, and the npv was 63.8%. Sensitivity for VES-13 was 57.1%, and npv was 76.3%. Sensitivity of POT was 72.7%, and the npv was 80.6%. Conclusion: For the first time, the VES13, G8, and POT are compared in a sample of older German patients. The POT seems to be a sufficient screening tool to identify frail patients in a tertiary referral cancer center and helps to save time and resources compared with a complete GA.
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