Human trafficking is a growing illegal crime, both in terms of numbers and profits. Thus, important to consider, as it is a human rights, political, criminal justice, national security, and economic issue. Previous studies have these examined these human trafficking factors independently, yet none have really taken into account how they work simultaneously. This study examines why human trafficker continues to occur, particularly at the domestic and transnational level, and also why some countries are better able to effectively deal with this problem in terms of criminalizing human traffickers. It is argued that at the domestic level, traffickers first must take into account the operating costs, illegal risks, bribery, and profits of the business. After considering these basic elements, they then need to consider the world, including economic, political, geographic, and cultural factors that may help facilitate human trafficking. However, human trafficking can occur across large geographic distances, though rare. This is more likely to happen based on the type of human trafficking group, available expatriate or immigrant networks, the origin-transit-destination country connection, or strength of the bilateral economic relationship between origin and destination countries. Finally, looking at why some countries are better able to criminalize traffickers helps us to better understand how human trafficking can be discouraged. In short, conformity of a country’s domestic anti-human trafficking law, as well as the degree of enforcement, should increase the probability of criminalizing a human trafficker. These three theoretical arguments help to better understand the nature of the business, and more importantly, why human trafficking continues.