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The biological significance of macrocyclic complexes has been recognized since they were first synthesized by Neil Curtis. They have the potential to play a critical role in mimicking metalloprotein active sites. Nine Curtis macrocyclic complexes have been studied using X-ray crystallographic techniques. Their structures have been solved and comparisons of the results have been made. Biological importance is also true of the macrocyclic counterpart; side-off and end-off compartmental ligands. In some circumstances these types of ligands are more appropriate because they have extra flexibility due to their pendant arms not being fixed in place by another head-unit, like a traditional macrocycle. The synthesis of a proposed compartmental ligand; 2,2-(N,Nʼ-bis(benzimidazole-2-ylmethyl)methylamine-5,5ʼ-di-tert-butyl-3,3ʼmethanediyl-dibenzyl alcohol (Ligand 1(L1)), has been proposed and outlined. The pendant arms: bis(benzimidazole-2-ylmethyl)amine (BBIM), were successfully synthesized and characterized with 1H NMR, IR and X-ray crystallography. The head-unit: 5,5ʼ-Di-tert-butyl-2,2ʼ-dihydroxy-3,3ʼ-methanediyl-dibenzene methanol (DHTMBA), of L1 was synthesized and characterized using 1H NMR, IR and mass spectrometry. A similar head-unit; 5,5ʼ-Di-methyl-2,2ʼ-dihydroxy-3,3ʼ-methanediyl-dibenzene methanol (DHMMBA), was synthesized in an effort to shorten the synthetic time of the head-unit. This was consequently converted to the chlorine analogue; 3,3ʼ-Bis(chloromethyl)-5,5ʼ-dimethyl-2,2ʼ-methane-diyldiphenol (Cl-DHMMB), and characterized with 1H NMR, IR and X-ray crystallography. Efforts were made to synthesize Ligand 1, but due to synthetic difficulties and time restraints this proved unsuccessful. Suggestions have been made to develop this synthesis.

Open-ended interview questions were asked to ten college freshmen with learning disabilities (LD) to provide the primary source of data in this qualitative study that was done to explore personal experiences of these students in transitioning from high school to a large university. Student participants were chosen based on meeting the criteria of having a diagnosed specific learning disability, having qualified and received special education services in high school, and at the time of the study were receiving accommodations through the Disability Resource Center (DRC) at the University of Arizona (UA). Students were further identified as members of a "successful" group with a first semester grade point average (GPA) of 3.0 or higher, or members of a "jeopardy" group with a first semester GPA of below 2.0 and the academic status of probation. This was done in order to ensure that I included the perceptions of students at the high and low range of academic status levels in this sample, not to compare or contrast the two groups. Interviews yielded information about student perceptions of barriers, attitudes, resources and assistive factors in the transition process. Data were analyzed to determine themes related to student success and difficulties. Suggestions for further research and information for future practice are offered.

This thesis focuses on secondary instability mechanisms of high-speed boundary layers over cones with a circular cross section. Hypersonic transition investigations at Mach 8 are performed using Direct Numerical Simulations (DNS). At wind-tunnel conditions, these simulations allow for comparison with experimental measurements to verify fundamental stability characteristics.To better understand geometrical influences, flat-plate and cylindrical geometries are studied using after-shock conditions of the conical investigations. This allows for a direct comparison with the results of the sharp cone to evaluate the influence of the spanwise curvature and the cone opening angle. The ratio of the boundary-layer thickness to the spanwise radius is used to determine the importance of spanwise curvature effects. When advancing in the downstream direction the radius increaseslinearly while the boundary-layer thickness stays almost constant. Hence, spanwise curvature effects are strongest close to the nose and decrease in downstream direction. Their influences on the secondary instability mechanisms provide some rudimentary guidance in the design of future high-speed air vehicles.In experiments, blunting of the nose tip of the circular cone results in an increase in critical Reynolds number (c.f. Stetson et al. (1984)). However, once a certain threshold of the nose radius is exceeded, the critical Reynolds number decreases even to lower values than for the sharp cone. So far, conclusive explanations for this behavior could not be derived based on the available experimental data. Therefore, here DNS is used to study the effect of nose bluntness on secondary instability mechanisms in order to shed light on the underlying flow physics. To this end, three different nose tip radii are considered-the sharp cone, a small nose radius and a large nose radius. A small nose radius moves the transition on-set downstream, while for a large nose radius the so-called transition reversal is observed. Experimentalists hold influences of the entropy layer responsible but detailed numerical studies may lead to alternateconclusions.

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