After looking at the existing research and considering the devastating effects of the present COVID-19 pandemic, the problem at the core of this thesis is found in the fact that the world is rather unprepared (Lakoff, 2017) for this type of crisis. While conducting an extensive review of the available resources, the lack of data and attention given to city networks concerning the topic of health was identified. The purpose of this thesis is to fill in the knowledge gap by exploring the potential of transnational city networks as actors in global health governance at times of global health emergencies, such as the present pandemic crisis. I find that the ongoing pandemic presents an opportunity to test the ability of cities and city networks to quickly re-orient their policy focus and collectively mobilize in reaction to a problem that impacts the whole world (Acuto et al., 2021, p.146). As the pandemic evolves, transnational city networks have taken it upon themselves to deal collectively with the public health challenges and economic recovery (Pipa and Bouchet, 2020a, p.606), and in this process, they have without a doubt proven their potential as global health actors, particularly in the initial phase of the pandemic response.