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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
11

Islet tissue autotransplantation - harvesting methods and long-term assessment of graft function

Griffin, S. Michael January 1988 (has links)
No description available.
12

Lung preservation in the rat

Odom, N. J. January 1988 (has links)
No description available.
13

Theoretical structure prediction applied to proteins of the immune system

Bamborough, Paul January 1994 (has links)
No description available.
14

Immunosupression monoclonal antibodies to rat lymphocyte activation antigens

Tellides, George January 1988 (has links)
No description available.
15

Investigation of the mechanism of induction of immunologic unresponsiveness to renal allografts by blood transfusion

Quigley, R. L. January 1988 (has links)
No description available.
16

Studies on the properties and migration of non-lymphoid dendritic cells

Roake, Justin Alan January 1992 (has links)
No description available.
17

Induction of immunologic unresponsiveness by class I MHC antigen : a study in a rat renal allograft model

Foster, Serene January 1989 (has links)
No description available.
18

The role of peptide in direct allorecognition in human transplantation

Pigott, Clive J. January 2002 (has links)
No description available.
19

The significance of antibody production in human renal transplantation

Harmer, Andrea Wendy January 1997 (has links)
Screening for HLA specific antibodies is an important part of laboratory testing for transplantation. The conventional technique for screening is complement dependent lymphocytotoxicity. The development and increasing use of the sensitive flow cytometric crossmatch technique has meant that this conventional screening method is often less sensitive than the final crossmatch. The aim of this study was the development of a flow cytometric screening technique which would be as sensitive as the flow cytometric crossmatch and the investigation of the newly developed ELISA screening method PRA-STAT. These methods were used to investigate antibody production in patients with failed transplants. Flow cytometric analysis of antibody binding to pooled cells was found to be a reliable and sensitive method for the detection of HLA class I and class II specific antibodies. PRA-STAT also detects both class I and class II specific antibodies. Both flow cytometric and PRA-STAT screening methods were shown to be more sensitive than conventional cytotoxic screening. Screening of patients with failed transplants by these sensitive methods showed that the majority of patients produce both HLA class I and class II donor specific antibodies following failure of a primary transplant. Flow cytometric and PRA-STAT screening detected antibody production earlier than cytotoxic screening in some patients. HLA matching was shown to be related to both graft survival and to the levels of antibody produced following graft failure with poorly matched grafts resulting in higher levels of sensitisation than well matched grafts. Patients with detectable post graft failure antibodies had a lower chance of receiving a second transplant and had significantly worse regraft survival than patients with no antibody. The results of the study suggest that HLA class II specific antibodies and repeat class II mismatches may be detrimental in regrafts and this requires further study.
20

Immunological tolerance in the amphibian Xenopus laevis (Daudin)

Farley, Esme Kila January 1987 (has links)
Observation of some of the phenomena of tolerance to soluble protein antigens and allogeneic tissue transplants in Xenopus laevis has formed the framework of the present study. The method of larval induction of high-zone tolerance used in this laboratory has been confirmed and further analysed. Larvae treated with high doses of Human-γ-globulin (HGG) were unable to produce anti-HGG antibody after challenge. The proliferative response demonstrated in the spleens of tolerant toadlets 21 days after challenge was, however, of similar magnitude to that in normally responding animals. Adoptive transfer of high-zone tolerance specific to HGG was demonstrated by intravenous inoculation of tolerant histocompatible splenocytes simultaneously with an antigenic challenge via the dorsal lymph sac. This is indicative of the active involvement of a suppressor T-cell population. The induction of high-zone tolerance in X. laevis results in changes in spleen cell populations as demonstrated by buoyant density gradient separation. Spleen cell sub-populations taken from the separated layers were not, however, effective in the adoptive transfer of tolerance. A normal lymphocyte transfer reaction was observed in X. laevis to show a number of characteristics seen in the mammalian reaction. The use of mitomycin-C treated donor cells and early thymectomized hosts has demonstrated that the phenomenon is composed of donor and host components which are largely distinct from each other. Implantation of allogeneic larval spleens resulted in the induction of transplantation tolerance or impaired rejection in a significant proportion of skin grafted toadlets in which both the donor and host larvae were up to and including stage 51 at the time of transplantation. The implication of these results is that immunomaturity of the donor and host is important in the induction of transplantation tolerance but that other factors must also be involved.

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