Based on the unique clinical correlates of two subtypes of childhood aggression (reactive and proactive), this study examined possible differential treatment effects for children with varying degrees of reactive or proactive aggression receiving one of two types of psychosocial treatment aimed at addressing these unique characteristics. Forty-seven affectively dysregulated children with oppositional defiant disorder (ODD) participated in the study. Results suggest a main effect for type of treatment, modest support for the moderating role of proactive aggression, and no support for reactive aggression as a moderator of treatment outcome. Implications for assessment and treatment of aggression are discussed. / Master of Science

Cognitive behavior theory indicates that situational determinants may have a substantial impact on substance use and relapse into use. The present study described situational use of marijuana in dependent individuals, analyzed relationships among various constructs in existing theory, determined their effects on treatment outcomes, and explored interactions with self-efficacy. Results were generally consistent with hypotheses. Use in negative affective situations was independently associated with psychological distress, maladaptive coping strategies, and poorer outcomes post-treatment. Additionally, negative affective use interacted with self-efficacy for psychologically distressing situations to produce differential outcomes. This study adds to the existing literature on situational marijuana use by establishing relationships with motives for use and lending support to the cognitive behavioral theory model. / Master of Science

Theory and previous research indicate that a person's broader set of life goals may have motivational properties for specific behavior change efforts. The present study examined the types of life goals and ratings of life goal attributes as predictors of marijuana treatment outcomes in a sample of marijuana dependent individuals. Results were generally not consistent with hypotheses. It was expected that ratings of conflict between life goals and marijuana use would be associated with less marijuana use and fewer related problems and dependence symptoms following treatment, but results indicated few associations between life goal ratings and treatment outcome variables. Similarly, types of goals expected to be associated with better treatment outcome were not significantly correlated with reductions in outcome variables at follow-up assessments. Some support was demonstrated for a causal model in which goal conflict with marijuana use influenced posttreatment symptoms of dependence via indirect associations with outcome expectancies and readiness to change. / Master of Science

Examination of the published literature suggests that a substantial number of children are "undermedicated" for the painful conditions they are being evaluated for in the emergency department (ED). The purpose of this retrospective chart review was to examine the differences between the Agency for Health Care Policy and Research (AHCPR) recommendation for acute pain management and actual analgesic administration for children with known painful conditions, fractures, and burns, at one metropolitan level 1 trauma center. A researcher-developed data collection tool was used to examine demographic information, presenting conditions, documented pharmacologic and nonpharmacologic therapies, and documented analgesic administration to children. Results indicated that in all age groups ( n= 100), children received pain medication for known painful conditions (p=.00). Significance was demonstrated that 14-17 year olds are medicated more often compared with 0-4 year olds (p=.01), 5-9 year olds (p=.02) and 10-13 year olds (p=.04). There was no statistical significance in the use of pharmacological interventions for fractures or burns (p=.10). There was no statistical difference in nonpharmacological pain management measures for fractures or burns (p=. 78). Statistical significance was shown (p=.00) for fractures and burns not receiving adequate initial dosages of analgesics per AHCPR guidelines. These findings were consistent with suboptimal analgesic administration for known painful conditions based on AHCPR recommendations.

No description available.

Yes / A 3500‐year‐old papyrus from ancient Egypt provides a list of treatments for many diseases including “bite hair loss,” most likely alopecia areata (AA). The treatment of AA remained largely unchanged for over 1500 years. In 30 CE, Celsus described AA presenting as scalp alopecia in spots or the “windings of a snake” and suggested treatment with caustic compounds and scarification. The first “modern” description of AA came in 1813, though treatment still largely employed caustic agents. From the mid‐19th century onwards, various hypotheses of AA development were put forward including infectious microbes (1843), nerve defects (1858), physical trauma and psychological stress (1881), focal inflammation (1891), diseased teeth (1902), toxins (1912) and endocrine disorders (1913). The 1950s brought new treatment developments with the first use of corticosteroid compounds (1952), and the first suggestion that AA was an autoimmune disease (1958). Research progressively shifted towards identifying hair follicle‐specific autoantibodies (1995). The potential role of lymphocytes in AA was made implicit with immunohistological studies (1980s). However, studies confirming their functional role were not published until the development of rodent models (1990s). Genetic studies, particularly genome‐wide association studies, have now come to the forefront and open up a new era of AA investigation (2000s). Today, AA research is actively focused on genetics, the microbiome, dietary modulators, the role of atopy, immune cell types in AA pathogenesis, primary antigenic targets, mechanisms by which immune cells influence hair growth, and of course the development of new treatments based on these discoveries. / Alopecia UK.

Adult marijuana users seeking treatment (N = 291) were randomly assigned to 3 treatment conditions: 1) a cognitive-behavioral relapse prevention support group (RPSG), 2) individualized assessment and advice group, and 3) delayed treatment control group. The purpose of this study was to investigate the role of self-efficacy in goal setting and treatment outcomes based on self-stated goals (abstinence or moderation) for marijuana use. Measures of marijuana use, treatment goal, and self-efficacy for achieving one's goal were used. Goal choice was shown to influence treatment outcome such that, participants were more likely to achieve outcomes consistent with their treatment goal. The findings suggest that self-efficacy for goal achievement is more strongly related to outcomes for those with abstinence treatment goals, but appears to exert some effect across both goal types. / Master of Science

Substance use disorders (SUDs) are often comorbid with other psychopathology such as mood disorders, anxiety disorders, and personality disorders. While some research suggests individuals with comorbid psychopathology are more likely to seek substance use treatment than those with independent disorders, other studies have also shown many individuals with dual diagnoses still never seek treatment. Moreover, few studies have tried to elucidate the underlying structure of SUD treatment rejection, and instead examined it in more simplistic terms. In addition, studies have tended to examine the impact of individual disorders on treatment rejection, but have not incorporated an empirically supported approach to conceptualizing psychopathology in terms of comorbidity between broad latent dimensions referred to as internalizing (e.g., depression, anxiety) and externalizing (e.g., antisocial personality disorder, polysubstance use) psychopathology. Modeling psychopathology in terms of internalizing and externalizing psychopathology is becoming a prominent approach to understanding mental disorders, yet little research to date has investigated the effects these broad dimensions have on SUD treatment rejection. The current study utilized latent variable modeling techniques to (1) determine the latent structure of SUD treatment rejection in a large U.S. sample, and investigate whether treatment rejection is a multidimensional construct; and (2), to explore the ability of internalizing psychopathology, externalizing psychopathology, and personality pathology to predict the SUD treatment rejection factor(s). The current study relied on use of a general population sample of 43,093 individuals from the first wave of National Institute on Alcohol Abuse and Alcoholism's National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) study. Support was found for the hypothesis that SUD treatment rejection would be a multidimensional construct.  Exploratory structural equation modeling indicated a three-factor model best fit the data. Operational definitions and clinical implications of these three treatment rejection factors ("Objective barriers," "Psychological barriers," and "Self-focused barriers") are discussed. Among internalizing psychopathology, externalizing psychopathology, and personality pathology, structural equation modeling identified internalizing psychopathology as the most robust predictor of these three factors for alcohol treatment rejection (n = 1063), indicating endorsement of treatment barriers increased as levels of internalizing psychopathology increased. This pattern also held true for externalizing psychopathology, while personality pathology only negatively predicted objective treatment barriers.  For drug treatment rejection (n = 562), only internalizing psychopathology significantly predicted the treatment rejection factors, indicating treatment endorsement of drug treatment barriers increased as levels of internalizing psychopathology increased. Implications of these findings and directions for future research are discussed.

A research report submitted to the Faculty of Engineering and the Built Environment, University of the Witwatersrand, Johannesburg, in partial fulfilment of the requirements for the degree of Masters of Science in Engineering. University of the Witwatersrand, Johannesburg, 2016 / With the current tough economic times and depressed commodity prices, focus is being placed on achieving higher power densities in gears without increased cost or reduced achievable life and reliability. An investigation into the use of different carburisation methods and processes to minimise post heat treatment distortion, with the aim to reduce and even eliminate the requirement for post heat treatment grinding and grinding stock allowances is presented. The investigation included the processing of test pieces, as per the recommendations of AGMA 2004-B89: Gear Materials, Heat Treatment and Processing Manual. Four alloy steels, namely AISI 3310, AISI 8620, AISI 9310 and 17CrNiMo6, were selected for this research, based on availability, cost and hardenability. The carburising cycles were derived for both gas and vacuum carburising for a 0.10% and 0.20% carbon steel respectively. Two quenching options were applied, oil quenching and intensive quenching. The test pieces were 3-dimensionally measured to determine distortion through the changes in diameter and ovality. The microstructures of the case and core were analysed, as well as effective case depth. This research found that current methods, atmospheric carburising and oil quenching, and steel alloy combinations are inadequate to produce low distortion carburised internal gears, while the use of vacuum carburising and intensive quenching as a process combination can achieve such gears. It was also found that the use of AISI 3310, performed the best for both current and proposed process combinations. It is recommended that future work be conducted, including a full-scaled manufacturing trial with more detailed process adjustments to ensure the quality and repeatability of the final carburised gear. / MT2017

A dissertation submitted to the Faculty of Engineering and the Built Environment, University of the Witwatersrand, Johannesburg, in fulfilment of the requirements for the degree of Master of Science in Engineering. Johannesburg 2016 / Horizontal subsurface flow constructed wetlands (HSSF CWs) are being considered in South Africa as an alternative waste water treatment technology which is low in capital costs and typically requires less operational infrastructure when compared to conventional treatment technologies. HSSF CWs may thus be a potential solution for solving the challenge of ensuring reliable access to clean water for rural communities whose municipalities may not be able to afford the construction of a waste water treatment plant as well as not being able to supply sufficient technical expertise for the operation thereof. Proper design of HSSF CWs requires a detailed investigation into the hydraulic behaviour as it has a direct effect on the treatment performance in these systems. In this study, three available hydraulic modelling methodologies for HSSF CWs were compared and these are the impulse, step change integral and step change derivative modelling methodologies. Hydraulic data were generated from planted and unplanted pilot scale HSSF CWs using residence time distribution (RTD) studies and the modelling results using each methodology were compared. It was found that each methodology was capable of suggesting a different hydraulic behaviour for the same system being studied and since it is not possible to evaluate an analytical answer to the problem independently it was not possible to determine which modelling methodology was the most accurate. Practical limitations of the experiments used to feed hydraulic data to the respective methodologies were also highlighted. Despite a well-designed sampling regime it was not possible to capture sufficient data surrounding the peak of the impulse response curve and may have impacted negatively on the modelling results. No such difficulties were encountered with the step change tracer experiments. The mathematical techniques which each methodology employs were also critically assessed. It was found that numerical differentiation in the step change derivative modelling approach introduced noise into the RTD curve and may have affected subsequent results. Ultimately each methodology has its own associated strengths and weaknesses and choice of methodology may be dictated by other factors such as cost to set up the hydraulic experiment as well as equipment availability. Tasks two and three of this dissertation dealt with how Biomimicry can be used as a tool to develop more sustainable HSSF CW designs and hydraulic modelling processes. In task two, hydraulic data generated from the first task were used to develop estimates of the velocity profiles inside a planted HSSF CW to identify regions most prone to clogging, a phenomenon which would be a serious concern for rural communities whose sole water treatment system would be the CW. Biomimetic design principles were combined with the modelling results to develop a modular system design allowing for sections of the CW to be removed for cleaning while still allowing for continuous treatment of the waste water. Task three explored the use of heat as a hydraulic tracer. Heat is considered more environmentally friendly when compared to chemicals as tracers as the CW can equilibrate to ambient conditions post study and the effluent does not require dedicated disposal infrastructure. Heat is non-conservative in these systems and processes such as absorption by the subsurface media and loss to the surroundings distort the hydraulic response curve from which the hydraulic behaviour cannot be directly obtained. In this study a mathematical model was developed which maps a heat tracer response curve to one which would be obtained if a conservative chemical tracer were used. It was tested by conducting a combined heat-chemical tracer study on an unplanted laboratory-scale HSSF CW and the predicted chemical response curve was compared with the actual experimental response curve. The model performed satisfactorily indicated by a 5% and 6% relative difference in the Peclet number (Pe) and mean of the RTD respectively. In each of these chapters, an abstract is provided which summarizes the main findings of the study. / MT2017