More than hundred years after the discovery of X-rays different kinds of ionizing radiation are ubiquitous in medicine, applied to clinical diagnostics and cancer treatment as well. Irrespective of their nature, the widespread application of radiation implies its precise dosimetric characterization and detailed knowledge of the radiobiological effects induced in cancerous and normal tissue. Starting with in vitro cell irradiation experiments, which define basic parameters for the subsequent tissue and animal studies, the whole multi-stage process is completed by clinical trials that translate the results of fundamental research into clinical application. In this context, the present dissertation focuses on the establishment of radiobiological in vitro cell experiments at unconventional, but clinical relevant radiation qualities. In the first part of the present work the energy dependent biological effectiveness of photons was studied examining low-energy X-rays (≤ 50 keV), as used for mammography, and high-energy photons (≥ 20 MeV) as proposed for future radiotherapy. Cell irradiation experiments have been performed at conventional X-ray tubes providing low-energy photons and 200 kV reference radiation as well. In parallel, unconventional quasi-monochromatic channeling X-rays and high-energy bremsstrahlung available at the radiation source ELBE of the Forschungszentrum Dresden-Rossendorf were considered for radiobiological experimentation. For their precise dosimetric characterization dosimeters based on the thermally stimulated emission of exoelectrons and on radiochromic films were evaluated, whereas just the latter was found to be suitable for the determination of absolute doses and spatial dose distributions at cell position. Standard ionization chambers were deployed for the online control of cell irradiation experiments. Radiobiological effects were analyzed in human mammary epithelial cells on different subcellular levels revealing an increasing amount of damage for decreasing photon energy. For this reason, the assumed photon energy dependence was reconfirmed for a cell line other than human lymphocytes, an important finding that was discussed on the 2007 Retreat of the German Commission on Radiological Protection. After successful finalization of the photon experiments the focus of the present dissertation was directed to the realization of in vitro cell irradiation experiments with laser-accelerated electrons. This research was carried out in the frame of the project onCOOPtics that aims on the development of laser-based particle accelerators, which promise accelerators of potentially compact size and more cost-effectiveness suitable for a widespread medical application, especially for high precision hadron therapy. The unique properties, i.e., the ultrashort bunch length and resultant ultrahigh pulse dose rate, of these unconventional particle accelerators demand for extensive investigations with respect to potential effects on the dosimetric and radiobiological characterization. Based on the experiences gained at ELBE first experiments on the radiobiological characterization of laser-accelerated electrons have been performed at the Jena Titanium:Sapphire laser system. After beam optimization, a sophisticated dosimetry system was established that allow for the online control of the beam parameters and for the controlled delivery of dose to the cell sample. Finally, worldwide first systematic in vitro cell irradiation experiments were carried out resulting in a reduced biological effectiveness for laser-accelerated electrons relative to the 200 kV X-ray reference, irrespectively on the biological effect and cell lines examined. These successful results are the basis for future in vivo studies and experiments with laser-accelerated protons.

Thesis (M.S.)--Rutgers University, 2009. / "Graduate Program in Mechanical and Aerospace Engineering." Includes bibliographical references (p. 105-106).

Thesis (Ph. D.)--Rutgers University, 2009. / "Graduate Program in Mechanical and Aerospace Engineering." Includes bibliographical references (p. 111-115).

Thesis (Ph. D.)--Hong Kong University of Science and Technology, 2002. / Includes bibliographical references (leaves 155-160). Also available in electronic version. Access restricted to campus users.

Thesis (Ph. D.)--Hong Kong University of Science and Technology, 2002. / Includes bibliographical references (leaves 145-150). Also available in electronic version. Access restricted to campus users.

The aim of this thesis is to establish the extent to which materials can be deformed under shear-dominant loadings. Custom Al-6061-T6 tubular specimens are loaded under radial and corner paths of tension and shear to failure. During the experiments, the deformation is monitored in a test section designed to have nearly uniform stress and deformation at large strains while providing minimum constraint to the development of localization that precedes failure. The recorded shear stress-rotation and axial stress-displacement responses exhibit maxima beyond which deformation localizes in a narrow band that is of the order of the 1 mm wall thickness of the test section. For the mainly shear dominated stress paths followed, deformation remained nearly planar allowing for the establishment of both the true stresses and the local deformation strictly from measurements. Results from thirteen radial path experiments as well as from four corner path experiments show the strain at failure to monotonically increase as the mean stress decreases, a result that is in contrast with previously reported results for Al alloys. Also, the measured failure strains are significantly larger than previously reported values. Analysis of corner stress paths investigates the path dependence of localization and failure. Results show little path dependence on the failure strains, but some path dependence on stress maxima and failure stresses. Furthermore, statistical grain-level strain estimates from five of the stress paths revealed a significant variation in strain across the macroscopically observed localization zone. In the neighborhood of the crack tip strains with 25-100% higher levels than the macroscopic values were recorded. This indicates that localization also occurs at a smaller scale than hitherto understood. The difference between the macro strain at failure and the average grain level values increased as the axial/shear stress ratio increased. / text

published_or_final_version / Obstetrics and Gynaecology / Doctoral / Doctor of Philosophy

A new wall construction technique utilizing concrete filled PVC tubes, adobe, polyethylene terephthalate (PET) plastic bottles and cabling was designed, analyzed and implemented. The system was designed as an alternative to traditional earthen buildings in Honduras that are vulnerable to hurricane winds and seismic activity. Six prototype panels were constructed at the Alternative Village located at the University of Manitoba to evaluate the wall system for racking and transverse load capacity. A kitchen was then constructed at an elementary school in western Honduras. / October 2015

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