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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
Search results
Showing 1 to 10 of 25 (0.022 seconds)| 1 |
The influence of microvascular pericytes on endothelial cell characteristics and gene expressionMcIlroy, Marie January 2003 (has links)
No description available.
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A novel human stress response gene with a potential role in induced radioprotection and cell cycle controlMcKeen, Hayley January 2003 (has links)
No description available.
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A study of angiogenesis and the pharmacological reactivity of blood vessels in granulation tissue and tumours in miceAndrade, Silvia Passos January 1993 (has links)
No description available.
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Heterogeneity in human gliomas : in vitro and in vivo studies of astrocytic neoplasiaFranks, Antony John January 1989 (has links)
No description available.
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A quantitative study of hyperthermia in human tumoursTait, Diana Mary January 1988 (has links)
No description available.
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Regulation of MMP-9 in human ovarian cancerLeber, Thomas Matthias January 1998 (has links)
No description available.
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Studies on angiogenesis in head and neck squamous cell carcinomaHomer, Jarrod James January 2000 (has links)
No description available.
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Tissue transglutaminase : a new secretory proteinGaudrey, Claire Anne January 1998 (has links)
No description available.
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The synthesis of indole containing anticancer compoundsRoffey, Jonathan R. A. January 1996 (has links)
The concept of bioreductive prodrug chemotherapy is introduced in chapter 1. Tumour cell hypoxia is a significant factor in limiting tumour growth control with conventional radiotherapy and some chemotherapeutic agents. Following therapy these cells can repopulate and cause a relapse of the cancer. On the other hand, hypoxia is unique to tumours, and is therefore potentially exploitable. Bioreductive prodrugs are compounds in which a oxygen inhibited redox-based bioactivation step triggers a reaction leading to a lethal intermediate. The concept of bioreductive DNA alkylators and DNA topoisomerase 11 inhibitors is discussed. The synthesis of model thiazolylindole compounds based on the natural product BE \0988 are discussed in chapter 2. Two strategies were employed for the construction of the thiazolylindoles: the Hantzsch reaction; and nucleophilic substitution on 2-bromothiazole by an indolyl anion. The synthesis of thiazolylindolequinone compounds are discussed in chapter 3. The quinone C(5) position of the thiazolylindolequinone analogues was elaborated to provide a series of cyclic and acyclic C(5)-amino derivatives. Synthetic strategies towards the synthesis of indole-2-carboxylates are discussed in chapter 4. The Moody-Rees and Cadogan-Sundberg reactions were employed to provide a synthesis of the useful highly substituted indole [154]. The Brederek imidazole reaction (i.e., the reaction of a amidine and a-halo ketone) is discussed in chapter 5. Application of the Brederek reaction was employed towards the construction of the bisindole imidazole natural compounds, the nortopsentins. The biological properties of the compounds of the compounds synthesised are discussed in chapter 6. The compounds were tested for DNA topoisomerase 11 inhibitory activity and cytotoxicity under a hypoxic environment.
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Regulation of cell proliferation and apoptosis in pancreatic cancerEvans, James Donald January 1998 (has links)
No description available.
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