- About
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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
Search results
Showing 11 to 20 of 85 (0.037 seconds)| 11 |
The role played by BRCA1 in mediating the cytotoxic effect of antimicrotubule agentsMcKenna, Sarah Mary Michelle January 2002 (has links)
No description available.
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| 12 |
Investigation of protein-protein interactions involving Retinoblastoma Binding Protein 6 using immunoprecipitation and Nuclear Magnetic Resonance SpectroscopyChen, Po-An January 2019 (has links)
>Magister Scientiae - MSc / Retinoblastoma Binding Protein 6 (RBBP6) is a 200 KDa multi-domain protein that has been
shown to play a role in mRNA processing, cell cycle arrest and apoptosis. RBBP6 interacts with
tumour suppressor proteins such as p53 and pRb and has been shown cooperate with Murine
Double Minute 2 (MDM2) protein in catalyzing ubiquitination and suppression of p53.
Unpublished data from our laboratory has suggested that RBBP6 and MDM2 interact with each
other through their RING finger domains. RBBP6 has also been shown to have its own E3 ubiquitin
ligase activity, catalyzing ubiquitination of Y-Box Binding Protein 1 (YB-1) in vitro and in vivo. YB-
1 is a multifunctional oncogenic protein that is generally associated with poor prognosis in cancer,
tumourigenesis, metastasis and chemotherapeutic resistance. Unpublished data from our
laboratory shows that RBBP6 catalyzes poly-ubiquitination of YB-1, using Ubiquitin-conjugating
enzyme H1 (UbcH1) as E2 ubiquitin conjugating enzyme. We have furthermore shown that the
zinc knuckle of RBBP6 interacts specifically with the Ubiquitin-associated domain (UBA) domain
of UbcH1.
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| 13 |
Localization of a novel t(1;7) translocation associated with Wilms' tumourReynolds, Paul Andrew January 1997 (has links)
No description available.
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| 14 |
An investigation of antiproliferative genes on human chromosome 9England, Nicole Lesley January 1996 (has links)
No description available.
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| 15 |
The role of p53 in cell transformation by BPV-4Scobie, Linda January 1996 (has links)
No description available.
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| 16 |
Regulation of E2F activity by p14'A'R'FMason, Sarah Louise January 2001 (has links)
No description available.
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| 17 |
Analysis of human p53 function in fission yeast : a no-hybrids approachWaddell, Scott January 1996 (has links)
No description available.
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| 18 |
Expression of oestrogen receptor-#alpha# in human cancer cell linesO'Doherty, Aideen Maire January 1999 (has links)
No description available.
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| 19 |
An investigation into loss of cell-cycle control in oesophageal carcinomaMorgan, R. J. January 1998 (has links)
No description available.
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| 20 |
An investigation of genetic alterations in gastric and colorectal cancerSud, Richa January 1998 (has links)
No description available.
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