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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 81 to 90 of 304 (0.036 seconds)Spelling suggestions: "subject:"tumour.""
| 81 |
The metabolism and mutagenicity of the mushroom hydrazine, agaritineWalton, Kim January 1998 (has links)
No description available.
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| 82 |
Mathematical oncology and periodic wave train forcingWebb, Steven D. January 2000 (has links)
No description available.
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| 83 |
A new glioma-associated cell surface glycoproteinMulligan, Karl Andrew January 1997 (has links)
No description available.
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| 84 |
The contribution of B-loop residues of epidermal growth factor to receptor binding and activationAndrews, A. L. January 2001 (has links)
No description available.
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| 85 |
Processing-independent analyses of chromogranin AHogg, Robert Bernard January 1998 (has links)
No description available.
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| 86 |
Regulated antagonism of immune suppressive molecules in tumoursAlamoudi, Aliaa January 2014 (has links)
Despite expressing antigens that can induce immune surveillance and immune eradication, tumours demonstrate the capacity to evade anti-tumour immunity. Recently, this has been attributed to the ability of tumours to induce a local immunosuppressed micro-environment, which is a major obstacle to successful natural and vaccine induced anti-tumour immunity. Soluble factors such as transforming growth factor beta (TGFβ), and interleukin 10 (IL-10), released by cancer and stromal cells, are thought to play a significant role in this local immunosuppression. In order to assess the influence of antagonising these soluble factors locally on tumour biology and tumour immunity, a murine CT26 colorectal carcinoma model that can express cytokine antagonists under Doxycycline (Dox) control was engineered. Two stable CT26 cell lines expressing Dox-inducible soluble extracellular domain of TGFβ receptor II (STGFβRII) or soluble extracellular domain of IL-10 receptor (SIL-10R), were established. Expression of STGFβRII in vitro and in vivo was only evident after Dox treatment. When Dox was administered directly following subcutaneous (s.c.) inoculation of STGFβRII-expressing CT26 cells into Balb/c mice, tumour growth was significantly suppressed. Interestingly, inducing STGFβRII in well-established tumours showed less suppression of tumour growth. To assess the effect of expressing STGFβRII on tumour immunity the RNA expression of 22 common cytokines was measured in the tumours of mice receiving Dox and control mice. The levels of some of these cytokines were modulated by STGFβRII expression (e.g TGFβ,Tnfsf9, IL-2). We also tested for any additive effect between expressing STGFβRII, and the administration of anti-CTLA-4 antibody on tumour growth, and tumour immunity. The model described here could help address various limitations seen previously in studies of TGFβ blockade. It provides means of effective local antagonism, and it addresses immunological endpoints which have been limited in previous studies. Because of its tight regulation, the model also allows identification of the best timing of TGFβ blockade alone or in combination with other immunotherapeutics.
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| 87 |
99mTc labelling of interleukin-2 for in-vivo detection of lymphocytic infiltrationChinaelli, Marco January 1996 (has links)
No description available.
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| 88 |
The contribution of cyclooxygenase-1 and -2 in murine colorectal adenocarcinoma growthBrown, Joanne Rosalie January 2001 (has links)
No description available.
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| 89 |
Glycoprotein hormone expression in the anterior pituitaryAylwin, Simon John Byng January 2001 (has links)
No description available.
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| 90 |
Staging of lung cancer by magnetic resonance imagingAl-Ghamdi, Ahmad Hamoud January 1997 (has links)
No description available.
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