Embedded systems are becoming ubiquitous in our daily life. Due to close interaction with physical world, embedded systems are typically subject to timing constraints. At design time, it must be ensured that the run-time behaviors of such systems satisfy the pre-specified timing constraints under any circumstance. In this thesis, we develop techniques to address the timing analysis problems brought by the increasing complexity of underlying hardware and software on different levels of abstraction in embedded systems design. On the program level, we develop quantitative analysis techniques to predict the cache hit/miss behaviors for tight WCET estimation, and study two commonly used replacement policies, MRU and FIFO, which cannot be analyzed adequately using the state-of-the-art qualitative cache analysis method. Our quantitative approach greatly improves the precision of WCET estimation and discloses interesting predictability properties of these replacement policies, which are concealed in the qualitative analysis framework. On the component level, we address the challenges raised by multi-core computing. Several fundamental problems in multiprocessor scheduling are investigated. In global scheduling, we propose an analysis method to rule out a great part of impossible system behaviors for better analysis precision, and establish conditions to guarantee the bounded responsiveness of computing tasks. In partitioned scheduling, we close a long standing open problem to generalize the famous Liu and Layland's utilization bound in uniprocessor real-time scheduling to multiprocessor systems. We also propose to use cache partitioning for multi-core systems to avoid contentions on shared caches, and solve the underlying schedulability analysis problem. On the system level, we present techniques to improve the Real-Time Calculus (RTC) analysis framework in both efficiency and precision. First, we have developed Finitary Real-Time Calculus to solve the scalability problem of the original RTC due to period explosion. The key idea is to only maintain and operate on a limited prefix of each curve that is relevant to the final results during the whole analysis procedure. We further improve the analysis precision of EDF components in RTC, by precisely bounding the response time of each computation request.