Graduation date: 1992

Heart failure is a chronic condition that increases the risk for death and disability. Beta blockers and ACE inhibitors have become standard treatments in heart failure because clinical trials have demonstrated their beneficial effect on mortality and morbidity in these patients. As not much is known about adherence to these medications, the main objectives of this project were to determine long term adherence to ACE inhibitors and beta blockers and determine how various degrees of adherence to a beta blocker can affect major health outcomes in patients with heart failure.<p> Data was obtained from Saskatchewan health from January 1, 1994 to December 31, 2003 for all heart failure patients from their first hospitalization for heart failure. Adherence was calculated using the fill frequency measure of adherence, and all survival analyses were completed using the Cox proportional hazards model.<p>Although 14, 000 patients were admitted to hospital for a first admission for heart failure, only 1143 subjects started a beta blocker and 5084 subjects started an ACE inhibitor within 3 months of the index hospitalization. Within the first year, adherence was excellent for both beta blockers (80.8 percent) and ACE inhibitors (82.5 percent). The proportion of patients remaining adherent slowly decreased to reach approximately 60 percent, for both medication classes, after 4 years. There was no significant difference in all-cause mortality between patients with high adherence and low adherence, but there appeared to be a trend towards decreased survival time in those remaining adherent throughout the study period [HR = 1.18 (95% CI: 0.98 to 1.43; p=0.07)].<p>Since the overall rate of adherence to beta blockers was excellent in most patients during the first year, it is possible that non-adherence is not responsible for a significant burden of mortality in Saskatchewan heart failure patients, and perhaps and the focus of quality improvement should be optimal prescribing of evidence-based therapies, and continued adherence over time.

Due to increasing shortage of wood supply and higher environmental concerns with the depletion of forest resources, in recent years, there is a strong interest in using forest and agricultural residues for development of value added products. Bark is a mill-waste residue, available in plenty, having limited uses and causing disposal problems. Bark possesses a large amount of phenolic compounds, which can act as an adhesive in making panels, however only limited research has been done in this area. The main objective of this project is to develop bark-based environment-friendly panels with and without synthetic resins, using mountain pine beetle infested lodgepole pine barks. Analysis of bark constituents, barkboard development, mechanical properties evaluation, characterization and improvement tests were performed. Various results support the possibility of bark utilization for barkboards production; however, more research is required for further improvements and feasible commercial production process.

Due to increasing shortage of wood supply and higher environmental concerns with the depletion of forest resources, in recent years, there is a strong interest in using forest and agricultural residues for development of value added products. Bark is a mill-waste residue, available in plenty, having limited uses and causing disposal problems. Bark possesses a large amount of phenolic compounds, which can act as an adhesive in making panels, however only limited research has been done in this area. The main objective of this project is to develop bark-based environment-friendly panels with and without synthetic resins, using mountain pine beetle infested lodgepole pine barks. Analysis of bark constituents, barkboard development, mechanical properties evaluation, characterization and improvement tests were performed. Various results support the possibility of bark utilization for barkboards production; however, more research is required for further improvements and feasible commercial production process.

Three experiments were conducted (1) to develop and characterize polyclonal antibodies against ovine adipocyte plasma membranes (APM), (2) to evaluate the effect of administering the developed antibodies to lambs on lamb growth and carcass characteristics, and (3) to investigate the possibility of using the developed antibodies to identify antigenic components on ovine APM that are tissue, species and possibly site specific. In Experiment 1, the developed antibodies showed a high rate of reactivity to APM and cross reacted with plasma membranes (PM) from liver, kidney, heart and erythrocytes. Adsorption of antisera with either liver PM or erythrocyte PM for 6 h resulted in a significant reduction in antisera cross-reactivity to liver or erythrocyte PM, respectively, with little effect on its specific reactivity to APM or cross-reactivity with PM of the other tissues tested. The antisera also reacted in different affinities to APM from sheep, pig and rat. The antisera also showed differential binding to APM isolated from different anatomical locations. In Experiment 2, five wether lambs were assigned to either a control or treatment group to study the effect of passive immunization with the antisera immunoglobulin (ASig) on lamb growth and carcass characteristics. Treatment with ASig resulted in a significant (P<.OS) reduction of 45% in wet perirenal fat weight, and of 1.8 and 0.8% in subcutaneous and perirenal lipid content, respectively. ASig immunization also significantly (P<.O5) reduced blood plasma non-esterified fatty acid without adversely affecting blood plasma triglycerides or packed cell volumes (hematocrit). Animals immunized with ASig also showed a significant (P<.OS) reduction in average weight daily weight gain, but this effect was not associated with any adverse effect on efficiency of carcass production. Moreover, passive immunization tended to improve protein accretion and efficiency of nitrogen utilization. In Experiment 3, the developed antisera immunoglobulins recognized three unique ovine APM components, in comparison with plazma membranes from liver, kidney, heart or RBC, with molecular weights of 70, 106 and 110 KD, and showed to react more intensely with APM antigenic components that are in common with PM of the tissues tested. Antisera immunoglobulins recognized just two (44, 46 KD) antigenic components on porcine APM that are shared with those of ovine APM but did not react with any component on APM of either rat or chicken. / Graduation date: 1990

This master’s thesis has been written within the field of Electrical Engineering at the Department of Science and Technology, Linköping University. The work has been carried out at Ericsson’s site in Linköping during the spring of 2010. The purpose of this master thesis was to construct a model which could capture and present the utilization rate of test equipment at a telecom company in general. Since this field has not been studied very much in the past, it was decided to study a model from the production industry and try to reuse some of the basic ideas from this model. From this generic model a recommendation is given as to how the model could be used by implementing a Common Utilization Tool, which could be used to store, configure and present utilization data from all types of equipment in Ericsson’s test environment. This common utilization tool will use measurement modules that will both collect and classify the state of the equipment and deliver the result to a common database. To this Common Utilization Tool a measurement module has been implemented which samples Base Station Controllers (BSC) in Ericsson’s test environment state; used, unused and down. This implementation is also validated against real measured data from testers to conclude if the results are accurate.

Heart failure is a chronic condition that increases the risk for death and disability. Beta blockers and ACE inhibitors have become standard treatments in heart failure because clinical trials have demonstrated their beneficial effect on mortality and morbidity in these patients. As not much is known about adherence to these medications, the main objectives of this project were to determine long term adherence to ACE inhibitors and beta blockers and determine how various degrees of adherence to a beta blocker can affect major health outcomes in patients with heart failure.<p> Data was obtained from Saskatchewan health from January 1, 1994 to December 31, 2003 for all heart failure patients from their first hospitalization for heart failure. Adherence was calculated using the fill frequency measure of adherence, and all survival analyses were completed using the Cox proportional hazards model.<p>Although 14, 000 patients were admitted to hospital for a first admission for heart failure, only 1143 subjects started a beta blocker and 5084 subjects started an ACE inhibitor within 3 months of the index hospitalization. Within the first year, adherence was excellent for both beta blockers (80.8 percent) and ACE inhibitors (82.5 percent). The proportion of patients remaining adherent slowly decreased to reach approximately 60 percent, for both medication classes, after 4 years. There was no significant difference in all-cause mortality between patients with high adherence and low adherence, but there appeared to be a trend towards decreased survival time in those remaining adherent throughout the study period [HR = 1.18 (95% CI: 0.98 to 1.43; p=0.07)].<p>Since the overall rate of adherence to beta blockers was excellent in most patients during the first year, it is possible that non-adherence is not responsible for a significant burden of mortality in Saskatchewan heart failure patients, and perhaps and the focus of quality improvement should be optimal prescribing of evidence-based therapies, and continued adherence over time.

In this study, two different flow field plates, a serpentine field plate and a perforated filed plate, were produced by LIGA-like formation and micro electroforming technology. The two type field plates were also used to make up three different types of micro proton exchange membrane fuel cells (&#x00B5;PEMFCs), serpentine (anode)-serpentine (cathode), serpentine-perforated, and perforated-perforated, each of whose active area is 1 cm2. In addition to the performance tests under different flow rate, operation temperature, and relative humidity conditions, electrochemical impedance spectroscopy (EIS) and cyclic votammetry (CV) methods were also adapted to measure correspondent EIS and Pt utilization of MEA. Even the fuel cell with serpentine field plates in anode and cathode needs more pressure input, the extra pressure is effective to avoid the water accumulation and to raise the total performance.

Many real-time systems demand effective and efficient delay-guaranteed services to meet timing requirements of their applications. We note that a system provides a delay-guaranteed service if the system can ensure that each task will meet its predefined end-to-end deadline. Admission control plays a critical role in providing delayguaranteed services. The major function of admission control is to determine admissibility of a new task. A new task will be admitted into the system if the deadline of all existing tasks and the new task can be met. Admission control has to be efficient and efficient, meaning that a decision should be made quickly while admitting the maximum number of tasks. In this dissertation, we study a utilization-based admission control mechanism. Utilization-based admission control makes an admission decision based on a simple resource utilization test: A task will be admitted if the resource utilization is lower than a pre-derived safe resource utilization bound. The challenge of obtaining a safe resource utilization bound is how to perform delay analysis offline, which is the main focus of this dissertation. For this, we develop utilization-based delay guarantee techniques to render utilization-based admission control both efficient and effective, which is further confirmed with our data. We develop techniques for several systems that are of practical importance. We first consider wired networks with the Differentiated Services model, which is wellknown as its supporting scalable services in computer networks. We consider both cases of providing deterministic and statistical delay-guaranteed services in wired networks with the Differentiated Services model. We will then extend our work to wireless networks, which have become popular for both civilian and mission critical applications. The variable service capacity of a wireless link presents more of a challenge in providing delay-guaranteed services in wireless networks. Finally, we study ways to provide delayguaranteed services in component-based systems, which now serve as an important platform for developing a new generation of computer software. We show that with our utilization-based delay guarantee technique, component-based systems can provide efficient and effective delay-guaranteed services while maintaining such advantages as the reusability of components.

Two experiments were undertaken to assess the dietary effects of microbial phytase on growth performance, mineral utilization, and immune responses in groupers, Epinephelus coioides. Basal diet contained fish meal and soybean meal as protein source and no phosphorus supplement. In experiment I, test diets containing 0 (0.2% sodium phosphate was supplemented; 0+P), 200, 400, 600, 800 FTU phytase/ kg were assigned to triplicate tanks and were fed for 12wk. Fish fed diet containing 0+P or 400 FTU phytase/kg showed better weight gains. Supplementation of phytase had no effect on feed efficiency, body tissue proximate composition, vertebral ash, and vertebra and whole-body phosphorus concentrations. Phosphorus utilization was improved and excretion tended to reduce for fish fed diets containing 400 and 600 FTU phytase/kg than the other treatments. Experiment II evaluated the effects of phytase supplementation on utilization of phosphorus, zinc and iron, and relative immune responses of the groupers. Three diets were formulated base on the results of experiment 1 to contain 0, 0+P or 400 FTU phytase/kg. The results of the 8-wk feeding trial indicated that phosphorus, zinc and iron utilizations were higher for fish fed diet containing inorganic phosphorus (0+P) than the phytase-containing diet. Phytase supplementation did not significantly affect immune responses. The present results indicated that phytase at the dosage of 400 FTU/kg is a suitable level in grouper diets, which would increase utilization and lessen excretion of dietary phosphorus.