Recently, the coverage rating of child vaccination services in developing countries, like Uganda, is lower than developed countries. The low resource setting is the reason that causes the poor vaccination performance. Health workers suffer from the heavy workload, low budget supplement and bad traffic condition, etc. Which constrains the quality of vaccination services. In this thesis, the author designs a mobile web-based vaccination service system, to improve the quality of vaccination service, within the low resource setting. A study in HCI is carried out to design a vaccination service system in the low resource settings of Uganda. Through theoretical study, the author collects the knowledge about how to apply HCI theory to system interface design. A related work study is carried out to help the author to choose the design solution. Through comparing the design with related works, the strength of using the author’s design solution in low resource of Uganda is verified. A field study helps to collect information about the user’s characteristics, which is used for designing a user-friendly system interface. An internal focus group helps to improve the design quality. The author delivers a case study example which could be evaluated and borrowed by other researchers who design a similar system. Additionally, findings from the qualitative research could be used for further research. / The goal of this master thesis was to design a mobile web-based vaccination service system to improve the quality of vaccination service for the low resource settings of Uganda. Through the literature and field study about the local situation of vaccination services, the design challenges and the user’s characteristics were stated, and helped the author to identify the system functionality and usability. Additionally, the Nielsen’s 10 HCI criteria were used to influence the interface design, in order to design a user-friendly system. Through the study of related designs, the benefits of using mobile web-based system solutions in this study were discussed: brings mobility and flexibility of usage; enhances the remote communication and data transaction among users; low level of data input error occurrence and quality data storage. These strengths motivated the author to use the mobile web-based system solution.