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Analysis of human vestibular responses to caloric stimulationDemers, Robert. January 1975 (has links)
No description available.
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A symmetrical model for bilateral neural pathways in the vestibulo- ocular reflex /Galiana, Henrietta L. January 1981 (has links)
This thesis presents for the first time a symmetrical, bilateral model of central pathways in the vestibulo-ocular reflex (VOR), based on known neural pathways and their interconnections on both sides of the brainstem. The model explains, simultaneously, the known behaviour of individual neural groups within the system (in central pathways) and of eye movements at its output. It does not require a long time constant "neural integrator" (NI) nor separate pathways for the generation of slow and fast phases of nystagmus, as in previous models. A single "neural filter" (NF, time constant < 1s) on each side of the brainstem is sufficient to provide integration in the slow phase mode, with the help of a positive feedback loop due to commissural innervation. Fast/slow phase alternation of eye movements is achieved through simple modulation of commissural inhibition by reticular burst cells. / Analytic and computer simulation studies show that the model can account, for the first time, for published response characteristics in the vestibular nuclei, and for their dependence on commissural and cerebellar pathways.
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The role of calcium-dependent pathways in vestibular compensationSansom, Andrew J., n/a January 2005 (has links)
Damage to one vestibular apparatus (unilateral vestibular deafferentation, UVD) results in severe postural and ocular motor disturbances (such as spontaneous nystagmus, SN) that recover over time in a process known as vestibular compensation. However, the underlying neurochemical mechanisms of vestibular compensation are poorly understood. While UVD affects many areas in the CNS, attention has focused upon the partially deafferented second order neurons in the vestibular nuclei complex (VNC). Several converging lines of evidence suggest that Ca�⁺-permeable ion channels (N-methyl-D-aspartate receptors and L-type voltage-gated Ca�⁺-channels) and intracellular Ca�⁺-dependent protein kinases play an important role in vestibular compensation. However, the nature of this involvement and the locus of these changes are unknown. The aim of this thesis was to investigate the role of Ca�⁺ signalling pathways in the VNC during vestibular compensation in guinea pig. These issues were investigated in three separate experiments that utilised two methodological approaches: i) in vitro assays were used to determine the nature and extent of protein phosphorylation within the VNC at various stages of compensation; and ii) ion channel blockers or cell-permeable kinase inhibitors were injected directly into the VNC immediately before UVD to determine whether or not these systems were causally involved in compensation.
The results of experiment 1 (Chapter 5) showed that a bolus intra-VNC injection of an uncompetitive NMDA receptor antagonist, but not an L-type voltage-gated Ca�⁺ channel antagonist, temporarily reduced SN frequency at the earliest measurement time (6 hours post-UVD). These results suggested that the initial expression of SN required, in part, the activation of NMDA receptors in the VNC on the side of the UVD, and by inference, Ca�⁺ entry through the ion channel. The results of experiment 2 (Chapter 6) revealed that the medial VNC contains abundant Ca�⁺/calmodulin-dependent and Ca�⁺/phospholipid-dependent protein kinase activities. The same VNC tissue removed from animals at various times after UVD, showed that vestibular compensation is accompanied by specific changes in the phosphorylation of several major protein kinase C substrates. These included an unidentified 46-kDa band, and a 75-kDa band with similar characteristics to the myristoylated alanine-rich C kinase substrate (MARCKS). These results suggest that protein kinase C signalling pathways may be involved in vestibular compensation. The results of experiment 3 (Chapter 7) are consistent with these results showing that intra-VNC infusion of a protein kinase C inhibitor, but not a Ca�⁺/calmodulin-dependent protein kinase II inhibitor, significantly increased SN at the earliest measurement times (6 and 8 hours), but had no effect upon the time taken to achieve compensation or on postural compensation. These results suggest that the induction of SN compensation involves protein kinase C activity in the VNC. Taken together, these findings suggest that the mechanisms underlying the expression of SN (e.g., Ca�⁺ influx via NMDA receptors) are possibly distinct from those that initiate its compensation (e.g., PKC activation). The downstream effects of raised intracellular Ca�⁺ may involve protein kinase C-dependent phosphorylation of key intracellular proteins that initiate long-lasting changes in cellular function within the VNC.
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Female rats show greater sensitivity to high-strength magnetic fields role of vestibular system and estrogen /Cason, Angela Marie. Houpt, Thomas A. January 1900 (has links)
Thesis (Ph. D.)--Florida State University, 2006. / Advisor: Thomas A. Houpt, Florida State University, College of Arts and Sciences, Dept. of Neuroscience. Title and description from dissertation home page (viewed June 12, 2006). Document formatted into pages; contains xiv, 112 pages. Includes bibliographical references.
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Morphometry of hair cell bundles and otoconial membranes in the utricle of a turtle, Trachemys scriptaXue, Jingbing. January 2006 (has links)
Thesis (Ph.D.)--Ohio University, August, 2006. / Title from PDF t.p. Includes bibliographical references.
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The identification of vestibular processing dysfunction in disorders of sensory integrationPenberthy, Marie Louise 20 April 2017 (has links)
No description available.
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Analysis of human vestibular responses to caloric stimulationDemers, Robert. January 1975 (has links)
No description available.
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A symmetrical model for bilateral neural pathways in the vestibulo- ocular reflex /Galiana, Henrietta L. January 1981 (has links)
No description available.
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A comparison of washout filters using a human dynamic orientation modelRiedel, Susan Alice January 1977 (has links)
Thesis. 1977. M.S.--Massachusetts Institute of Technology. Dept. of Aeronautics and Astronautics. / Microfiche copy available in Archives and Barker. / Bibliography: 142-145. / by Susan A. Riedel. / M.S.
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Human visual-vestibular interactions during postural responses to brief fallsWicke, Roger William January 1980 (has links)
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1980. / MICROFICHE COPY AVAILABLE IN ARCHIVES AND ENGINEERING. / Bibliography: leaves 263-276. / by Roger William Wicke. / Ph.D.
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