This study comprised three questions, each posed with the intention of exploring the expression of the neurofilament protein (NF) and mRNA levels in the monkey lateral geniculate nucleus (LGN) and visual cortex. (1) Literature indicates NFs are differentially expressed across the two visual pathways that originate from magnocellular and parvocellular layers in LGN. The results herein suggest that this difference continues at the level of gene transcription for the neurofilament heavy gene. (2) NF expression, assessed by SMI-32 (an antibody that recognizes an epitope of the non-phosphorylated NFs), was investigated as a function of developmental changes occurring during the critical period in area V1 of the vervet monkey visual cortex. The findings indicate that the M pathway develops before the P pathway. (3) The effect of eye enucleation on long-term changes in NF expression was investigated. The results do not support the idea that NF are activity-dependent.

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Thesis (M. Phil.)--University of Hong Kong, 2009. / Includes bibliographical references (leaves 37-45) Also available in print.

Thesis (M.A.)--York University, 2005. Graduate Programme in Psychology. / Typescript. Includes bibliographical references (leaves 128-133). Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://gateway.proquest.com/openurl?url%5Fver=Z39.88-2004&res%5Fdat=xri:pqdiss &rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:MR11747

Visual target acquisition is performed during several daily tasks, often requmng time¬dependent behavioural responses towards stimuli. Information processing during such tasks is subject to bottom-up as well top-down influences, which results in an integrated processing mechanism. It follows that if the underlying neural mechanisms can be elucidated, behaviour towards visual stimuli will be better understood, allowing for the development of visual environments that facilitates desired behavioural response. The current study aimed to develop a systems-level approach according to which the mechanisms that underlie visual target acquisition can be understood, by interpreting psychophysical data in terms of the structural and functional organization of the visual system. Empirical work entailed psychophysical experiments and elaborated on previous studies regarding conspicuity areas around and response time towards visual targets. The rationale was that these two measures can be used as an indication of the conspicuity of a target within a specific background, which in turn can be related to the nature of information processing during a target acquisition task. Results showed that a proportional relationship exists between the size of the conspicuity area and a target's perceived conspicuity, with the most conspicuous targets being associated with the largest conspicuity areas. Response time trends showed that target detectability at different positions within the conspicuity area is equal, but that detection performance at positions outside the conspicuity area is greatly influenced by the nature of the background surrounding the target. Interpretation of the results points to the importance of visual attention during target acquisition, which in turn is supported by the structural and functional organization of the visual system. Findings from the psychophysical study presented here, along with the proposed framework of information processing, emphasise that behavioural outcome during visual target acquisition cannot be explained without considering the structural and functional organization of the visual system. / Dissertation (MSc (Human Physiology))--University of Pretoria, 2006. / Physiology / unrestricted

Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Psychology, 1980. / MICROFICHE COPY AVAILABLE IN ARCHIVES AND HUMANITIES. / Vita. / Bibliography: leaves 133-142. / by Bjorn Hellmut Merker. / Ph.D.

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