Thesis (M.S.)--University of Delaware, 2007. / Principal faculty advisor: Gonzalo Arce, Dept. of Electrical and Computer Engineering. Includes bibliographical references.

The goal of this thesis was to investigate the role of colour in visual selective attention. Previous experiments exploring this topic in tasks where location varied led to mixed results. Some studies only found evidence of colour as a guide to a specific location where selection then takes place (e.g., Nissen, 1985). Others reported an effect, but could not decide clearly if the benefit was due to direct selection of colour in perception (e.g., Humphreys, 1981). One major contributor to the inconsistencies of findings seems to be the confounding of colour and location in these tasks. For that reason the initial paradigm used here was a rapid serial visual presentation (RSVP) task. Previous studies using similar paradigms have found no evidence for direct selection by colour (Poder, 2001; Shih & Sperling, 1996), but in these studies advance colour information was of limited usefulness because it only reduced the set of candidate stimuli by half. To assess an effect of colour in selection similar to the one associated with location, in all experiments reported here valid colour information led to only one item, as is typical in location cuing tasks. The first RSVP experiment explored whether colour certainty improved performance over a colour uncertainty condition. Colour was the defining feature of the target participants had to discriminate. In one condition the target colour was certain; in the other it could be one of two colours. Performance was improved when participants could focus on one colour. Further experiments used colour not as a defining feature of the target but as additional information presented in the form of cues, similar to the typical use of location cues. The participants� task was to discriminate whether a target letter within the RSVP sequence appeared in its upper or lower case version, and an advance cue indicated the colour in which the target letter was most likely to occur. An accuracy benefit of valid colour information was found, supporting the hypothesis that colour cuing allows the direct selection of objects for further perceptual processing. In addition, an effect of invalid colour cues was also observed. Subsequent experiments investigated possible factors influencing the colour cuing effect. Together, task requirements and properties of the stimulus set were shown to have an influence on the effect size, whereas an increase in perceptual load had no impact. Furthermore, the colour cuing effect seems to be due partially to both automatic and strategic processes. In all these experimental variations, benefits of colour cuing remained, indicating that the effect is very robust. Colour cuing effects were also found in a design where location could vary, extending the previous findings from selection in the time domain to selection in space. The two last experiments investigated whether advance colour knowledge would also lead to a performance benefit in single item tasks. No effect of colour cuing was found, indicating that colour information is only helpful in multiple item displays when a selection of one target stimulus among distractor items is necessary.

Thesis (Ph. D. in Neuroscience)--Vanderbilt University, May 2008. / Title from title screen. Includes bibliographical references.

Thesis (M.Phil.)--Hong Kong University of Science and Technology, 2006. / Includes bibliographical references (leaves 72-74). Also available in electronic version.

published_or_final_version / abstract / Psychology / Doctoral / Doctor of Philosophy

Axons are directed along stereotypic pathways to their targets by cues arrayed in the extracellular environment. Identifying the cellular and molecular nature of these signals is of high interest and the developing optic pathway is a useful model system for achieving this. Although previous studies have identified several molecules essential for optic pathway formation, in vivo only subsets of retinal axons rely on them. I focused on the Dscam (Down’s syndrome cell adhesion molecule) and Sidekick (Sdk) cell adhesion molecules for potentially playing crucial roles in this system. In situ hybridisation in the embryonic mouse visual system showed Dscam and Sdk-1 expression in the RGC layer of the retina, along the optic pathway and in the visual targets. Sdk-2 was detected in the glia of the optic nerve and optic chiasm, marking the pathway that RGC axons follow, but not in RGCs. No DscamL1 was detected in RGCs or the optic pathway at the stages investigated and it was discounted from future analysis. In vitro, DSCAM promoted RGC axon outgrowth, whereas SDK 1 was inhibitory. SDK 2 had no effect on RGC axon outgrowth, suggesting it does not play a direct role in their pathfinding. Repeating this assay using retinal explants from the Dscamdel17 mouse mutant, showed that DSCAM enhanced retinal axon outgrowth, at least in part, through homophilic interactions. Analysis of visual system development in Dscam mutants showed DSCAM involvement in RGC axon fasciculation and in enhancing their growth, particularly within the ipsilateral optic tract. Retinal cell counts revealed that DSCAM played diverse roles in controlling cell number. Pre- and postnatal retinas lacking DSCAM contained more RGCs and mitotic cells. Postnatally, Dscam-/- retinas also show decreased cell death. In many cases, defect severity was dose-dependent, with an intermediate phenotype in the heterozygous mice, implicating DSCAM in the neurological defects of Downs’ Syndrome patients.

D.Ing. / The rapid use of digital images and the necessity to compress them, has created the need for the development of image quality metrics. Subjective evaluation is the most accurate of the image quality evaluation methods, but it is time consuming, tedious and expensive. In the mean time widely used objective evaluations such as the mean squared error measure has proven that they do not assess the image quality the way a human observer does. Since the human observer is the final receiver of most visual information, taking the way humans perceive visual information will be greatly beneficial for the development of an objective image quality metric that will reflect the subjective evaluation of distorted images. Many attempts have been carried out in the past, which tried to develop distortion metrics that model the processes of the human visual system, and many promising results have been achieved. However most of these metrics were developed with the use of simple visual stimuli, and most of these models were based on the visibility threshold measures, which are not representative of the distortion introduced in complex natural compressed images. In this thesis, a new image quality metric based on the human visual system properties as related to image perception is proposed. This metric provides an objective image quality measure for the subjective quality of coded natural images with suprathreshold degradation. This proposed model specifically takes into account the structure of the natural images, by analyzing the images into their different components, namely: the edges, texture and background (smooth) components, as these components influence the formation of perception in the HVS differently. Hence the HVS sensitivity to errors in images depends on weather these errors lie in more active areas of the image, such as strong edges or texture, or in the less active areas such as the smooth areas. These components are then summed to obtain the combined image which represents the way the HVS is postulated to perceive the image. Extensive subjective evaluation was carried out for the different image components and the combined image, obtained for the coded images at different qualities. The objective (RMSE) for these images was also calculated. A transformation between the subjective and the objective quality measures was performed, from which the objective metric that can predict the human perception of image quality was developed. The metric was shown to provide an accurate prediction of image quality, which agrees well with the prediction provided by the expensive and lengthy process of subjective evaluation. Furthermore it has the desired properties of the RMSE of being easier and cheaper to implement. Therefore, this metric will be useful for evaluating error mechanisms present in proposed coding schemes.

Thesis (Ph. D.)--University of Hong Kong, 2007. / Title proper from title frame. Also available in printed format.

The studies presented in this thesis address current issues in visual attention and awareness research. The first three experimental chapters investigate saccadic remapping of location and orientation information, with a particular focus on saccadic remapping in hemianopia. The results suggest that residual visual abilities in the blind field are necessary in order for a stimulus to be remapped from the blind to the sighted visual field. The results also suggest that remapping underpins our ability to maintain attention at specific spatiotopic locations across a series of saccades. Further evidence from both hemianopic and neurologically intact participants suggest that some orientation information is remapped across saccades. The second three experimental chapters investigate binocular rivalry in previously unstudied paradigms. The results show that the established face dominance and emotion dominance effects in binocular rivalry persist when the stimuli are viewed in peripheral vision. The results also suggest that a stable image presented in the opposite hemifield from the rival pair does not affect the perceived dominance of the separate images within the rival pair, but that the percepts in the rival pair tend to synchronise with those of a second rival pair presented in the opposite hemifield. Using Diaz-Caneja stimuli (half of each image presented to each eye) the results of the final experiments suggest a combination of eye- and object-dominance mechanisms in binocular rivalry in both the intact and the split-brain.

This study aimed to better understand the clearance of myelin debris during Wallerian degeneration in the goldfish visual paths. Myelin debris was first examined immunohistochemically in the presence or absence of regenerating axons. From these preliminary experiments it was apparent that the clearance of myelin debris was not affected by regenerating axons and that the debris was removed in a differential pattern along the visual pathway. Specifically, in the distal stump of the nerve as well as in the optic tract, myelin debris had been effectively cleared by one-month postoperative, while in the cranial segment of the nerve debris persisted for at least 6 weeks after injury. The differential pattern of myelin debris in the optic nerve and tract was then analyzed qualitatively and quantitatively using thick and thin plastic sections at various time points during regeneration. The results suggested that highly activated peripheral macrophages were responsible for the effective clearance of myelin in the distal nerve stump. In the optic tract a number of cellular properties, including their unique population of astrocytes may have enhanced the rate of debris clearance. By contrast, in the cranial segment of the nerve persistent debris was found both intracellularly in phagosomes and extracellularly, suggesting that the resident phagocytes were deficient in effecting both phagocytosis and emigration. Deficient phagocytosis may be a result of the production of anti-inflammatory cytokines in this region, while the failure to emigrate is most likely due to the rigid network of astrocytes in the nerve.