A research report submitted to the Faculty of Health Sciences Witwatersrand University, Johannesburg in partial fulfillment of the requirements for the degree of Master of Medicine in Family Medicine Johannesburg, South Africa 2017 / Background: Low birth weight (LBW) is an important risk factor for infant developmental problems, morbidity and mortality. Low birth weight babies are twenty times more likely to die during the neonatal period than their normal weight counterparts. Although risk factors for low birth weight vary from one community to another, maternal risk factors for low birth weight in the South Rand Hospital (Johannesburg, Gauteng) catchment area have not been investigated. The objective of this study was to determine maternal risk factors for low birth weight in South Rand Hospital, Johannesburg. Method: This 1: 1 matched case-control study was conducted on a total of 480 mothers who delivered babies at South Rand Hospital between 1 January 2013 and 31 December 2014. The cases were 240 mothers who delivered singleton term live LBW babies. They were matched with an equal number of controls. Results: Conditional logistic regression showed that, no anaemia in the third trimester (OR=0.54, 95% CI= 0.30-0.99), immigration status (OR= 0.46, 95% CI= 0.25- 0.85) and four or more antenatal care clinic attendance (OR=0.36, 95% C.I= 0.12- 0.76) were protective factors, while smoking during pregnancy (OR= 8.69, 95% CI= 2.70-28.35) predisposes to delivering a LBW baby. Conclusion: The results showed that smoking during pregnancy is a risk factor for LBW, while maternal third-trimester haemoglobin level of 11g/dl or more, immigrant status, and more than three ANC visits were protective factors for delivering LBW baby. / MT2017

The purpose of this research was to investigate how accurate trained lifters were at gauging intra-set rating of Perceived Exertion (RPE) in the squat, bench press, and deadlift. Ten resistance-trained males completed four sets to failure with 80% of their one-repetition maximum (1RM) and verbally indicated when they believed they were at a “6” and “9” RPE. Across all sets and all lifts, the called 9 RPE was more accurate than the called 6 RPE. Additionally, RPE calls were more accurate during set four vs. set one on the squat and deadlift at both the called 6 and 9 RPEs. Further bench press RPE calls were more accurate than squat and deadlift RPE at the called 6, while both bench and deadlift RPE calls were more accurate than squat RPEs at the called 9. Importantly across all sets all RPE calls assessed repetitions in reserve within one repetition of precision. / Includes bibliography. / Thesis (M.S.)--Florida Atlantic University, 2018. / FAU Electronic Theses and Dissertations Collection

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Thesis (Ed.D.)--Boston University

This portfolio presents a unique and significant body of research which together provides a substantial, original description and analysis of women’s engagement with weight management behaviours and services during pregnancy. This body of research examines this topic from multiple perspectives, concluding with a detailed interpretative study which sheds light on the deep-rooted determinants of women’s weight-related behaviours during pregnancy. All outputs are articles published in peer-reviewed scientific journals: Article one describes an evaluation of the acceptability of an individual, home-based perinatal weight management service, based on a qualitative examination of the experiences of obese women who used the service during pregnancy. The findings showed that women valued the support they received from the service, and highlighted home visits, personalised advice and regular weight monitoring as beneficial, while suggesting that more frequent appointments and practical support with target behaviours would enhance the service. Article two describes a qualitative study of the views and experiences of obese women who had declined or disengaged from the service evaluated in article one. The study identified the referral experience as key to women’s decisions to decline participation, highlighting the need for midwives and other health professionals to have detailed knowledge of the service and training on how to sensitively offer this additional support. Findings also demonstrated that some obese women lacked the confidence or capability to successfully change weight-related behaviours, even with support, leading them to disengage from the service. Article three compares and combines qualitative data obtained from two sets of midwives, each referring women to either a one to one, home-based weight management service, or a group, community-based weight management service, to explore how midwives approach the referral with obese and overweight women, and their views of women’s responses to being offered a referral. Findings highlighted the important role midwives play as gatekeepers to weight management services and raised questions regarding how midwives approach the referral process within the wider context of the maternal obesity issue. The findings also suggest that services might improve uptake through addressing pragmatic and motivational barriers, and through better communication with their referral agents. Article four describes analysis of qualitative data collected from women who declined a referral to a group, community-based weight management service during their pregnancy, specifically exploring their views on being referred to the service by their midwife. In contrast to the findings described in article two, women in this study reported finding the referral acceptable, and that they expected to receive information about such services from their midwife. The more positive response of these women could be attributed to a number of potential factors, including; an increase in women’s awareness of the risks of maternal obesity, an increase in midwives’ confidence and skill to raise the issue of weight in the time elapsed between the two studies, or a different approach to making the referral between the two services. Article five reports the findings of a qualitative study using Interpretive Phenomenological Analysis (IPA) which sought to explore in detail the lived experience of a first pregnancy and the process of making decisions about diet and physical activity during this time. The article aimed to further illuminate the multiple and significant barriers to adopting positive dietary and physical activity behaviours during pregnancy, and to challenge the commonly cited belief that ‘pregnancy is a good time for behaviour change’ by examining women’s experiences with specific reference to the model of ‘Teachable Moments’ (McBride, Emmons, & Lipkus 2003). While partially supporting the model, the results also indicated that women with healthy, uncomplicated conception and pregnancy experiences base their diet and physical activity choices primarily on automatic judgements, physical sensations and perceptions of what pregnant women are supposed to do, which in turn suggests limited opportunity for antenatal health professionals to intervene and subsequently influence behaviour. These accumulated findings suggest that there is much that can be done to increase obese women’s engagement with maternal weight management behaviours and services. Service providers and commissioners could draw on these findings to design services which better meet the needs of many obese women, such as receiving personalised support, at a time and location convenient for them, and providing regular weight monitoring. There are also implications for health professionals’ education and clinical practice, with findings indicating that midwives would benefit from further training and better information about the weight management services they are asked to refer to, in order to make referrals more evidence-based and increase their confidence to advocate for the service to women who might benefit. Finally, the work presented in this portfolio further informs our understanding of the psychosocial determinants of women’s weight-related behaviour during pregnancy. It suggests that researchers and practitioners should consider how to tackle the largely socially learned, sub-optimal behaviour patterns that are often established in early pregnancy and how to activate more reflective decision-making in relation to diet, physical activity and weight management. The portfolio also includes critical reflection on each of the outputs and the contribution of each unique study to the development of the author into an independent and expert researcher, and concludes with suggestions for future research.

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Objective: Since short-term weight loss is often achievable in overweight individuals but long-term weight maintenance is generally poor, this thesis examines the effect of the nature of support programmes and macronutrient composition on weight maintenance following weight loss. Research design and methods: A 2x2 multifactorial design was used to compare two support programmes and two diets differing in macronutrient composition on maintenance of weight loss over a 2-year period. Two hundred women who had recently lost at least 5% of initial body weight were randomised into one of two support programmes. One provided intensive expert, health professional support with regular circuit training classes. The other provided brief and frequent �weigh-ins� and support facilitated by a nurse. Participants were also randomised with regard to recommended diet composition. One eating plan was high in carbohydrate and dietary fibre, emphasising low glycemic index foods. The second eating plan was relatively high in monounsaturated fat and protein and had a low overall glycaemic load. At baseline, 1 and 2-years, weight, waist circumference and blood pressure were measured and body composition was estimated using bioelectrical impedance. Three-day weighed diet records were collected to estimate dietary intake. A fasting blood sample was used to measure glucose, insulin and lipids. Results: At 2-years weight was measured for 87% of participants. On average those randomised to the Expert Support Programme reduced weight by 2.5kg while those on the Nurse Support Programme reduced weight by 3.6kg (difference between support programmes, P=0.976). On the High Carbohydrate Diet average weight loss was 2.4kg compared with a loss of 3.8kg on the High Monounsaturated fat Diet (difference between diets, P=0.419). At follow-up, there were no signficant differences between the support programmes with regards to body composition, systolic and diastolic blood pressures, blood lipid levels, glucose, insulin, and predicted insulin sensitivity. From a health system perspective and relative to the Nurse Support Programme, the Expert Support Programme cost $NZ 928, 970 per QALY gained (or $9, 290 per person). At follow-up, there were no signficant differences between the dietary prescriptions with regard to body composition, systolic and diastolic blood pressures, triglycerides, HDL-cholesterol, glucose, insulin and predicted insulin sensitivity. However, total and LDL cholesterol were significantly lower on the High Carbohydrate Diet compared with the High Monounsaturated fat Diet (total cholesterol 0.2mmol/l, P=0.044, LDL cholesterol 0.2mmol/l, P=0.042). At follow-up those on the High Monounsaturated fat Diet reported significantly higher intakes of saturated fat (1.5%TE), total fat (5%TE), monounsaturated fat (2.4%), and a significantly lower intake of carbohydrate (-5%TE) than those on the High Carbohydrate Diet. Conclusion: A relatively inexpensive nurse led programme appears to be as effective as a more costly expert health professional led programme in achieving weight maintenance over a 2-year period. This inexpensive and successful weight maintenance programme offers a feasible option for implementation in primary health care in New Zealand. Similarly, both dietary approaches produced comparable beneficial effects in terms of weight loss maintenance. However the High Carbohydrate Diet was associated with lower levels of total and LDL cholesterol, possibly due to a lower intake of saturated fat.

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