Introduction: Very few studies have looked at the effect of vibration on flexibility, and no studies exist that have looked at stretching concurrently with whole body vibration (WBV) training. Therefore, the purpose of this study was to determine if whole-body-vibration training (WBV) done concurrently with static stretch (SV) is more effective than static stretching alone (SS), and to see if WBV training independently (SQ) improves hamstring flexibility without stretching. A secondary purpose of this study is to determine if retention of flexibility gains are maintained. Methods: Forty-four subjects (31 men, 13 women) completed this study (age 22.5 ± 1.8 years; body mass 75.54 ± 13.18 kg; height 176.7 ± 8.06 kg). All subjects were randomly assigned to 1 of 5 groups: SV group (8 males, 3 females), SQ group (8 m, 4 f), SS group (8 m, 3 f), and the C group (7 m, 3 f). All subjects were measured bilaterally for hamstring flexibility using the lying passive knee extension test (LPKE) prior to group assignment. Subjects from each treatment group reported to lab 5 times per week for treatment. Subjects stood on the WBV platform for 5 repetitions of 30-seconds at with 30-seconds in between bouts. The SV group stretched hamstrings while standing on the WBV during the vibration bouts (at 26 Hz and 4 mm amplitude). The SS group did the same thing except the unit was not turned on. The SQ group stood on the WBV platform in a semi-squat position similar to most WBV training studies, without stretching, but with vibration. The C group stood on the WBV platform in a semi-squat without vibration. Analysis and Results: A mixed models analysis of covariance (ANCOVA) was used while blocking on subjects to analyze data using the statistical program SAS (version 9.1). A Bonferroni correction was used for significance on all post hoc tests (p<.0001). At baseline there were no significant differences between groups for flexibility (see Table 1), showing that each group was similar in flexibility to start. Throughout the treatment period (3 weeks of stretching) both the SS and SV groups had significant increases in flexibility compared to SQ and C. Analysis of the slopes (rate of change) for the treatment period was significantly different between the SV group and all other groups (p<.0001 for all comparisons), showing that the SV group had a greater rate of change than all other groups. For the retention period there was no significant difference between the SV and SS group (p=0.0455), but there was a significant difference between both the SV and SS groups and all other groups (p<.0001 for all comparisons). Conclusion: Stretching during WBV improves flexibility more than static stretching alone and at a faster rate. WBV on its own without stretching does not significantly improve hamstring flexibility.

The purpose of this study was to determine if whole body vibration effects strength gains in the bench press, the back squat, and the power clean in division 1 football players. Thirty-one NCAA Division 1 male football players volunteered for this study and were randomly assigned to a control group (C=16) or one of two vibration groups (V1=7, V2=8). Subjects followed the training program for eight weeks. A pre-test, mid-test, and post-test one repetition max was measured at 0, 4, and 8 weeks for the bench press, the back squat, and the power clean. A 3x3 factorial ANOVA revealed varied results between the three lifts performed. In the bench press, there were no significant differences in strength gains between the three training groups (F=.616, p=.547). In addition, there was no significant interaction (F=1.05, p=3.74). There were significant differences between trials in the bench press in strength gains (F=7.570, p=.006). In the back squat, there were no significant differences in strength gains between the three training groups (F=.847, p=.440). In addition, there were no significant differences in interaction (F=1.734, p=1.83). There were significant differences between trials in the back squat in strength gains (F=17.111, p<.001). In the power clean, there were no significant differences in strength gains between the three training groups (F=.666, p=.522). In addition, there were no significant differences in interaction (F=.113, p=.912). There were significant differences between trials in the power clean in strength gains (F2=26.249, p<.001). While all groups registered significant strength gains over trials, there were no significant differences in strength gains between any of the three treatment groups or any of the three dependant variables. It was concluded that whole body vibration does not enhance strength gains in division I football players.

BACKGROUND: Whole body vibration (WBV) platforms are currently used as adjunctive training devices for exercise programs, and have been shown to facilitate flexibility. One of the biggest contributing factors to chronic ankle instability (CAI) is the lack of dorsiflexion after lateral ankle sprains and WBV may be an effective way to increase range of motion in this population. PURPOSE: Determine if WBV done concurrently with static stretching (SS) is more effective then SS alone in improving dorsiflexion ROM in subjects with CAI. METHODS: Subjects were divided into 3 groups (control, static stretch, and static stretch and vibrate). Subjects stretched 4 days/wk for 3 wks for 4 sets of 30 seconds alternating 2 different positions to stretch both the soleus and the gastrocnemius. Imposed vibration at 34 Hz 2mm during the stretches for the stretch group. ANALYSIS: Repeated measures ANOVA was performed using SPSS (version 19), with post-hoc Tukey tests as needed (p<.05). RESULTS: In both the straight and bent leg position, a significant group x time interaction was found for dorsiflexion range of motion. Post hoc tests revealed significance in the SV group between pre-tx and post-tx 1 and pre-tx and post-tx 2. No statistical significance was found between post-tx 1 and post-tx 2 in the SV group or at any time in the N or SS group. DISCUSSION: Static Stretching with vibration increases dorsiflexion ROM in subjects with CAI better than static stretching alone.

A pig model of childhood obesity was used to study the effects of dietary energy on body adiposity, and blood parameters associated with impaired glucose clearance. Prepubertal female pigs weaned at 21 d of age were fed control (CON), refined sugar (SUG), fat (FAT), and sugar-fat (SUGFAT) diets in a completely randomized arrangement for 16 wk. Calories from fat were 8.9% for CON, 5.6% for SUG, 35.5% for FAT and 32.3% for SUGFAT. Calories from sugar were 36.0% for SUG and 30.7% for SUGFAT. Adding fat, sugar or both to diets increased (P < 0.003) calorie intake. Percentage body fat was higher (P < 0.0001) in all treatments compared to CON, and in SUGFAT and FAT compared to SUG. Ultrasound back fat depth was positively correlated (r2 = 0.909; P < 0.001) with percentage body fat and negatively (r = 0.912; P-value ) with percentage body protein. Area under the curve (AUC) in response to oral glucose tolerance at 14 wk was higher (P < 0.03) in FAT (+14.6%) and SUGFAT (+25.5%) pigs compared to CON. Glucose AUC from sugar-fed pigs was not different (P = 0.2) from fat alone-fed pigs. Adding sugar, fat, or their combination to diets increased (P < 0.008) blood glucose and decreased (P < 0.0009) plasma insulin AUC. These data show that inclusion of fat and refined sugar in pig diets increases body adiposity and impairs glucose homeostasis and suggests that the composition of calories consumed may have different effects than simply consumption of excess of calories. / Master of Science

Metabolic Syndrome (MetS) is a cluster of metabolic disorders that substantially increase the risk of developing other chronic diseases such as cardiovascular disease and type II diabetes. Diet is known to play a crucial role in the development of MetS and dietary intervention studies are a useful tool to investigate the effect of diet on MetS. However, the slow onset of MetS and difficulties associated with adhering to new diets, especially for long-term, makes it challenging to perform extensive dietary intervention studies on humans. To overcome this limitation, we sought to investigate the impact of diet on the risk of MetS by taking an in silico systems biology approach. We employed a whole-body model (WBM) of metabolism that accounts for 26 organs, including six sex organs, to computationally evaluate, at genome-scale, the effect of ten different diets on the serum levels of five key metabolites implicated in MetS namely glucose, triacylglycerides (TAG), LDL-C, HDL-C, and palmitoyl-CoA. We performed separate simulations for males and females using the sex specific WBMs. Our analyses elucidated molecular mechanisms that support the current hypothesis that an unhealthy diet can significantly elevate the risk of developing MetS while a healthy diet helps promote metabolic homeostasis. Furthermore, our investigation uncovered novel insights into the contribution of specific organs and tissues to the risk of MetS under these diets in males and females. For example, we found that glucose and TAG secretion by adipocytes into the blood are substantially lower and higher, respectively, under the unhealthy diet compared to other diets. Striking differences were also observed between the unhealthy diet and other diets for LDL-C, HDL-C, and palmitoyl-CoA in males. In females, we observed patterns that resembled those in males although other organs, such as the breast or uterus, also contributed to the serum levels of these key metabolites. Our study offers a promising strategy for investigating the effect of various dietary regimens on human metabolism and MetS at organ-level resolution. This paves the way for the in silico design of new dietary interventions to treat MetS. / 2026-02-12T00:00:00Z

No description available.

Powered exoskeletons have the potential to revolutionize the labor workplace across many disciplines, from manufacturing to agriculture. However, there are still many barriers to adoption and widespread implementation of exoskeletons. One major research gap of powered exoskeletons currently is the development of a control framework to best cooperate with the user. This limitation is first in understanding the physical and cognitive interaction between the user and exoskeleton, and then in designing a controller that addresses this interaction in a way that provides both physical assistance towards completing a task, and a decrease in the cognitive demand of operating the device. This work demonstrates that multi-objective, optimization-based control can be used to provide a coincident implementation of autonomous robot control, and human-input driven control. A parameter called 'acceptance' can be added to the weights of the cost functions to allow for an automatic trade-off in control priority between the user and robot objectives. This is paired with an update function that allows for the exoskeleton control objectives to track the user objectives over time. This results in a cooperative, powered exoskeleton controller that is responsive to user input, dynamically adjusting control autonomy to allow the user to act to complete a task, learn the control objective, and then offload all effort required to complete the task to the autonomous controller. This reduction in effort is physical assistance directly towards completing the task, and should reduce the cognitive load the user experiences when completing the task. To test the hypothesis of whether high task assistance lowers the cognitive load of the user, a study is designed and conducted to test the effect of the shared autonomy controller on the user's experience operating the robot. The user operates the robot under zero-, full-, and shared-autonomy control cases. Physical workload, measured through the force they exert to complete the task, and cognitive workload, measured through pupil dilation, are evaluated to significantly show that high-assistance operation can lower the cognitive load experienced by a user alongside the physical assistance provided. Automatic adjustment in autonomy works to allow this assistance while allowing the user to be responsive to changing objectives and disturbances. The controller does not remove all mental effort from operation, but shows that high acceptance does lead to less mental effort. When implementing this control beyond the simple reaching task used in the study, however, the controller must be able to both track to the user's desired objective and converge to a high-assistance state to lead to the reduction in cognitive load. To achieve this behavior, first is presented a method to design and enforce Lyapunov stability conditions of individual tasks within a multi-objective controller. Then, with an assumption on the form of the input the user will provide to accomplish their intended task, it is shown that the exoskeleton can stably track an acceptance-weighted combination of the user and robot desired objectives. This guarantee of following the proper trajectory at corresponding autonomy levels results in comparable accuracy in tracking a simulated objective as the base shared autonomy approach, but with a much higher acceptance level, indicating a better match between the user and exoskeleton control objectives, as well as a greater decrease in cognitive load. This process of enforcing stability conditions to shape human-exoskeleton system behavior is shown to be applicable to more tasks, and is in preparation for validation with further user studies. / Doctor of Philosophy / Powered exoskeletons are robots that can be worn by users to physically aid them in accomplishing tasks. These robots differ in scale, from single-joint devices like powered ankle supports or lower-back braces for lifting, to large, multi-joint devices with a broad range of capabilities and potential applications. These multi-joint exoskeletons have been used in many applications such as medical rehabilitation robots, and labor-assisting devices for enhancing strength and avoiding injury. Broader use and adoption in industry could have a great positive impact on the experience of workers performing any heavy-labor tasks. There are still barriers to widespread adoption, however. When closely interacting with machinery like a powered exoskeleton, workers want guarantees of saftey, trust, and cooperation that current exoskeletons have not been able to provide. In fact, studies have shown that industrial devices capable of providing significant assistive force when accomplishing a task, also tend to impart additional, uncomfortable disturbance forces on the user. For example, a lower-body exoskeleton meant to help in lifting tasks might make the simple act of walking more difficult, both physically and mentally. There is a need for exoskeletons that are intuitively cooperative, and can provide both physical assistance towards completing a task and cognitive assistance that makes coordinating with the human user easier. In this dissertation we examine the control problem of powered exoskeletons. In the past, many powered exoskeleton controllers are direct, scripted controllers with exact objectives, or actions tied only to human input. To go beyond this, we leverage "multi-objective-control", originally designed for humanoid robots, which is capable of controlling the robot to accomplish multiple goals at the same time. This approach is the base on which a more complex controller can be created. We show first that the multi-objective control can be used to achieve human desired actions and robot autonomous control tasks at the same time, with a parameter to trade-off which actor, the human or the robot, has the priority control at that time. This framework has the capacity to allow the human to instruct the robot in tasks to accomplish, and then robot can fully mimic the user, offloading the physical effort required to accomplish the task. It is proposed that this offloading of effort from the user will also lower the cognitive load the user is under when actively commanding the exoskeleton. To test this hypothesis, a user study is conducted where human operators work with an upper-body powered exoskeleton to complete a simple reaching task. This study shows that on average, the more assistance the exoskeleton provides to the user, the lower their mental demand is. Additionally, when responding to new challenges or sudden disturbances, the robot can easily cooperate, balancing its own autonomy with the user's to allow the user to respond as they need to their changing environment, then resume active assistance when the change is resolved. Finally, to guarantee that the exoskeleton responds quickly and accurately to the user's intentions, a new strategy is derived to update the robot's internal objectives to match the users' goals. This strategy is based on the assumption that the exoskeleton knows what type of task the user is trying to complete. If this is true, then the exoskeleton can estimate the users objectives from the actions they task, and ensure assistance towards completing the task. This control design is proven in simulation, and in preparation for followup studies to evaluate the user experience of this improved strategy.

Professional drivers of off-road vehicles, driving on irregular terrain such as in forestry, agriculture and mining, are exposed to whole-body vibration and mechanical shocks. These driver groups have reported severe musculoskeletal problems in the spine, but the association to seated postural reactions is not fully understood. One assumption is that unexpected shocks may create excessive load on spinal joints. The driver’s posture and exposure to mechanical shocks are required to be included in work risk assessments, but muscle activity and body kinematics are not included. The overall aim of this thesis was to describe and analyse seated postural reactions to mechanical shocks and to evaluate measuring of seated postures with relevance for risk assessment and the prevention of musculoskeletal disorders among drivers. The thesis includes four studies, all laboratory-based using a repeated-measures design. Postural reactions were recorded from 23 (Paper I) and 20 (Paper II &amp; III) young, healthy male participants who were seated on a movable platform. The platform delivered mechanical shocks with peak accelerations up to 14 m/s2 in lateral directions during different conditions. Furthermore, twenty participants (Paper IV) were tested by four testers for analysis of test-retest reliability within and between testers measuring seated postures. Kinematics were here detected by means of a motion analysis system (MoLabTM) and described for the spine as angular displacements or range of motion (ROM) using a three-segment model of neck, trunk and pelvis (Paper I–III) and as a more specific model (Paper IV). Surface electromyography (EMG) was recorded bilaterally on the following muscles; trapezius upper part, upper neck, erector spinae and external oblique (Paper I–III). The general findings show that EMG amplitudes normalised to maximum voluntary contractions (MVC) did not exceed 2% in the trapezius, 8% in the upper neck and erector spinae and 18% in the external oblique. The EMG amplitudes and the angular displacements in the neck were significantly reduced from the first compared to the fifth mechanical shock. Adding a cognitive task significantly increased angular displacements. The largest ROM with approximately 20° in each segment was found during a double-sided mechanical shock (shock that changes direction). The reliability within one tester measuring seated postures was mostly considered good and superior to the reliability between several testers, but still insensitive to changes of less than 10°. Exposure to single-sided or double-sided mechanical shocks with accelerations up to 14 m/s2 seem not to cause postural reactions to such an extent that overload of muscles or joint structures should be expected. There seems to be a quick adaptation that causes an improved readiness. The external obliques were most active when restoring equilibrium and seem important for stabilising the whole spinal column. Stability training, in order to improve neuromuscular control of the external obliques could, therefore, be a possible recommendation. The angular displacement in the neck increases if the subject solves a cognitive task of why such activities should be avoided when driving in difficult terrains. Since accurate descriptions of the spinal posture seems difficult even when advanced technical equipment is used, simpler models seem more appropriate. The results show that postural control is maintained even when exposed to considerable mechanical shocks. On the basis of these results, there is no need to change established risk assessment models.

No description available.

The optimisation of image quality in medical imaging techniques is a significant factor in favourable patient prognoses. The number of counts in a nuclear medicine image is one factor in determining the diagnostic value of the image. The current study aims to determine the variation in counts in whole-body bone scan images with patient height and weight. Three separate studies were undertaken as part of the investigation. First, 65 whole-body bone scans were analysed together with patient height, weight, age and sex. Weight was found to the most important anatomy influence on image counts. However, significant influences from patient sex and age meant that a useful relationship between image counts and patient anatomy based solely on height and weight could not be determined. For the second study, a model of General Electric Millennium MG gamma camera was created and validated within the SIMIND Monte Carlo software. The results indicate that the model is an accurate representation of the gamma camera. Third, the 4D NCAT whole-body patient phantom was modified to represent the average male and female clinical study participants. The phantoms were used in conjunction with the gamma camera model to simulate the whole-body bone scan procedure. The counts in the simulated images were consistent with the average measured counts of the clinical study indicating that it is feasible to use the NCAT phantom for nuclear medicine bone imaging. However, the phantom’s method of activity distribution should be refined to allow a more realistic distribution of activity throughout the skeleton.