Computer technology has advanced rapidly in the past few decades and computers have become a very important and powerful tool in our everyday lives. Prolonged computer use by office workers has been reported to result in an increased risk of developing Work-related Neck and Upper Limb Disorders (WRNULD) (Bernard et al.. 1994: Faucett & Rempel. 1994: Tittiranonda et al.. 1999). The occupational risk factors associated with prolonged computer use include static posture and the speed and force of keyboard operation. Past studies have examined different aspects of these risk factors through measuring muscle electrical activity (EMG), kinematics and keyboard forces. However, most of these studies have been conducted on healthy painfree subjects and even the few Case-Control studies have not clearly established any direct relationships between the risk factors and WRNULD. The present research project consisted of a series of three studies aimed at investigating whether there were intrinsic differences among different individuals in response to different physical stressors. These intrinsic differences may have important implications to help explain why some individuals would develop WRNULD while others do not. The individuals' responses to the demands of three physical stressors: static posture, speed and force of keyboard operation were assessed. The internal exposure measures of kinematics, EMG, keyboard dynamics and subjective discomforts were used to evaluate the inter-individual differences. Study I was a field investigation comparing the neck-shoulder kinematics between symptomatic ("Case", n=8) and asymptomatic ("Control", n=8) office workers. Results showed trends for consistently greater head tilt and neck flexion angles, and greater ranges of movements in the Case Group than the Control Group. / The Case Group also exhibited a trend for increased acromion protraction compared to the Control Group. The Case Group also reported significantly greater discomfort scores compared to the Control Group. Neither the discomforts nor the kinematics displayed any significant changes over a working day. Study 2 was a laboratory study comparing the responses of Case and Control Groups in terms of EMG, kinematics and subjective discomforts, while a standardised computer task was performed continuously for one hour. The responses of Case (n=23) and Control (n=20) Groups were compared to examine the effects of static posture. The results showed similar trends to those in Study I, with increased neck flexion mean angles and ranges of movements in the Case Group compared to the Control Group. In terms of EMG results, there were trends for EMG amplitude differences in the right upper trapezius (UT) and cervical erector spinae (CES) muscles between Case and Control Groups. These trends became statistically significant when the Case subjects were sub-divided into the High (n=15) and Low (n=8) Groups based on their mean discomfort scores. Study 3 was also a laboratory study to compare the Case (n=21) and Control (n=20) Groups when they were challenged by the physical stressors of speed and force of keyboard operation. In this study, each subject's EMG and discomforts were examined in three typing conditions of normal speed and force, increased typing speed and increased typing force. The Case Group showed trends for higher increases in both UT and CES muscle activities than the Control Group, and when divided into the High-Low Groups, the High Group (n=8) showed trends for much higher muscle activities in all three conditions. / Beside muscle activity changes, the High Group subjects also demonstrated a trend for much higher within-subject Speed and Force Variabilities in their keystroke performance, compared to the Low Group and the Control Group. This result implied that the High Group subjects had a more erratic motor control of the keystroke actions. Based on these results, conceptual models were developed to describe the relationships among the physical stressors, internal exposure responses and discomforts. The Altered Motor Control Model refers to the programmed changes in motor control strategies involving muscle recruitment and joint movement patterns, and these changes were closely related to the subjects' musculoskeletal discomforts. The Heightened Sensitivity Model describes the higher sensitivity levels of individuals with more severe discomforts, in response to the demands of physical stressors. These models are closely related and heightened sensitivity may be an 'effect-modifier" of the motor control mechanisms and the perception of discomforts or pains within the individual. In conclusion, the present research has identified important differences between individuals on the basis of their motor control strategies which may contribute to the development of WRNULD. While the present research has mainly examined the individual responses to three physical stressors, it is possible that the models developed may be applicable to other physical stressors. These findings may also have important implications for future ergonomic research, emphasising the need to address interindividual differences in ergonomic interventions to workers. Further research should be directed towards better understanding of these intrinsic individual differences in both physical and non-physical factors that contribute to the development of WRNULD.

Low-load repetitive work (LLRW) and mental load are important risk factors for the development of workrelated muscle pain. The link between these risk factors and the development of pain is still not understood, but stimulation of chemo-sensitive receptors in the muscle probably plays an important role. It has been suggested that sensitising substances may accumulate in the muscle during LLRW, especially when combined with mental load. The overall purpose of this thesis was to try to shed some light on the effects of LLRW on the concentration of sensitising substances (glutamate, prostaglandin E2 (PGE2), norepinephrine (NE)) and on metabolism (lactate, pyruvate and oxygenation) in the trapezius muscle of healthy controls (CON) and subjects with trapezius myalgia (TM). A first step was to investigate whether females with TM exhibit higher absolute concentrations of glutamate and PGE2 in the affected muscle during rest. Using Microdialysis (MD) females with TM and asymptomatic controls were studied during four hours of rest. [Glutamate] and [PGE2] during rest did not differ between groups. A second step was to investigate, in a simulated occupational setting, the effects of LLRW on the concentration of sensitising substances and metabolism in the trapezius muscle of TM and CON, and whether increased work duration resulted in a progressive effect. Asymptomatic females were studied during baseline rest, 30 versus 60 min work and recovery, using MD and near infrared spectroscopy (NIRS). Subjects with TM were studied during baseline rest, 30 min work and recovery. [Glutamate] and [lactate] increased in response to work, but not progressively with increased work duration. [Glutamate] was at all time points significantly lower in TM. [PGE2]and oxygenation remained unchanged during work for CON, while for TM oxygenation decreased significantly during work. In TM [pyruvate] increased during both work and recovery, and a significant interaction between groups was found for [pyruvate] during recovery; while moderately increased in CON it increased progressively in TM. The effects of LLRW with and without superimposed mental load on intramuscular [NE], muscle activity and oxygen saturation in the trapezius were also investigated and compared. Using MD, electromyography and NIRS, healthy females were studied on two occasions; during 30 min LLRW and during 30 min LLRW with superimposed mental load. During work [NE], and muscle activity, were increased, while oxygenation decreased, but no differences between occasions. However, recovery of [NE] to baseline was slower after LLRW with superimposed mental load. The findings of the present thesis suggest: (i) no inflammation, or increased interstitial [glutamate] in TM; (ii) LLRW causes an increased anaerobic metabolism in both TM and CON; (iii) no effect of work duration was found; (iv) a significant difference in the effects of LLRW on the interstitial milieu of the trapezius muscle in TM as compared to CON; (v) LLRW causes a significant increase in [NE], but superimposed mental load does not cause a further increase; (vi) LLRW with a superimposed mental load may result in a slower recovery to baseline [NE] as compared with LLRW alone.