Up to now the issue of the safety and healthy is important in this sociality. More and more young people first select the high economical scale, high popularity, high potential and good system company when entering the work place. The primary reason is that those large enterprises provider good salary, good welfare and upgrade overall value by myself. The most important that the large enterprises obtain the TOSHMS certified and have the perfect occupational safety and healthy management system. In 2010 the Council of Labor Affairs has a mission to enhance the quality of its manpower, to create a friendly working environment, to promote harmonious labor relations, to achieve the dignity of labor and labor to constract equality, human, safety, dignity of working life. In recently years the workplace health promotion activity, employee health concepts into the workplace, it is the best choice for creating a friendly workplace. Moreover, if it can improve employee health through the means of achieving the purpose of workplace safety, not only to benefit both employers and employees, the public is in line with national expectations. Therefore, the research led by the research variables of safety leadership, safety climate, workplace health promotion measures, the Occupational Safety and Health performance, through TOSHMS certified institutions for the research to explore adding workplace health promotion measures on occupational safety and health performance is there a better show. So, the research used an A volumn with multiple B volumns way of sending survey questionnaires 140 volumns of A (the occupational safety and healthy performance of the enterprises), 841 volumns of B (the view of employees for safety leadership, safety climate and workplace health promotion measures). After recycled the valid questionnaires were 50 volumns of A, 266 volumns of B and analysis was conducted via Confirmatory Factor Analysis, CFA, Descriptive Statistics, Independent t-test, One-way ANOVA, Structural Equation Modeling (SEM), Multiple Linear Regression Analysis and so on. Research results reveal that safety leadership and saety climate in the occupational safety and health performance has significant positive impact and safety climate has mediation affection between safety leadership and the occupational safety and healthy performance. Other, workplace health promotion measures and safety climate in the interaction of occupational health and workplace health promotion measures has moderating affection between safety climate and the occupational safety and healthy performance. The contributions of this research include providing Taiwan enterprises with a reference for development strategy on workplace health promotion measures, and to apply the knowledge to labor-related fields and enterprise practices.