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Absence of Sodium Appetite in Cyclophosphamide and DOCA Treated House Mice

Intraperitoneal administration of cyclophosphamide 100 mg/kg and 200 mg/kg significantly lowered plasma sodium and significantly increased plasma potassium but did not result in saline preference in a strain of wild-derived house mice given a choice between water and saline (0.15M) to drink. Deoxycorticosterone acetate treatment in dosages up to 1.5 mg for four days also failed to increase salt intake. The data suggest a possible absence of a sodium appetite mechanism in this species.

Identiferoai:union.ndltd.org:ETSU/oai:dc.etsu.edu:etsu-works-13837
Date01 January 1977
CreatorsPasley, J. N., Koike, T. I., Neldon, H. L.
PublisherDigital Commons @ East Tennessee State University
Source SetsEast Tennessee State University
Detected LanguageEnglish
Typetext
SourceETSU Faculty Works

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