Die Promotionsarbeit untersucht den Zusammenhang zwischen Telomerlänge und Dickdarmkrebs. Sie besteht aus einem Systematic Review und Meta-Analyse und einer prospektiven Kohorte aus 92 Patient*innen mit DIckdarmkrebs und deren Überleben in Abhängigkeit der Leukozyttelomerlängen.:Inhaltsverzeichnis
Seitenzahl
1.
1.1
1.2
1.3
1.4
1.5
1.5.1
1.5.2
1.6
1.6.1
1.6.2
Einführung / Introduction
Colorectal cancer in the United States and in Germany – epidemiology and prevention
Biomarkers as a tool for colorectal cancer prevention and prediction
The role of telomeres and telomere length in cancer, including colorectal cancer
The challenges of telomere-related studies
First publication: Meta-Analysis on telomere length and colorectal cancer risk and survival
Rationale
Research strategy
Second publication: Prospective cohort study on the association of circulating leukocyte telomere length with survival in patients with colorectal cancer
Rationale
Research strategy
3-10
2.
Publikationsmanuskript / Publication: “Association of Telomere Length with Colorectal Cancer Risk and Prognosis: A Systematic Review and Meta-Analysis”
11-24
3.
Publikationsmanuskript / Publication: “Association of circulating leukocyte telomere length with survival in patients with colorectal cancer”
25-31
4.
Zusammenfassung / Summary
32-36
5.
Literaturverzeichnis / References
37-41
6.
6.1
6.2
Anlagen / Supplementary materials
Supplementary material for the publication: “Association of Telomere Length with Colorectal Cancer Risk and Prognosis: A Systematic Review and Meta-Analysis”
Supplementary material for the publication: “Association of circulating leukocyte telomere length with survival in patients with colorectal cancer”
42-54
7.
Darstellung des eigenen Beitrags / Authorship contribution disclosure
55
8.
Selbstständigkeitserklärung / Statement of authorship
56
9.
Lebenslauf / Curriculum Vitae
57
10.
10.1
10.2
Publikationen / Publications
Peer-reviewed journal articles
Poster presentations
58-59
11.
Danksagung / Note of thanks
60Inhaltsverzeichnis
Seitenzahl
1.
1.1
1.2
1.3
1.4
1.5
1.5.1
1.5.2
1.6
1.6.1
1.6.2
Einführung / Introduction
Colorectal cancer in the United States and in Germany – epidemiology and prevention
Biomarkers as a tool for colorectal cancer prevention and prediction
The role of telomeres and telomere length in cancer, including colorectal cancer
The challenges of telomere-related studies
First publication: Meta-Analysis on telomere length and colorectal cancer risk and survival
Rationale
Research strategy
Second publication: Prospective cohort study on the association of circulating leukocyte telomere length with survival in patients with colorectal cancer
Rationale
Research strategy
3-10
2.
Publikationsmanuskript / Publication: “Association of Telomere Length with Colorectal Cancer Risk and Prognosis: A Systematic Review and Meta-Analysis”
11-24
3.
Publikationsmanuskript / Publication: “Association of circulating leukocyte telomere length with survival in patients with colorectal cancer”
25-31
4.
Zusammenfassung / Summary
32-36
5.
Literaturverzeichnis / References
37-41
6.
6.1
6.2
Anlagen / Supplementary materials
Supplementary material for the publication: “Association of Telomere Length with Colorectal Cancer Risk and Prognosis: A Systematic Review and Meta-Analysis”
Supplementary material for the publication: “Association of circulating leukocyte telomere length with survival in patients with colorectal cancer”
42-54
7.
Darstellung des eigenen Beitrags / Authorship contribution disclosure
55
8.
Selbstständigkeitserklärung / Statement of authorship
56
9.
Lebenslauf / Curriculum Vitae
57
10.
10.1
10.2
Publikationen / Publications
Peer-reviewed journal articles
Poster presentations
58-59
11.
Danksagung / Note of thanks
60
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:93823 |
| Date | 20 September 2024 |
| Creators | Pauleck, Svenja |
| Contributors | Universität Leipzig |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:doctoralThesis, info:eu-repo/semantics/doctoralThesis, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
Page generated in 0.0024 seconds