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Previous issue date: 2016-03-30 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / Kalanchoe pinnata (KP) is popularly used for treating inflammatory diseases. This study
investigated the antinociceptive and anti-inflammatory potential of the KP flower aqueous
extract (KPFE), the ethyl acetate (EtOAcF), butanol (BuOHF) and aqueous (AqF) fractions
and the main flavonoid [quercetin 3-O-?-L-arabinopyranosyl (1??) ?-L-rhamnopyranoside]
(KPFV) of KP, as well as possible mechanisms of action. Swiss albino mice, male (25-35g)
were pretreated with KPFE (30-300 mg/kg, s.c.) producing dose-related inhibition of acetic
acid-induced writhing (ID50 164.8 mg/kg), and the subcutaneous administration of KPFE (300
mg/kg), EtOAcF (12 mg/kg), BuOHF (15 mg/kg) or AqF (210 mg/kg) reduced leukocyte
migration on carrageenan-induced pleurisy in mice at 56.1%, 47.3%, 39.6% and 43.1%,
respectively. At doses of up to 240 times smaller than KPFE, KPFV (0.3-3.0 mg/kg, s.c.), also
inhibited leukocyte migration (ID50 1.78 mg/kg). In croton oil-induced ear edema in mice,
KPFE (3-30 mg/kg, s.c.) and KPFV (0.3-3.0 mg/kg, s.c.) presented dose-related antiedematogenic
activity (KPFE - ID50 4.3 mg/kg, KPFV - ID50 0.76 mg/kg). Treatment with
KPFE reduced the MPO and TNF-? concentration in the pleural exudates on carrageenaninduced
pleurisy test, while KPFV inhibited both isoforms of cyclooxygenase (COX), with
IC50 3.8 x 10-5 M (22.1 ?g/mL) for COX-1 and a maximum COX-2 inhibition of 43.5% (IC50
>8.4 x10-5M or 50 ?g/mL). The selectivity index (COX-1 IC50/COX-2 IC50) was <0.44. These
results indicate that KPFE and KPFV produced anti-inflammatory and antinociceptive activity
through the COX inhibition and TNF-? reduction. This study reveals that the main flavonoid
in KP flowers and leaves plays an important role in the ethnomedicinal use of this species for
healing inflammatory processes / Kalanchoe pinnata (KP) ? popularmente utilizada para tratamento de doen?as inflamat?rias.
Este estudo investigou o potencial antinociceptivo e anti-inflamat?rio do extrato aquoso das
infloresc?ncias de KP (EAFL), a fra??o acetato de etila (FAcOEt), a fra??o butan?lica
(FBuOH), a fra??o aquosa (FAq) e o flavonoide majorit?rio [quercetina 3-O-?-Larabinopiranosil
(1??) ?-L-ramnopiranos?deo] (KPFV) de KP, assim como poss?veis
mecanismos de a??o. Camundongos albinos, machos (25-35g) foram pr?-tratados com EAFL
(30-300 mg/kg, s.c.), produzindo inibi??o dose dependente das contor??es induzidas por ?cido
ac?tico (DI50 164,8 mg/kg), e a administra??o subcut?nea de EAFL (300 mg/kg), FAcOEt (12
mg/kg) ou FBuOH (15 mg/kg) reduziu a migra??o leucocit?ria na pleurisia induzida por
carragenina em camundongos em 56,1%, 47,3%, 39,6% e 43,1%, respectivamente. Em doses
at? 240 vezes menores que o EAFL, KPFV (0,3-3,0 mg/kg, s.c.), tamb?m foi capaz de inibir a
migra??o leucocit?ria (DI50 1,78 mg/kg). No teste do edema de orelha induzido por ?leo de
cr?ton em camundongos, EAFL (3-30 mg/kg, s.c.) e KPFV (0,3-3,0 mg/kg, s.c.) apresentaram
atividade antiedematog?nica dose dependente (EAFL - DI50 4,3 mg/kg, KPFV - DI50 0,76
mg/kg). O tratamento com EAFL reduziu a concentra??o de MPO e de TNF-? no exsudato
pleural obtido do teste da pleurisia induzida por carragenina, enquanto o KPFV inibiu ambas
as isoformas de cicloxigenase (COX), com CI50 3,8 x 10-5M (22,1 ?g/mL) para COX-1 e um
m?ximo de inibi??o da COX-2 de 43,5% (CI50 >8,4 x10-5M ou 50 ?g/mL). O ?ndice de
seletividade (COX-1 CI50/COX-2 CI50) foi < 0,44. Estes resultados indicam que EAFL e
KPFV produziram atividade anti-inflamat?ria e antinociceptiva envolvendo a inibi??o da
COX e a redu??o de TNF-?. Este estudo revela que o principal flavonoide presente nas
infloresc?ncias e folhas de KP possui papel importante no uso etnomedicinal desta esp?cie
nos processos de natureza inflamat?ria
| Identifer | oai:union.ndltd.org:IBICT/oai:localhost:jspui/1802 |
| Date | 30 March 2016 |
| Creators | Ferreira, Raquel Teixeira |
| Contributors | Vanderlinde, Frederico Argollo, Silva, Alba Cen?lia Matos da, Malvar, David do Carmo, Pinto, Marcelo Alves, C?rtes, Wellington da Silva |
| Publisher | Universidade Federal Rural do Rio de Janeiro, Programa Multic?ntrico de P?s-Gradua??o em Ci?ncias Fisiol?gicas, UFRRJ, Brasil, Instituto de Ci?ncias Biol?gicas |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da UFRRJ, instname:Universidade Federal Rural do Rio de Janeiro, instacron:UFRRJ |
| Rights | info:eu-repo/semantics/openAccess |
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