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Previous issue date: 2016-02-29 / According to INCA (National Institute of Cancer) the cases of skin cancer are increasing exponentially, and it is the world's largest incidence. The increase in ultraviolet index, due to the depletion of the ozone layer, and excessive sun exposure contribute to this fact. The formation of reactive oxygen species (ROS) can be from endogenous and exogenous factors, mainly by exposure to ultraviolet (UV). This are directly linked to the development of several types of cancer, especially skin cancer and photoaging. ROS or free radicals alter the DNA and other biomolecules of the skin, causing genetic mutations that promote and induce cancer incidence. Consequently, the search for new antioxidant substances for topical use is of utmost importance for the prevention of photodamage and skin cancer. This project of master dregree aims to develop a topical nanoemulsion containing these active substances Green tea (Camellia sinensis) and Buriti Oil (Mauritia flexuosa), which have antioxidant properties, and to study their stability in vitro and assess its properties. As a result it is expected to develop a cosmetic raw material that meets a demand of the consumer market, contributing to the prevention of skin cancer and to decrease the signs of cutaneous photoaging. / Segundo o INCA (Instituto Nacional de C?ncer), o c?ncer de pele possui a maior incid?ncia mundial e seus casos v?m aumentando exponencialmente. O aumento do ?ndice ultravioleta devido ? diminui??o da camada de oz?nio e a exposi??o solar excessiva contribuem para este fato. A forma??o de esp?cies reativas de oxig?nio (EROs), se d? por fatores end?genos e ex?genos, principalmente pela exposi??o aos raios ultravioleta (UV). Esta est? diretamente ligada ao desenvolvimento de diversos tipos de c?ncer, especialmente o de pele. As EROs, ou radicais livres, alteram o DNA e demais biomol?culas da pele, ocasionando muta??es gen?ticas que favorecem e induzem a incid?ncia de c?ncer, e causam fotoenvelhecimento. Consequentemente, a busca de novos ativos com propriedades antioxidantes de uso t?pico ? de extrema import?ncia para a preven??o de fotodanos e c?ncer de pele. Este projeto de mestrado teve como objetivo desenvolver uma nanoemuls?o t?pica contendo estas subst?ncias ativas, Ch? Verde (Camellia sinensis) e ?leo de Buriti (Mauritia flexuosa), que apresentam propriedades antioxidantes, estudar sua estabilidade e avaliar in vitro suas propriedades. Como resultado, espera-se obter um insumo cosm?tico que atenda uma demanda do mercado de consumidores, contribuindo para preven??o do c?ncer de pele e para diminui??o dos sinais do fotoenvelhecimento cut?neo.
| Identifer | oai:union.ndltd.org:IBICT/oai:tede2.pucrs.br:tede/7613 |
| Date | 29 February 2016 |
| Creators | Selbach, Sarah Ledur |
| Contributors | Kreutz, Fernando Thom?, Corte, Temis Weber Furlanetto |
| Publisher | Pontif?cia Universidade Cat?lica do Rio Grande do Sul, Programa de P?s-Gradua??o em Biotecnologia Farmac?utica, PUCRS, Brasil, Faculdade de Farm?cia |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da PUC_RS, instname:Pontifícia Universidade Católica do Rio Grande do Sul, instacron:PUC_RS |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 2304961219518893267, 500, 500, 600, -8380654636843378116, 6997636413449754996 |
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