Tumorigenesis is a multistep process, during which cells acquire a series of mutations
that lead to unrestrained cell growth and proliferation, inhibition of cell differentiation, and evasion
of cell death. Growing tumors stimulate angiogenesis, providing them with nutrients and oxygen.
Ultimately, tumor cells invade the surrounding tissue and metastasize; a process responsible for
about 90% of cancer-related deaths. Adhesion G protein-coupled receptors (aGPCRs) modulate the
cellular processes closely related to tumor cell biology, such as adhesion and detachment, migration,
polarity, and guidance. Soon after first being described, individual human aGPCRs were found to be
involved in tumorigenesis. Twenty-five years ago, CD97/ADGRE5 was discovered to be induced
in one of the most severe tumors, dedifferentiated anaplastic thyroid carcinoma. After decades of
research, the time has come to review our knowledge of the presence and function of CD97 in cancer.
In summary, CD97 is obviously induced or altered in many tumor entities; this has been shown
consistently in nearly one hundred published studies. However, its high expression at circulating
and tumor-infiltrating immune cells renders the systemic targeting of CD97 in tumors difficult.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:87359 |
| Date | 10 October 2023 |
| Creators | Aust, Gabriela, Zheng, Leyu, Quaas, Marianne |
| Publisher | MDPI |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 1538, 10.3390/cells11091538 |
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