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Previous issue date: 2016-09-19 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / The Myrtaceae family comprises more than 3,500 species, which are widely distributed on all continents (except Antarctica). The chemical diversity and the biological potential of essential oils extracted from fresh leaves of Myrtaceae species cultivated in the Botanical Garden of UFRRJ were described. Six different species were studied: Eugenia uniflora L. (?pitanga?), Eugenia brasiliensis L. (?grumixama?), Psidium cattleianum Sabine (?ara???), Psidium guajava L. (?goiaba?), Syzygium cumini (?jamel?o?) and Syzygium malaccense (L.) (?jambo?). Chemical, statistical and biological methods were used, with the aid of chromatographic analysis (GC-FID and GC-MS), chemometrics (PCA and HCA statistical analysis) and biological activities (larvicide, trypanocidal, fungicidal and antioxidant) to determine these essencial oils. The essential oil of species E. uniflora L, E. brasiliensis, P.cattleianum and P. guajava showed mainly sesquiterpenes in its compositions, while the oil from S. cumini was rich in monoterpenes and S. malaccense presented, mostly, chemical constituents not derived isoprene metabolites.. The chemometric analysis of GC-MS data of the oils extracted from leaves of six species, discriminated three groups of essential oils, according to the similarity of the composition of volatile components for each species. Specifically, for the P.cattleianum and P. guajava data, the ?-caryophyllene and ?-humuleno constituents could be considered markers of Psidium genus. The biological results suggested that the essential oils of the species studied were effective as they showed larvicide and fungicidal activity . The essential oil of E. uniflora and its isolated furanodiene showed antioxidant activity, with the TBARS method, and also showed potential anti-Trypanosoma cruzi activity, which suggests that both are an interesting alternative to combat infectious diseases such as Chagas disease / A fam?lia Myrtaceae compreende mais de 3.500 esp?cies, que est?o amplamente distribu?das por todos os continentes (exceto Ant?rtida). Este trabalho descreve a diversidade qu?mica e o potencial biol?gico dos ?leos essenciais extra?dos de folhas frescas de esp?cies de Myrtaceae cultivadas no Jardim Bot?nico da UFRRJ. Seis esp?cies diferentes foram estudadas: Eugenia uniflora L.(pitangueira), Eugenia brasiliensis Lam (grumixameira), Psidium cattleianum Sabine (ara?azeiro), Psidium guajava L. (goiabeira), Syzygium cumini (jameleiro) e Syzygium malaccense (L.) Merr. & L. M. Perry (jambeiro vermelho). Os seus ?leos essenciais foram extra?dos por hidrodestila??o e avaliados com o aux?lio de an?lises cromatogr?ficas (CG-DIC e CG-EM), quimiometria (utilizando An?lise de Componentes Principais - ACP e An?lise de Agrupamentos Hier?rquicos ? AAH) e atrav?s de atividades biol?gicas (larvicida, tripanocida, fungicida e antioxidante). O ?leo essencial das esp?cies E. uniflora L, E. brasiliensis P.cattleianum e P. guajava apresentou, principalmente, sesquiterpenos em sua composi??o, enquanto o ?leo de S. cumini foi rico em monoterpenos e o de S. malaccense apresentou constituintes qu?micos n?o oriundos de metab?litos do isopreno. Os resultados obtidos atrav?s da quantifica??o e identifica??o qu?mica dos ?leos essenciais por Cromatografia em Fase Gasosa acoplada a Espectrometria de Massas (CG-EM) aplicadas ?s an?lises quimiom?tricas permitiu discriminar tr?s agrupamentos de ?leos essenciais, de acordo com a similaridade na composi??o de constituintes vol?teis para cada esp?cie. Especificamente para P. cattleianum e P. guajava os constituintes ?-cariofileno e ?-humuleno foram considerados os marcadores do g?nero Psidium. Para os ensaios biol?gicos realizados, os resultados obtidos com os ?leos essenciais das esp?cies estudadas mostraram-se eficazes quanto ? atividade larvicida e fungicida. O ?leo essencial de E. uniflora e o furanodieno isolado apresentaram atividade antioxidante pelo m?todo TBARS, e tamb?m apresentaram potencial atividade tripanocida, sugerindo que ambos sejam uma alternativa interessante para combater doen?as parasit?rias como a doen?a de Chagas
| Identifer | oai:union.ndltd.org:IBICT/oai:localhost:jspui/1971 |
| Date | 19 September 2016 |
| Creators | Santos, Frances Regiane dos |
| Contributors | Castro, Rosane Nora, Braz Filho, Raimundo, Martins, Roberto Carlos Campos, Silva, Fernando Catinguiba da, Fernandes, Maria do Carmo de Ara?jo, Souza, Marco Andr? Alves de |
| Publisher | Universidade Federal Rural do Rio de Janeiro, Programa de P?s-Gradua??o em Qu?mica, UFRRJ, Brasil, Instituto de Ci?ncias Exatas |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da UFRRJ, instname:Universidade Federal Rural do Rio de Janeiro, instacron:UFRRJ |
| Rights | info:eu-repo/semantics/openAccess |
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