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Previous issue date: 2015-04-30 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico - CNPq / Sabe-se que o grupo das catecolaminas ? integrado pela dopamina, noradrenalina e
adrenalina e que a s?ntese dessas subst?ncias se d? de modo sequencial, sendo a enzima
tirosina-hidroxilase reguladora da fase inicial deste processo. Neste sentido, a 3-
hidroxitiramina/dopamina ? precursora da s?ntese de noradrenalina e adrenalina e ainda
possui a capacidade de atuar como neurotransmissor na por??o central do sistema
nervoso. Os tr?s principais n?cleos dopamin?rgicos, chamados zona retrorubral (grupo
A8), subst?ncia negra pars compacta (grupo A9) e ?rea tegmentar ventral (grupo A10),
est?o dispostos na por??o die-mesencef?lica e est?o envolvidos em tr?s vias, a
mesostriatal, mesol?mbica e mesocortical. Estas vias est?o relacionadas diretamente
com diversas manifesta??es comportamentais como controle da motricidade,
sinaliza??o de recompensa na aprendizagem comportamental, motiva??o e nas
manifesta??es patol?gicas da Doen?a de Parkinson e esquizofrenia. Considerando-se a
relev?ncia desses, o objetivo do trabalho foi caracterizar morfologicamente os n?cleos
dopamin?rgicos (A8, A9 e A10) do sagui (Callithrix jacchus) mediante estudo
citoarquitet?nico e imunoistoqu?mico contra tirosina-hidroxilase. O sag?i ? um primata
neotropical, cujas caracter?sticas morfofuncionais repercutem na adequabilidade de uso
deste animal em pesquisas de ordem biom?dica. Sec??es coronais dos enc?falos de seis
animais foram submetidas ? colora??o pelo m?todo de Nissl e immunoistoqu?mica para
tirosinsa-hidroxilase. Com base na morfologia dos neur?nios, foi poss?vel subdividir o
grupo A10 em sete regi?es: n?cleo interfascicular, linear rostral e linear caudal, situados
na linha m?dia; paranigral e o parainterfascicular, situados na zona intermedi?ria; a
por??o rostral da ?rea tegmentar ventral e o n?cleo parabraquial pigmentado, situados
na por??o dorsolateral do tegmento mesencef?lico. O grupo A9 foi subdividido em
quatro regi?es: subst?ncia negra camadas dorsal e ventral; subst?ncia negra conjuntos
lateral e medial. Por ?ltimo, n?o foram indentificadas subdivis?es no grupo A8.
Conclu?-se que A8, A9 e A10 s?o filogeneticamente conservados entre as esp?cies,
por?m percebe-se a necessidade de se ampliar os estudos acerca das organiza??es
subnucleares, seja investigando a sua ocorr?ncia em outras esp?cies de primatas, seja
investigando a sua relev?ncia funcional. / It is known that the catecholamine group is constituted by dopamine, noradrenaline and
adrenaline, in which the synthesis is regulated by an enzyme named tyrosine
hydroxylase. Thus, 3-hydroxytyramine/dopamine (DA) is a precursor of the
noradrenaline and adrenaline synthesis and acts as a neurotransmitter in the central
nervous system. The three main nuclei, named the retrorubral field (A8 group), the
substantia nigra pars compacta (A9 group) and the ventral tegmental area (A10 group),
are arranged in the die-mesencephalic portion and are involved in three complexes
circuitries - the mesostriatal, mesolimbic and mesocortical pathways. These pathways
are related to behavioral manifestations, motricity, learning, reward and pathologies
such as Parkinson?s Disease and Schizophrenia. Thus, the aim of this study was to
perform de morphological analysis of the A8, A9 and A10 nuclei of the common
marmoset (Callithrix jacchus). The marmoset is a neotropical primate, whose
morphological and functional characteristics supports the suitability of use of this
animal in biomedical research. Coronal sections of the marmoset brain were submitted
to cytoarchitectonic characterization and TH-immunohistochemistry. Based on the
morphology of the neurons, it was possible to subdivide the A10 group in seven
regions: interfascicular nucleus, raphe rostral linear nucleus and raphe caudal linear
nucleus, in the middle line; paranigral and parainterfascicular nucleus, in the middle
zone; rostral portion of the ventral tegmental area nucleus and parabrachial pigmented
nucleus, located in the dorsolateral portion of the mesencephalic tegmentum. A9 group
was divided into four regions: substantia nigra compacta dorsal and ventral tiers;
substantia nigra compacta lateral and medial clusters. No subdivisions were founded
into A8 group. These results revealed that A8, A9 and A10 are phylogenetically
conserved between species, but it?s necessary to expand the studies about this
compartmentalization, investigating its occurrence in other primate species or
investigating its functional relevance.
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/20231 |
| Date | 30 April 2015 |
| Creators | Cavalcanti, Jos? Rodolfo Lopes de Paiva |
| Contributors | 70317232487, http://lattes.cnpq.br/2378505945149958, Gavioli, Elaine Cristina, 97013390968, http://lattes.cnpq.br/1759328747578795, Freire, Marco Aur?lio de Moura, 61482358204, http://lattes.cnpq.br/0278347747929096, Santana, Maxwell Barbosa de, 69394083200, http://lattes.cnpq.br/5049355107877753, Engelberth, Rovena Clara Galv?o Janu?rio, 05189619400, http://lattes.cnpq.br/3745470149540939, Cavalcante, Jeferson de Souza |
| Publisher | Universidade Federal do Rio Grande do Norte, PROGRAMA DE P?S-GRADUA??O EM PSICOBIOLOGIA, UFRN, Brasil |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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