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Predictors of Muscle Function in Hemodialysis Patients

Decreased skeletal muscle function (MF) is ubiquitous in hemodialysis (HD) patients and linked to functional decline. Serum vitamin D (25-OHD) and habitual physical activity (PA) are decreased in HD and linked to reduced MF in other populations. The associations between 25-OHD, PA, and MF were investigated in 81 stable HD patients. PA intensity was quantified using accelerometery, MF using handgrip strength dynamometery, 25-OHD via serum measures, and dietary and supplementation of vitamin D intake via three-day food records. MF correlated with PA (r =0.411, p = 0.003) when controlled for body mass (BM) and with 25-OHD (r =0.298, p = 0.023) when controlled for BM, age, and sex. Both MF (r=0.285, p=0.025) and 25-OHD (r=0.314, p=0.005) correlated with vitamin D supplementation. MF remained correlated with supplementation after controlling for 25-OHD (r=0.269, p=0.037). These findings should be further explored in interventional studies to assess how their manipulation influences MF in HD.

Identiferoai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/35650
Date15 July 2013
CreatorsMahdavi, Sara
ContributorsAmara, Catherine
Source SetsUniversity of Toronto
Languageen_ca
Detected LanguageEnglish
TypeThesis

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