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Previous issue date: 2016-12-13 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / This work describes the isolation and structural determination of special metabolites isolated from leaf and stem of J. wasshauseniana (Acanthaceae), popularly known as a coati tail, which was collected in the Paracambi, RJ; Leaves and stem of T. acutifolia (Malpighiaceae), popularly known as cip?-ro?o, were collected in the Barra do Pira?-RJ and leaf and bark of L. lactescens (Malpighiaceae), popularly known as lain of lold, was collected on the campus of the Federal Rural University of Rio de Janeiro Campus Serop?dica RJ. Some chemical and biological activities of extracts of the last species were evaluated.
Chromatographic fractionation of leaf and stem extracts from the Justicia wasshauseniana (Acanthaceae), from the leaf and stem of Tetrapterys acutifolia (Malpighiaceae), and from the leaves and bark of Lophanthera lactescens (Malpighiaceae) besides analysis of fractions by chromatographic and spectroscopic techniques led to the isolation and identification of constituents of different classes of special metabolites. including new alkaloids from J. wasshauseniana.
From the leaves and stem of J. wasshauseniana were identified a triglyceride with the unsaturated acyl moiety, an unsaturated carboxylic acid, a mixture of steroids (?-Sitosterol, estigmasterol and campesterol) and glycosyl steroids (3-O-?-D-glucopyranosylsitosterol and 3-O-?-D-glucopyranosylstgmasterol), a disaccharide (?-D-glucopyranosyl-O-?-D-fructofuranoside (Sucrose) and the alkaloids acid (N-fenil-o-metileno-O-5)-3-hidroxi-5-carboxy??-lactam, and N(fenil-o-metileno-O-5)-3-hidroxi-5-(carboxilato de 2,3-dihidroxipropionila)-?-lactama), described for the first time in the literature. From the leaves and stem of T. acutifolia were identified a mixture of sitosterol, stigmasterol, 5,6-dihydro-sitosterol. and 5,6-dihydro-20-21,22-23,24-28,25-26-campesterol, ascorbic acid, in addition to sucrose and an ecdysteroid, 2S,3R,5R,9R,10R,13R,14S,17S,20S-2,3,14,20,24,25-hexahidroxicolest-7-en-6-ona (Pinatasterone). The extracts from the leaves and barks of L. lactescens, besides the mixture of sitosterol, stigmasterol and campesterol, was isolated the nortriterpene known as coreolidene. Besides to confirm the structure correction proposed in the literature of this nortriterpene, the absolute stereochemistry was defined as methyl 4R,5R,6R,7S,8S,9S,10S,13R,14S,15S,16R,17S,18R,21S,22S-friedelan-1,2-en-3-carboxy-24- 5- [1-acetoxy-ethylidene] -6,7,15,16-tetracetoxy-18-hydroxy-21,22-oxy-29-methylene-30-carboxylate. The structures were defined through analysis of IR, 1D and 2D NMR, mass spectra and circular dichroism besides some methyl and acetyl derivatives. The methanolic extracts from the stem and leaves of J. wasshausseniana and the methanolic extracts and fractions of the stem and leaves of T. acutilfolia were tested against the free radicals of DPPH. The extract from the stem of J. wasshausseniana was more active than leaf extract. The fraction of hexane from the leaves of T. acutilfolia did not present a good antioxidant activity, a greater activity was observed for the ethyl acetate fraction of stem and leaves of this plant. The pharmacological tests of the antinociceptive and anti-inflammatory potentials of the L. lactescens bark methanolic extract and the methanolic extract of leaves of J. wassahueniana were carried out, in which they showed positive results in the tested activities. / Este trabalho descreve o isolamento e determina??o estrutural de metab?litos especiais isolados de folhas e caule de J. wasshauseniana (Acanthaceae), vulgarmente conhecida como rabo de quati, que foi coletada no Munic?pio de Paracambi, RJ; folhas e caule de T. acutifolia, conhecida vulgarmente como cip?-ru?o, coletado no munic?pio de Barra do Pira?-RJ e L. lactescens (Malpighiaceae), conhecida vulgarmente como Chuva-de-Ouro, coletado no campus da Universidade Federal Rural do Rio de Janeiro Campus Serop?dica RJ. Realizaram-se testes de atividade biol?gica de extratos das duas ?ltimas esp?cies.
O fracionamento cromatogr?fico dos extratos de folhas e caule de Justicia wasshauseniana (Acanthaceae), de folhas e caule de Tetrapterys acutif?lia (Malpighiaceae), de folhas e cascas de Lophanthera lactescens (Malpighiaceae) e an?lise das fra??es atrav?s de t?cnicas cromatogr?ficas e espectrosc?picas conduziu ao isolamento e identifica??o de constituintes de diferentes classes de metab?litos especiais. Das folhas e caule de J. wasshauseniana foram identificados um triglicer?deo com a unidade acila insaturada, um ?cido carbox?lico insaturado, uma mistura dos ester?ides (?-sitostesterol, estigmasterol e campesterol) e a mistura de esteroides glicosilados, 3-O-?-D-glicopiranosilsitosterol e o 3-O-?-D-glicopiranosilestigmasterol, um dissacar?deo, ?-D-glicopiranosil-?-D-frutofuranos?deo (sacarose) e os alcal?ides ?cido-(N-fenil-o-metileno-O-5)-3hidroxi-5-carboxi??-lactama e N(fenil-o-metileno-O-5)-3-hidroxi-5-(carboxilato de 2,3-dihidroxipropionila)-?-lactama) que est?o sendo descritos pela primeira vez na literatura. Dos extratos de folhas e caule de T. acutifolia foram isolados uma mistura dos esteroides, sitostesterol, estigmasterol, 5,6-diidro-sitosterol e 5,6-diidro-20-21,22-23,24-28,25-26-octaidro-campesterol, o ?cido asc?rbico, al?m da sacarose e o ecdisteroide 2S,3R,5R,9R,10R,13R,14S,17S,20S-2,3,14,20,24,25-hexahidroxicolest-7-en-6-ona (Pinatasterona), desta enona que foi convertido em 2,3,24,25-tetraacetato atrav?s de tratamento com anidrido ac?tico e piridina. Dos extratos de folhas e cascas de L. lactescens, al?m da mistura de esteroides sitoesterol, estigmasterol e campesterol, foi isolado o nor-triterpeno conhecido como correolideo que, al?m da confirma??o da corre??o da estrutura registrada na literatura foi proposta a estereoqu?mica absoluta, sendo, entretanto definida como 4R,5R,6R,7S,8S,9S,10S,13R,14S,15S,16R,17S,18R,21S,22S-friedelan-1,2-en-3-carboxi-24-O-metileno-5-[1-acetoxi-etilideno]-6,7,15,16-tetracetoxi-18-hidroxi-21,22-oxi-29-metileno-30-carboxilato de metila. As estruturas foram definidas atrav?s de an?lise de espectros de IV, RMN 1D e 2D, massas e dicro?smo circular e, em alguns casos da prepara??o de derivados. Os extratos metan?licos de caule e de folhas de J. wasshausseniana e os extratos metan?licos e fra??es do caule e folhas de T. acutilfolia foram testados contra os radicais livres de DPPH. O extrato do caule de J. wasshausseniana apresentou melhor atividade do que o extrato de folhas. A fra??o de hexano de folhas de T. acutilfolia n?o apresentou uma boa atividade antioxidante, observando-se uma maior atividade para a fra??o de acetato de etila de caule e folhas. Realizaram-se os testes farmacol?gicos do potencial antinociceptivo e anti-inflamat?rio do extrato metan?lico de cascas de L. lactescens e extrato metan?lico de folhas de J. wassahueniana, no qual apresentaram resultados positivos nas atividades testadas
| Identifer | oai:union.ndltd.org:IBICT/oai:localhost:jspui/2021 |
| Date | 13 December 2016 |
| Creators | Fernandes, Renata Duarte |
| Contributors | Braz Filho, Raimundo, Carvalho, M?rio Geraldo de, Suzart, Luciano Ramos, Oliveira, Marcia Cristina de, Riger, Cristiano Jorge, Martins, Roberto Carlos Campos, Velozo, Leosvaldo Salazar Marques, Maleck, Marize |
| Publisher | Universidade Federal Rural do Rio de Janeiro, Programa de P?s-Gradua??o em Qu?mica, UFRRJ, Brasil, Instituto de Ci?ncias Exatas |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da UFRRJ, instname:Universidade Federal Rural do Rio de Janeiro, instacron:UFRRJ |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | AGBOR, G. A.; LONGO, F.; MAKONG, E. A. AND TARKANG, P. A. Evaluation of the antidiarrheal and antioxidant properties of Justicia hypocrateriformis. Pharm Biol,; 52(9): 1128?1133, 2014 AL-JUAID, S.S.; ABDEL-MOJIB, M.A. A novel podophyllotoxin lignan from Justicia heterocarpa. Chem Pharmaceult Bull 52: 507-509. 2004 ALONSO-CASTRO, A.J.; VILLARREAL, M.L.; SALAZAR-OLIVO, L.A.; GOMEZ-SANCHEZ, M.; DOMINGUEZ, F.; GARCIA-CARRANCA, A. Mexican medicinal plants used for cancer treatment: pharmacological, phytochemical and ethnobotanical studies. J Ethnopharmacol 133: 945-972. 2011. ANGONESE, M.T.; MOREIRA, D.L.; KAPLAN, M.A.C, Perfil qu?mico da fam?lia acanthaceae. Bol Mus Biol Mello Leit?o 1: 3-6. 1992 BABU, G. V. R.; KAVITHA, J.; SUBBARAJU, G. V. Justicia lignans: Part 8 ? Lignans from Justicia orbiculata Wall. Indian Journal of Chemistry Vo. 40B, pp 864-866. September 2001 BADAMI, S.; ANEESH, R.; SANKAR, S.; SATHISHKUMAR, M.N.; SURESH, B.; RAJAN, S. Antifertility activity of Derris brevipes variety coriacea. J Ethnopharmacol 84: 99-104. 2003 BRAGA, R. Plantas do Nordeste especialmente do Cear?. Imprensa Oficial, 3? edi??o, Fortaleza, 1976. CABRE?, P. Actividad optica, dispersion rotat?ria optica y dicro?smo circular em qu?mica org?nica. Programa Regional de Desarollo Cientifico y Tecnologico. Departamento de Asuntos Cient?ficos, Secretar?a General de la Organizaci?n de los Estados Unidos Americanos. Washington, C.C., 1974 C?CERES-CORT?S, J.R.; CANT?-GARZA, F.A.; MENDOZA-MATA, M.T.; CHAVEZ-GONZ?LEZ, M.A.; RAMOS-ANDUJANO, G.; ZAMBRANO-RAM?REZ, I.R. Cytotoxic activity of Justicia spicigerais inhibited by bcl-2 proto-oncogene and inducesapoptosis in a cell cycle dependent fashion. Phytother Res 8: 691-697. 2001 81 CASSANI, J.; DORANTES-BARR?N, A. M.; NOVALES, L. M.; REAL, G. A.;AND ESTRADA-REYES, R. Anti-Depressant-Like Effect of Kaempferitrin Isolated from Justicia spicigera Schltdl (Acanthaceae) in Two Behavior Models in Mice: Evidence for the Involvement of the Serotonergic System. Molecules 19, 21442-21461; 2014 CORREA, P. M. Dicion?rio de plantas ?teis do Brasil e das ex?ticas cultivadas. Minist?rio da Agricultura, Instituto Brasileiro de Desenvolvimento, Florestal, Brasil 5, pag. 474?475,1984. CORR?A, G. M. E ALC?NTARA, A. F. DE C. Chemical constituents and biological activities of species of Justicia - a review Brazilian Journal of Pharmacognosy 22(1): 220-238, Jan./Feb. 2012 CORR?A, G. M.; ABREU, V. G. DA C.; MARTINS, D. A. DE A.; TAKAHASHI, J. A.; FONTOURA, H. DE S.; CARA, D. C.; PIL?-VELOSO, D.; ALC?NTARA, A. F. DE C.Anti-inflammatory and antimicrobial activities of steroids and triterpenes isolated from aerial parts of Justicia acuminatissima (Acanthaceae). Int J Pharm Pharm Sci, Vol 6, Issue 6, 75-81, 2014 DAY, S.; CHIU, N.; WON, S.; LIN, C. Cytotoxic lignans of Justicia ciliata. J Nat Prod 62: 1056-1058. 1999 DEWICK, P. M. Medicinal Natural Products ? A Biosynthetic Approach (Second Edition), John Wiley & Sons Ltd, 2001. FUKAMIYA, N. & LEE, K. Antitumor agents, 81. Justicidin-A and diphyllin, two cytotoxic principles from Justicia procumbens. J Nat Prod 49: 348-350. 1986 HUI, H.Y.; CHANG, C.J.; MCLAUGHLIN, J.L.; POWELL, G.P. Justicidin B, a bioactive trace lignan from the seeds of Sesbania drummondii. J Nat Prod 49: 1175-1176. 1986 JAIN, P.S. AND BARI, S.B. Isolation of Lupeol, Stigmasterol and Campesterol from Petrleum Ether Extract of Woody Srem of Wrightia tinctoria. Asian Journal of Plant Sciences 9 (3): 163-167, 2010 82 JHA, A.; NAIDU, A. B. AND ABDELKHALIK, A. M. Transition metal-free one-pot cascade synthesis of 7-oxa-2-azatricyclo[7.4.0.02,6]trideca-1(9),10,12-trien-3-ones from biomass-derived levulinic acid under mild conditions Org. Biomol. Chem., 11, 7559-7565. 2013 JHA, D. K.; PANDA, L.; RAMAIAH, S. AND ANBARASU, A. Evaluation and Comparison of Radical Scavenging Properties of Solvent Extracts from Justicia adhatoda Leaf Using DPPH Assay. Appl Biochem Biotechnol 174:2413?2425. 2014 JOHNE, S.; WAIBLINGER, K.; GROEGER, D. Biosynthesis of quinazoline alkaloid peganine in Adhatoda vasica. Pharmazie (1973), 28, (6), 403-6. KAUR, A.; KAUR, D. AND ARORA, S. Evaluation of antioxidant and antimutagenic potential of Justicia adhatoda leaves extract. African Journal of Biotechnology Vol. 14(21), pp. 1807-1819, 27 May, 2015 KIREN, Y.; DEGUCHI, J.; HIRASAWA, Y.; MORITA, H. AND PRAJOGO, B. Justidrusamides A?D, new 2-aminobenzyl alcohol derivatives from Justicia gendarussa. J Nat Med. 68:754?758, 2014 KPOVIESSI, S.; GBAGUIDI, F.; GBENOU, J.; ACCROMBESSI, G.; HADDAD, M., MOUDACHIROU, M.; QUETIN-LECLERCQ, J. Allelopathic effects on cowpea (Vigna unguiculata (L.) Walp) plant and cytotoxic activities of sterols and triterpenes isolated from Justicia anselliana (NEES) T. Anders. Electron J Nat Subs 1: 12-19. 2006. MARTINS, L. G. S.; SENNA-VALLE, L. e PEREIRA, N. A. Princ?pios ativos e atividades farmacol?gicas de oito plantas popularmente conhecidas por nome de medicamentos comerciais. Revista Bras. PL. Med. Butucatu, Vol. 7, n?2, pag.: 73-76, 2005 MORAIS, S. M.; DANTAS, J. D?ARC P.; SILVA, A. R. A. e MAGALH?ES, E. F. Plantas medicinais usadas pelos ?ndios Tapebas do Cear?. Revista Brasileira de Farmacognosia. Brazilian Journal of Pharmacognosy, Vol.15, n?2, p?g. 169-177, Abr./Jun. 2005 POUCHERT, C. AND BEHNKE, J. Aldrich Library of 13C and 1H FT-NMR Spectra volume I-III. USA: Wisconsin. Aldrich Chemical Co 23,392-7. 1993 83 PROFICE, S.R.; KAMEYAMA, C.; C?RTES, A.L.A.; BRAZ, D.M.; INDRIUNAS, A.; VILAR, T.; PESSOA, C.; EZCURRA, C.; Wasshausen, D. Acanthaceae in Lista de Esp?cies da Flora do Brasil. Jardim Bot?nico do Rio de Janeiro. Dispon?vel em: <http://floradobrasil.jbrj.gov.br/jabot/floradobrasil/FB33> Acesso em: 02 Fev. 2016 RAGHAVENDRA, M. P.; PRASAD, A. G. DEVI AND SHYMA, T. B. Investigations on anti-diabetic medicinal plants used by tribes of Wayanad District, Kerala IJPSR; Vol. 6(8): 3617-3625., 2015 REDDY, Y. S.; CHINNALA, K. M.; NATH, K. V. S.; MOHAN, E. M.; PREETHI, B. AND NARENDER, B. In vitro evaluation of anti-oxidant activity of different extracts of Justicia gendarussa leaf. Der Pharma Chemica,7(8):21-24. 2015 ROCHA, D. Formul?rio terap?utico de plantas medicinais cearenses, nativas e cultivadas. Progresso, Fortaleza, 1945. SOUZA, V. C. e LORENZI H. Bot?nica Sistem?tica: guia ilustrado para identifica??o das fam?lias de Angiospermas da flora brasileira, baseado em APGII/Vinicius Castro Souza, Harri Lorenzi ? Nova Odessa, SP. Instituto Plantarum, 2005. SUSPLUGAS, S.; VAN HUNG, N.; BIGNON, J.; THOISON, O.; KRUCZYNSKI, A.; S?VENET, T.; GU?RITTE, F. Cytotoxic arylnaphthalene lignans from a Vietnamese acanthaceae, Justicia patentiflora. J Nat Prod 68: 734-738. 2005 VEGA-AVILA, E.; ESPEJO-SERNA, A.; ALARCON-AGUILAR, F.; VELAZCO-LESAMA, R. Cytotoxic activity of four Mexican medicinal plants. P W Pharmacol Soc 52: 78-82. 2009 VELANDIA. J. R.; CARVALHO. M. G. de; BRAZ-FILHO. R.; WERLE. A. A. Biflavonoids and a glucopyranoside derivative from Ouratea semiserrata. Phytochem. Anal., 13, 283-292, 2002. VOGEL, A.I. Qu?mica Anal?tica Qualitativa. 5? Ed. Revisada por G. Sveha. ? S?o Paulo: Mestre Jou, 1981. WASSHAUSEN, D.C. & WOOD, J.R.I. Acanthaceae of Bolivia. Contributions from the United States. National Herbarium 49: 1-152. 2004. 84 ZAPATA-MORALES, J. R.; ALONSO-CASTRO, A. J.; DOMMINGUEZ, F.; CARRANZA-ALVAREZ, C.; CASTELLANOS, L. M. O.; MARTINEZ-MEDINA, R. M. and PEREZ-URIZAR, J. Antinociceptive Activity of an Ethanol Extract of Justicia spicigera Drug development research 77 : 180?186 (2016) ZHOU, Y.; ZHAI, Y.; JI, X.; LIU, G.; FENG, E.; YE, D.; ZHAO, L.; JIANG, H. AND LIU, H. Gold(I)-Catalyzed One-Pot Tandem Coupling/Cyclization: An Efficient Synthesis of Pyrrolo-/Pyrido[2,1-b]benzo[d][1,3]oxazin- 1-ones.Advanced Synthesis & Catalysis Volume 352, Issue 2-3, pages 373?378, February 15, 2010 ZOTTELE, L. & AOYAMA, E.M. Morfoanatomia e enraizamento de estacas caulinares de Justicia wasshauseniana Profice (Acanthaceae). Natureza on line 12 (4): 179-184.2014 DAVIS, C. C.; ANDERSON, W. R. A complete generic phylogeny of Malpighiaceae inferred from nucleotide sequence data and morphology. Am. J. Bot., 97, 2031?2048. 2010 HARADA, N. and NAKANISHI, K. A Method for Determining the Chiralities of Optically Active Glycols. Journal of the American Chemical Society 91:14 July 2, 1969. KELLERMAN, T. S.; COETZER, J. A. E NAUD?, T. W. Plant Poisonings and Mycotoxicoses of Livestock in Southern Africa. Oxford University Press, Cape Town, pag. 83-130, 1988. KOREEDA, M.; HARADA, N.; NAKANISHI, K. Exciton Chirality Method as Applied to Conjugated Enones, Esters, and Lactones. Journal of the American Chemical Society / 96:l J January 9, 1974 KRISHNA, K.L.; MRUTHUNJAYA, K. and PATEL, J. A. Antioxidant an hepatoprotective activity of leaf extract of Justicia gendarussa Burn. International Journal of Biological Chemistry 3 (3): 99-110, 2009. MAMEDE, M.C.H., SEBASTIANI, R.,ALMEIDA, R.F.,FRANCENER, A.,AMORIM, A.M.A. Malpighiaceae in Lista de Esp?cies da Flora do Brasil. Jardim Bot?nico do Rio de Janeiro. 2016. Disponivel em: <http://floradobrasil.jbrj.gov.br/jabot/floradobrasil/FB155>. Acesso em: 18 Jan. 2016 MELO, M. M.; DANTAS-BARROS, A. M. Pharmacochemistry study of Tetrapterys multiglandulosa A. Juss. (Malpighiaceae). Revista Brasileira de Toxicologia 12, (2), 55-62. Editor: (Sociedade Brasileira de Toxicologia,) CODEN: RBTOFW ISSN: 1415-2983. 1999 MOCCELINI, S. K.; DA SILVA, V.C.; NDIAYE, E.A.; SOUZA JR., P.T. Estudo fitoqu?mico das cascas das ra?zes de Zanthoxylum rigidum Humb. & Bonpl. ex Willd (Rutaceae) Quim. Nova V. 32 n1, 131-133, 2009 140 NEGI, J. S.; BISHT, V. K.; BHANDARI, A. K.; BHATT, V. P.; SINGH, P.; SINGH, N. Paris polyphylla: Chemical and Biological Prospectives From Anti-Cancer Agents in Medicinal Chemistry, 14(6), 833-839. 2014 PEIXOTO P.V., LORETTI A.P. & TOKARNIA C.H. Doen?a do peito inchado, Tetrapterys spp poisoning, brisket disease and St. George disease: a comparative study. Pesq. Vet. Bras. N? 15, pag.: 43-50, 1995 QUEIROZ, M. M. F.; QUEIROZ, E. F.; ZERAIK, M. L.; EBRAHIMI, S. N.; MARCOURT, L.;CUENDET,M.; CASTRO-GAMBOA, I.; HAMBURGER, M.; BOLZANI, V. DA S.;AND WOLFENDER, J. L. Chemical Composition of the Bark of Tetrapterys mucronata and Identification of Acetylcholinesterase Inhibitory Constituents. J. Nat. Prod., 77, 650?656, 2014 RIET-CORREA, G.; TERRA, F. F.; SCHILD, A. L.; RIET-CORREA, F. e BARROS, S. S. Intoxica??o experimental por Tetrapterys multiglanulosa (Malpighiaceae) em ovinos. Pesquisa Veterin?ria Brasileira, Vol.25, n?2, pag.: 91-96, 2005. SCHULTES, R. E. Plantae Austro-Americanae IX: Plantarum Novaum vel Natbiium Notal bivrsae. Botanical Museum Laflets 16 (8). 179-228, 1954. SOUZA, V. C. & H. LORENZI. Bot?nica sistem?tica: guia ilustrado para identifica??o das fam?lias de faner?gamas nativas e ex?ticas no Brasil, baseado em APG II: 1-704. Instituto Plantarum, Nova Odessa. 2008 STOLF, L.; GAVA, A.; VERASCHIN, M. S.; NEVES, D. S.; MONDADORI, A. J. e SCOLARI, L. S. Aborto em bovinos causado pela ingest?o de Ateleia glazioviana (Leg. Papilionoideae). Pesquisa Veterin?ria Brasileira, vol. 14, pag.: 15-18, 1994. SUKSAMRARN, A. AND SOMMECHAI, C. Ecdysteroids from Vitex pinnata. Phytochemistry, 32(2),303-6. 1993 SUKSAMRARN, A.; SOMMECHAI, C.; CHARULPONG, P.; CHITKUL, B. Ecdysteroids from Vitex canescens. Phytochemistry Volume 38, Issue 2, January 1995, Pages 473-476 SUKSAMRARN, A.; KUMPUN, S.; YINGYONGNARONGKUL B.E. Ecdysteroids of Vitex scabra stem bark. J Nat Prod. Nov;65(11):1690-2, 2002. 141 TOKARNIA, C.H., PEIXOTO, P.V.; DOEBEREINER, J.; CONSORTE, L.B. and. GAVA, A. Tetrapterys spp (Malpighiaceae), a causa de mortandades em bovinos caracterizadas por altera??es card?acas. Pesqui. Vet. Bras., 9: 23-44. 1989. TOKARNIA, C.H., PEIXOTO, P.V. & DOEBEREINER, J. Poisonous plants affecting heart function of cattle in Brazil. Pesq. Vet. Bras. 10:1-10, 1990. TOKARNIA, C. H., D?BEREINER, J. e PEIXOTO, P. V. Plantas T?xicas do Brasil. Editora Helianthus, Rio de Janeiro, pag.19-61. 2000. TRINH, T. T.; TRAN, V. S.; PORZE, A.; RIPPERGER, H.; ADAM, G. Study on chemical constituents of Vitex leptobotrys. I. The ecdysteroids Tap Chi Hoa Hoc, 37, (1), 16-22. 1999 WATSON, L. e DALLWITZ, M. J. The families of Flowering Plants: Descriptions, Illustrations, Identification, Information Retrieval, 1992. Site: http://delta-intkey.com/angio/acessado em 16 de janeiro de 2010. ZHANG, Z. L.; ZUO, Y. M.; CAI, M. T.; WANG, Y. Y. Chemical constituents in roots and rhizomes of Trillium tschonoskii (II) Zhongcaoyao, 44, (20), 2808-2811. 2013 ABREU, H.S. Estudos dos constituintes qu?micos da esp?cie from Lophanthera lactescens Ducke. Tese de doutorado: UFRRJ/ICE-PPGQO, 1985 ABREU, H. S.; FO R. B.; GOTTLIEB H. E.; SHOOLERY J. N. A Nor-triterpenoid from Lophantera Lactescens. Phytochemistry, v. 29, n 7, p. 2257 ? 2261, 1990. BAO, J.; BAKER, R. K.; DOSS, G. A.; KAYSER, F.; KOTLIAR, A.; MIAO, S.; PARSONS, W. H.; RUPPRECHT, K. M. Novel Fragmentation Reacton of Correolide. Organic Letters Vol. 4, Issue 11, 1871-1873, 2002. CAMACHO, M. del R.; PHILLIPSON, J. D.; CROFT, S. L.; MARLEY, D.; KIRBY, G. C.; WARHURST, D. C. Assessment of the Antprotozoal Activity of Galphimia glauca and the Isolation of New Nor-secofriedelanes and nor-friedelanes. J. Nat. Prod. Vol.65, 1457-1461, 2002. DANELLI, M.G.M.; SOARES, D.C.; ABREU, H.S.; PE?ANHA, L.M.T.; SARAIVA, E.M. Leishmanicidal effect of LLD-3 (1), a nor-triterpene isolated from Lophanthera lactescens. Phytochemistry 70 608-614, 2009. DEWICK, P. M. Medicinal Natural Products ? A Biosynthetic Approach (Second Edition), John Wiley & Sons Ltd, 2001. DOS SANTOS, G. C. M.; FERNANDES, R. D.; BARROS, T. R.; ABREU, H. S.; SUZART, L.R.; DE CARVALHO, M. G.; BRAZ FILHO, R.; MARINHO, B. G. Antinoceptive and Anti-inflamatory Activities of the Methanolic Extract from the Stem Bark of Lophanthera lactescens. Planta Medica, v. 1, p-1-9, 2015. GOETZ, M. A.; HENSENS, O. D.; ZINK, D. L.; BORRIS, R. P.; MORALES, F.; TAMAYO-CASTILLO, G.; SLAUGHTER, R. S.; FELIX, J., BALL, R.G. Potent Nor-triterpenoid Blockers of the Voltage-gated Potassium Channel Kv1.3 from Spachea correae. Tetrahedron Letters Vol.39, 2895-2898, 1998. LORENZI, R. ?rvores brasileiras: Manual de Identifica??o e Cultivo de Plantas Arb?reas Nativas do Brasil. S?o Paulo: Editora Plantarum, 1992. 233 p. 176 MAMEDE, M.C.H. 2015. Lophanthera in Lista de Esp?cies da Flora do Brasil. Jardim Bot?nico do Rio de Janeiro. Disponivel em: http://floradobrasil.jbrj.gov.br/jabot/floradobrasil/FB23509 Acesso em: 26 Jun. 2016. PAOLI, A.A.S. Morfo-anatomia de frutos e sementes de Lophantera lactescens Ducke (MALPIGHIACEAE). Rio Claro, SP. Revista Brasileira de Sementes, 19 (2): 237-243. 1997 TAKETA, A. T. C.; LOZADA-LECHUGA, J.; FRAGOSO-SERRANO, J.; M.; VILLAREL, M. L.; MIRANDA R. P. Isolation of Nor-secofriedelanes from the Sedative Extracts of Galphimia glauca. J. Nat. Prod. Vol.67, 644-649, 2004 CAMARATA, P.J., YAKSH, T.L. Characterization of the spinal adrenergic receptors mediating the spinal effects produced by the microinjection of morphine into the periaqueductal gray. Brain Res. 336(1):133?142, 1985. CEBRID, Centro Brasileiro de Informa??es sobre Drogas Psicotr?picas. Dispon?vel em http://www.cebrid.epm.br/folhetos/opio_.htm, acesso em 21/03/2015 COUTAUX, A., ADAM, F., WILLER, J.C., LE BARS, D., Hyperalgesia and allodynia: peripheral mechanisms. Joint bone spine72: 359-371. 2005. D?AMOUR, F.E., SMITH, D.L., A method for determining loss of pain sensation, J. Pharmacol. Exp. Ther 72: 74?79. 1941. DOS SANTOS, G. C. M.; FERNANDES, R. D.; BARROS, T. R.; ABREU, H. S.; SUZART, L.R.; DE CARVALHO, M. G.; BRAZ FILHO, R.; MARINHO, B. G. Antinoceptive and Anti-inflamatory Activities of the Methanolic Extract from the Stem Bark of Lophanthera lactescens. Planta Medica, v. 1, p-1-9, 2015. HUNSKAAR, S., BERGE, O.G., HOLE K,. Dissociation between antinociceptive an anti-inflammatory effects of acetylsalicylic and indomethacin in the formalin test. Pain25: 125?132. 1986. HUNSKAAR S, HOLE K. The formalin test in mice: dissociation betweeninflammatory and non-inflammatory pain. Pain 30: 103?114. 1987. LAPA, A.J., SOUCCAR, C., LIMA-LANDMAN, M.T.R., CASTRO, M.S.A., LIMA, T.C.M. M?todos de avalia??o da atividade farmacol?gica de plantas medicinais. Sociedade Brasileira de Plantas Medicinais.Porto Alegre. 2003 LE BARS, D., GOZARIU, M., CADDEN, S.W., Animal models of nociception. Pharmacological Reviews 53: 597?652. 2001. MENSOR, L. L. et al. Screening of Brazilian plant extracts for antioxidant acitivity by the use of DPPH free radical method. Phytotherapy Research, 15(2), 127-130, 2001. 202 MESQUITA, JR. D., ARA?JO, J.A.P., CATELAN, T.T.T., SOUZA, A.W.S., SILVA, N.P., ANDRADE, L.E.C., CRUVINEL, W.M., Aspectos celulares e moleculares da inflama??o. Dispon?vel em http://www.moreirajr.com.br/revistas.asp?fase=r003&id_materia=4053, acessado em 22/03/2015 MILLAN, M.J. Descending control of pain. Progress in Neurobiology. 569:1-120, 2002 MILLAN, M.J. The induction of pain: an integrative review. Progress in Neurobiology. Vol 57, pag. 1-164, 1999 NESS, T.J., GEBHART, G.F. Visceral pain: a review of experimental studies. Pain41:167?234. 1990. OLAJIDE, O., MAKINDE, J.M., AWE, S.O., Effects of the aqueous extract of Bridelia ferruginea stem bark on carrageenan-induced oedema and granuloma tissue formation in rats and mice. Journal of Ethnopharmacology. vol 66, pag.: 113-117. 1999 PARVEEN, B.U., S. ROY and A. KUMAR. Traditional uses of medicinal plants among the rural communities of Churu district in the Thar Desert, India. J. Ethnopharmacol., 113: 387-399. 2007. PERAZA, G. G., RODRIGUES, S. T., MEDEIROS, S. H. L., MUCCILLO-BAISCH, A. L., O uso de modelos animais para avaliar o potencial antinociceptivo dos produtos de origem animal. Vittalle, Rio Grande, vol 19, n? 1, pag.: 35-44, 2007 P?REZ, R. A. et al. Amino Acid Composition and Antioxidant Capacity of Spanish Honeys. Journal of Agricultural and Food Chemistry, 55, 360-365, 2007. SERENIKI, A., VITAL, M. A. B. F., A doen?a de Alzheimer: aspectos fisiopatol?gicos e farmacol?gicos, Revista de Psiquiatria do Rio Grande do Sul, vol 30, issue 1, 2008 TASSINARI, D., MASI, A., SARTORI, S., NIELSEN, I., RAVAIOLI, A. Atypical absorption of morphine sulphate through oral mucosa: an usual case of acute opioid poisoning. Journal of pain and symptom management. 10: 405-407.1995. TJOLSEN, A., BERGE, O., HUNSKAAR, S., ROSLAND, J.H., HOLE, K. The formalin test: an evaluation of the method. Pain 51: 5-17, 1992 203 VOLTARELLI, J.C. Febre e inflama??o. Medicina, Ribeir?o Preto, v. 27, n. 1/2, pag.: 7-48, jan./jun. 1994 WHITTLE, B.A. Release of a kinin by intraperitoneal injection of chemical agents in mice. J Neuropharmacol 3: 369-378. 1964. |
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