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Previous issue date: 2006 / Objetivo: Este ensaio clínico-histológico teve por meta avaliar a resposta terapêutica de dois protocolos
de reconhecida baixa morbidade em passagem única. Métodos: Pacientes com queilite actínica crônica
multicêntrica (n=40) comprovada pela microscopia foram randomicamente submetidos a dois
protocolos de laser de CO2 pulsátil através de modelo comparativo bilateral (protocolo de pulsos de 350
mJ, 3,5 W, amplitude de 0,1s versus protocolo de pulsos de 250 mJ, 5 W, amplitude de 0,05s).
Realizou-se em 26 pacientes análise comparativa dos níveis de atipia epitelial de espécimes de biópsia
entre o status quo e o período pós-operatório de ambos os protocolos e entre si. Foram avaliados outros
fenômenos do espectro da doença. Resultados: Houve presença clínica pós-operatória de lesões em
10% dos pacientes para cada protocolo e uma significante redução dos níveis de atipia epitelial
(p<0,001), por vezes completa. Conclusão: Não houve diferença de resultados entre os protocolos
estudados (p> 0,05). / Objective: This clinicohistologic assay aimed to assess the therapeutic response of two low
morbidity level protocols by a sole laser pass. Methods: Patient with multicentric and
microscopically proven chronic actinic cheilitis (n=40) were randomly submitted to two
protocols of pulsed carbon dioxide laser through a bilateral comparative model (protocol of
pulses of 350 mJ, 3.5 W, pulse width of 0.1s versus protocol of pulses de 250 mJ, 5 W, pulse width
of 0.05s). Histological comparative analysis of the epithelial atypia level was performed in 26
patients considering the status quo and the postoperative period for both protocols and
between them. Besides this central parameter, other actinic cheilitis histological phenomena
were assessed. Results: There was clinical recurrence in 10% for each protocol and a
significant reduction of epithelial atipia level (p < 0.001), sometimes completely. Conclusion:
There was no difference between both protocols (p > 0.05).
Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.unifesp.br:11600/39220 |
Date | January 2006 |
Creators | Godoy Peres, Flávio Francisco de [UNIFESP] |
Contributors | Universidade Federal de São Paulo (UNIFESP), Plapler, Hélio [UNIFESP] |
Publisher | Universidade Federal de São Paulo (UNIFESP) |
Source Sets | IBICT Brazilian ETDs |
Language | Portuguese |
Detected Language | English |
Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
Format | 78 p. |
Source | reponame:Repositório Institucional da UNIFESP, instname:Universidade Federal de São Paulo, instacron:UNIFESP |
Rights | info:eu-repo/semantics/openAccess |
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