There is evidence that a synaptic tagging and capture mechanism is involved in the creation of long-term memory during late-phase long-term potentiation (LTP). Events and contexts produce molecular tags on specific connections on the neuron cell body, which enable them to capture plasticity related proteins, PRPs created in the cell nucleus, if there is a strong event that induces the protein synthesis. This mechanism is believed to underlie behavioral tagging (BT) and infer that a molecular tag from a specific event can utilize PRPs from another event, with an effect on memory consolidation and long-term memory. We researched this through Pavlonian fear conditioning with contextual-fear, conditioned stimulus (CS) over two days, in two groups of healthy volunteers (n = 32, day 1 & n = 28, day 2). The result suggests that there is an effect on consolidation, that is, a novel navigation task on day 1 may be responsible for a strengthened recall of a fear memory that is learned one hour later. This suggests that BT effects can be produced in humans through an experimental procedure. Future research will have to test this further with more power to fully confirm if it corresponds to the truth.
| Identifer | oai:union.ndltd.org:UPSALLA1/oai:DiVA.org:uu-526607 |
| Date | January 2024 |
| Creators | Olsson, Benjamin, Persson, Edvin |
| Publisher | Uppsala universitet, Institutionen för psykologi |
| Source Sets | DiVA Archive at Upsalla University |
| Language | English |
| Detected Language | English |
| Type | Student thesis, info:eu-repo/semantics/bachelorThesis, text |
| Format | application/pdf |
| Rights | info:eu-repo/semantics/openAccess |
Page generated in 0.0614 seconds