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Previous issue date: 2015-04-10 / Diversos estudos revelam que nas ?ltimas d?cadas ocorreu uma diminui??o na
dura??o do sono. Os compromissos sociais, como o trabalho e a escola, muitas
vezes n?o est?o alinhados ao ?tempo biol?gico? dos indiv?duos. Somada a isso,
observa-se uma menor for?a do zeitgeber causada pela menor exposi??o ? luz
durante o dia e maior ? noite. Isso gera um d?bito cr?nico de sono que ?
compensado nos dias livres, ocorrendo semanalmente uma restri??o e extens?o do
sono denominada de jet lag social. A priva??o de sono vem sendo associada ?
obesidade, risco cancer?geno e cardiovascular. Desta-forma, sugere-se que o
sistema nervoso auton?mico seja um caminho que relaciona os problemas do sono
?s doen?as cardiovasculares. No entanto, al?m das evid?ncias demonstradas por
pesquisas com uso de modelos de priva??o de sono de forma aguda e controlada,
s?o necess?rios estudos investigando efeitos da priva??o do sono de forma cr?nica
como ocorre no jet lag social. O objetivo deste estudo foi investigar a influ?ncia do jet
lag social em marcadores circadianos de atividade-repouso e card?acos em
estudantes do Curso de Medicina. Trata-se de um estudo transversal e
observacional realizado no Laborat?rio de Neurobiologia e Ritmicidade Biol?gica
(LNRB) do Departamento de Fisiologia da UFRN. Participaram da pesquisa
estudantes de medicina matriculados no 1? per?odo do curso da UFRN. Foram
utilizados os seguintes instrumentos: Question?rio cronotipo de Munique (MCTQ);
Question?rio para identifica??o de indiv?duos matutinos e vespertinos (MEQ ou HO);
?ndice de qualidade do sono de Pittsburgh; Escala de Sonol?ncia de Epworth;
Act?metro; Cardiofrequenc?metro. Foram analisadas vari?veis de caracteriza??o do
sono, n?o param?tricas (IV60, IS60, L5 e M10) e ?ndices card?acos no dom?nio do
tempo, frequ?ncia (LF, HF, LF/HF) e n?o linear (SD1, SD2, SD1/SD2). Realizou-se
an?lise estat?stica descritiva, comparativa e de correla??o com uso do programa
SPSS vers?o 20. Participaram do estudo 41 estudantes, 48,8% (20) mulheres e
51,2% (21) homens, com 19,63 ? 2,07 anos. O jet lag social teve uma m?dia de
02:39h ? 00:55h, 82,9% (34) com jet lag social ? 1 hora e houve correla??o negativa
com escore cronotipo de Munique evidenciando maior priva??o do sono em
indiv?duos com tend?ncia ? vespertinidade. Qualidade do sono ruim foi detectada em
90,2% (37) (X
2
= 26,56, p < 0,001) e 56,1% (23) sonol?ncia diurna excessiva (X
2
=
0,61, p = 0,435). Observou-se diferen?a significativa dos valores de LFnu, HFnu e
LF/HF entre os grupos de jet lag social < 2h e ? 2h e houve correla??o do jet lag
social com LFnu (rs = 0,354, p = 0,023), HFnu (rs = - 0,354, p = 0,023) e LF/HF (rs =
0,355, p = 0,023). Verificou-se ainda associa??o negativa entre IV60 e ?ndices no
dom?nio do tempo e n?o lineares. Sugere-se que a priva??o cr?nica de sono pode
ter associa??o com maior atividade simp?tica promovendo aumento no risco
cardiovascular. / Studies reveal that in recent decades a decrease in sleep duration has occurred.
Social commitments, such as work and school are often not aligned to the "biological
time" of individuals. Added to this, there is a reduced force of zeitgeber caused by
less exposure to daylight and larger exposure to evenings. This causes a chronic
sleep debt that is offset in a free days. Indeed, a restriction and extent of sleep called
"social Jet lag" occurs weekly. Sleep deprivation has been associated to obesity,
cancer, and cardiovascular risk. It is suggested that the autonomic nervous system is
a pathway that connects sleep problems to cardiovascular diseases. However,
beyond the evidence demonstrated by studies using models of acute and controlled
sleep deprivation, studies are needed to investigate the effects of chronic sleep
deprivation as it occurs in the social jet lag. The aim of this study was to investigate
the influence of social jet lag in circadian rest-activity markers and heart function in
medical students. It is a cross-sectional, observational study conducted in the
Laboratory of Neurobiology and Biological Rhythmicity (LNRB) at the Department of
Physiology UFRN. Participated in the survey medical students enrolled in the 1st
semester of their course at UFRN. Instruments for data collection: Munich
Chronotype Questionnaire, Morningness Eveningness Questionnaire of Horne and
?stberg, Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale, Actimeter; Heart
rate monitor. Analysed were descriptive variables of sleep, nonparametric (IV60,
IS60, L5 and M10) and cardiac indexes of time domain, frequency (LF, HF LF / HF)
and nonlinear (SD1, SD2, SD1 / SD2). Descriptive, comparative and correlative
statistical analysis was performed with SPSS software version 20. 41 students
participated in the study, 48.8% (20) females and 51.2% (21) males, 19.63 ? 2.07
years. The social jet lag had an average of 02: 39h ? 00:55h, 82.9% (34) with social
jet lag ? 1h and there was a negative correlation with the Munich chronotype score
indicating greater sleep deprivation in subjects prone to eveningness. Poor sleep
quality was detected in 90.2% (37) (X2
= 26.56, p <0.001) and 56.1% (23) excessive
daytime sleepiness (X2
= 0.61, p = 0.435). Significant differences were observed in
the values of LFnu, HFnu and LF / HF between the groups of social jet lag <2h and ?
2h and correlation of the social jet lag with LFnu (rs = 0.354, p = 0.023), HFnu (rs = -
0.354 , p = 0.023) and LF / HF (r = 0.355, p = 0.023). There was also a negative
association between IV60 and indexes in the time domain and non-linear. It is
suggested that chronic sleep deprivation may be associated with increased
sympathetic activation promoting greater cardiovascular risk.
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/20065 |
| Date | 10 April 2015 |
| Creators | Ferreira, Luana Gabrielle de Fran?a |
| Contributors | 22800662387, http://lattes.cnpq.br/3347815035685882, Ribeiro, Sidarta Tollendal Gomes, 50591797100, http://lattes.cnpq.br/0649912135067700, Ferreira, Sionaldo Eduardo, 95230068604, http://lattes.cnpq.br/7730654028676766, Ara?jo, John Fontenele |
| Publisher | Universidade Federal do Rio Grande do Norte, PROGRAMA DE P?S-GRADUA??O EM NEUROCI?NCIAS, UFRN, Brasil |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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