Non-steroidal anti-inflammatory drugs (NSAIDs) may cause enteropathy in dogs and
probiotics may be one option to prevent this. The objective of this study was to determine whether
the administration of canine-obtained lactic acid bacteria (LAB) has an effect on the frequency of
diarrhea, the composition of the fecal microbiota, and/or markers of gastrointestinal inflammation in
dogs receiving NSAIDs when compared to dogs given NSAIDs and a placebo. A total of 22 dogs
treated with NSAIDs for various clinical indications were enrolled in a seven-day randomized,
double-blinded placebo-controlled interventional study. Dogs were randomized to receive either
placebo or LAB, a product containing Limosilactobacillus fermentum, Lacticaseibacillus rhamnosus, and
Lactiplantibacillus plantarum. Fecal samples were collected on days one and seven. The fecal microbiota
was evaluated using the fecal dysbiosis index (DI) and individual bacterial taxa. Fecal calprotectin (CP)
and S100A12/Calgranulin C concentrations were used as markers of gastrointestinal inflammation.
There was a difference in frequency of diarrhea between groups, with it affecting 4/12 dogs (33%) in
the placebo group and 1/10 dogs (10%) in the LAB group, but this difference did not reach statistical
significance (p = 0.32). There was a correlation between S100A12 and CP (p < 0.001), and Clostridium
perfringens correlated with S100A12 (p < 0.015). Neither treatment significantly affected S100A12
(p = 0.37), CP (p = 0.12), or fecal DI (p = 0.65). This study suggests that LAB is a safe supplement to
use for short-term treatment in NSAID-treated dogs, but further studies are needed to determine its
potential to prevent NSAID-induced enteropathy in dogs.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:93444 |
| Date | 27 August 2024 |
| Creators | Herstad, Kristin M. V., Vinje, Hilde, Skancke, Ellen, Næverdal, Terese, Corral, Francisca, Llarena, Ann-Katrin, Heilmann, Romy M., Suchodolski, Jan S., Steiner, Joerg M., Nyquist, Nicole Frost |
| Publisher | MDPI |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 2076-2615, 2519, 10.3390/ani12192519 |
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