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Previous issue date: 2017-06-05 / Introdu??o: O diagn?stico da sarcopenia ? restrito aqueles com boa capacidade f?sica e cognitiva, n?o sendo adaptado ?s condi??es dos idosos institucionalizados. Al?m disso, apesar da perda de massa muscular ser determinante para seu diagn?stico, redu??o associada de massa gorda tem sido observada na sarcopenia. Ademais, embora o estado inflamat?rio seja considerado um gatilho da perda de massa muscular, a redu??o no tecido adiposo tem sido associado ? redu??o do estado inflamat?rio, concorrendo no constructo te?rico da associa??o entre inflamm-aging e sarcopenia. Objetivo: Discutir o diagn?stico para sarcopenia em idosos institucionalizados e verificar a associa??o entre inflamm-aging e sarcopenia, assim como analisar seus fatores associados. Metodologia: Tr?s estudos foram conduzidos em idosos de ambos os sexos, residentes em institui??es de longa perman?ncia na cidade do Natal/RN. No estudo 1 (n=219) foi realizado uma adapta??o do Consenso Europeu para Diagn?stico da Sarcopenia (2010) agregando idosos com baixa capacidade f?sica e cognitiva. No estudo 2 (n=219) foi verificado quais os fatores est?o associados ? sarcopenia. No estudo 3 (n=187) foi realizado an?lise de conglomerados de idosos segundo seu estado inflamat?rio e verificado os fatores associados ? esta condi??o. Resultados: Inclus?o de idosos com baixa condi??o f?sica e cognitiva (estudo 1) acresceu em 32,2% a preval?ncia de sarcopenia. No estudo 2, os fatores associados ? sarcopenia foram altura do joelho, eutrofia e excesso de peso (segundo IMC) e capacidade de deambular. No estudo 3 foi poss?vel verificar que aumento de 1 unidade ?g/dL no LDL, HDL e triglicer?deos apresentaram aumento de 1,5%, 4,1% e 0,9% a chance de inflamm-aging e idosos longevos (?80 anos) possu?ram 84,9% mais de chance de inflamm-aging. Conclus?o: Inclus?o de idosos com baixa capacidade f?sica e cognitiva para c?lculo de sarcopenia ? valida e representa de modo mais adequado os idosos institucionalizados, apresentando o aspectos antropom?tricos e f?sicos como seus principais fatores associados. Ademais, os indicadores bioqu?micos e antropom?tricos demonstraram rela??o da sarcopenia com desnutri??o. Al?m disso, n?o foi observado associa??o do inflamm-aging com sarcopenia, corroborando o constructo de que na sarcopenia n?o ocorre perda seletiva da massa muscular. / Introduction: The diagnosis of sarcopenia is restricted to those with good physical and cognitive capacity, not being adapted to the conditions of the institutionalized elderly. In addition, dispite the loss of muscle mass is determinant for its diagnosis, associated reduction of fat mass has been observed in sarcopenia. Although the inflammatory state is considered a trigger to loss of muscle mass, reduction in adipose tissue has been associated with the reduction of the inflammatory state, competing in the theoretical construct of the association between inflammation and sarcopenia. Objective: To discuss the diagnosis of sarcopenia in institutionalized elderly patients and to verify the association between inflammation and sarcopenia, as well as to analyze their associated factors. Methodology: Three studies were conducted in elderly people of both sexes, living in nursing homes in the city of Natal / RN. In study 1 (n = 219) an adaptation of the European Consensus for Diagnosis of Sarcopenia (2010) was carried out, adding elderly people with low physical and cognitive capacity. In study 2 (n = 219) it was verified which factors are associated with sarcopenia. In study 3 (n = 187), the analysis of elderly conglomerates according to their inflammatory state was performed and the factors associated with this condition were verified. Results: Inclusion of elderly people with low physical and cognitive status (study 1) increased the prevalence of sarcopenia by 32.2%. In study 2, the factors associated with sarcopenia were knee height, eutrophy and excess weight (according to BMI) and the ability to ambulate. In study 3 it was possible to verify that increase of 1 unit ?g / dL in LDL, HDL and triglycerides presented a 1.5%, 4.1% and 0.9% increase in the chance of inflamm-aging and elderly individuals (?80 years ) had an 84.9% greater chance of inflammation. Conclusion: Inclusion of elderly with low physical and cognitive capacity to calculate sarcopenia is valid and represents more appropriately the institutionalized elderly, presenting the anthropometric and physical aspects as their main associated factors. In addition, the biochemical and anthropometric indicators demonstrated a relationship of sarcopenia with malnutrition. In addition, no association of inflammation with sarcopenia was observed, corroborating the construct that in sarcopenia there is no selective muscle mass loss.
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/23761 |
| Date | 05 June 2017 |
| Creators | Oliveira Neto, Le?nidas de |
| Contributors | 50337157472, http://lattes.cnpq.br/5835673385014578, Davim, Andr? Luiz Silva, 01010243470, http://lattes.cnpq.br/3809975612215286, Souza, Dyego Leandro Bezerra de, 00902557475, http://lattes.cnpq.br/9953301230987878, Elsangedy, Hassan Mohamed, 04459139910, http://lattes.cnpq.br/7777329239184430, Gomes, Igor Conterato, 33970223806, http://lattes.cnpq.br/6376387527034483, Lima, Kenio Costa de |
| Publisher | PROGRAMA DE P?S-GRADUA??O EM SA?DE COLETIVA, UFRN, Brasil |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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