Curcuminoids have strong anticancer activities but have low bioavailability. The
highest rate of cancer deaths comes from lung tumours; therefore, inhaled
curcuminoids could treat lung cancer locally. To date, there are no nebulised
formulations of curcuminoids, and there are no inhalable curcuminoids particles
without excipients using air jet mill and sonocrystallisation methods for DPI
formulations. It is the first time; the aerodynamic parameters of curcumin,
demethoxycurcumin and bisdemethoxycurcumin were measured individually
using NGI. The size, shape, free surface energy, and the crystal polymorphism
of the produced inhalable curcuminoid particles were characterised using laser
diffraction, SEM, IGC, DSC and XRPD, respectively. Several DPI formulations
with a variable particle size of curcuminoids were prepared in two drug-carrier
ratios (1:9 and 1:67.5). The best performance of the DPI formulations of the
sonocrystallised particles, which exist in crystal structure form1, were obtained
from ethanol- heptane, as illustrated FPF 43.4%, 43.6% and 43.4% with MMAD
of 3.6µm, 3.5µm and 3.4µm, whereas the best DPI formulation of the air jet
milled particles was presented FPF 38.0%, 38.9%, and 39.5% with MMAD of
3.6µm, 3.4µm and 3.2µm for curcumin, demethoxycurcumin and
bisdemethoxycurcumin, respectively.
Nebulised curcuminoids using nanoemulsion and microsuspension formulations
were prepared. The physical properties, such as osmolality, pH and the
viscosity of the aerosolised nanoemulsion and the microsuspension
formulations were determined. The FPF% and MMAD of nebulised
nanoemulsion ranged from 44% to 50% and from 4.5µm to 5.5µm respectively.
In contrast, the FPF% of microsuspension ranged from 26% to 40% and the
MMAD from 5.8µm to 7.05µm. A HPLC method was developed and validated in
order to be used in the determination of curcuminoids from an aqueous solution.
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/15324 |
| Date | January 2017 |
| Creators | Al Ayoub, Yuosef |
| Contributors | Assi, Khaled H., Paradkar, Anant R |
| Publisher | University of Bradford, School of Pharmacy |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Thesis, Doctoral, PhD |
| Rights | <a rel="license" href="http://creativecommons.org/licenses/by-nc-nd/3.0/"><img alt="Creative Commons License" style="border-width:0" src="http://i.creativecommons.org/l/by-nc-nd/3.0/88x31.png" /></a><br />The University of Bradford theses are licenced under a <a rel="license" href="http://creativecommons.org/licenses/by-nc-nd/3.0/">Creative Commons Licence</a>. |
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