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Previous issue date: 2014-09-25 / As esp?cies do g?nero Kalanchoe (Crassulaceae) s?o bastante utitlizadas em
todo o Brasil, como medicamento para tratar tosse, fur?nculos, gastrite e outras
enfermidades. Nesse cen?rio destaca-se K. brasiliensis, conhecida popularmente
como coirama ou sai?o. Este trabalho tem como proposta a exposi??o por via oral
de camundongos a um extrato hidroalco?lico de folhas de Kalanchoe brasiliensis.
Os animais (total de 100) foram divididos em grupos de 12 (6 machos e 6 f?meas)
para avalia??o aguda; e grupos de 10 para avalia??o subcr?nica.Os grupos teste
foram tratados com doses de 250 mg/Kg, 500 mg/Kg, 1000 mg/Kg e 2000 mg/Kg,
e o grupo controle recebeu solu??o salina 0,9 %. Os animais foram observados
por 14 dias para avalia??o aguda e 30 dias para avalia??o subcr?nica, e nesse
per?odo analisou-se o aparecimento de sinais cl?nicos, altera??es no peso e no
consumo de ?gua e ra??o. Ap?s o per?odo de observa??o, foram realizadas a
an?lise histopatol?gica dos ?rg?os, as concentra??es s?ricas bioqu?micas e
par?metros hematol?gicos para os grupos da avalia??o subcr?nica. N?o foram
observadas diferen?as e altera??o do peso corp?reo entre os grupos, nem de
consumo de ?gua e ra??o, tamb?m n?o houve mortes entre os grupos, nos dois
tipos de ensaios. As an?lises histopatol?gicas demonstraram algumas altera??es
compat?veis com baixa toxicidade aguda hep?tica. Os resultados de glicemia,
triglicer?deos, ALT, ureia e creatinina mostraram diferen?as entre o grupo controle
e os testes nas concentra??es estudadas (p<0,05), por?m estas diferen?as n?o
demonstram mudan?a relevante no quadro cl?nico dos animais. Os resultados
mostraram que o extrato de K. brasiliensis apresenta baixa toxicidade aguda nas
doses utilizadas e n?o apresenta toxicidade quando administrado durante 30 dias.
Isto destaca a import?ncia desta esp?cie como futuro e promissor candidato a
fitoter?pico, assim que tenha seus ensaios farmacol?gicos conclu?dos. / The species of the genus Kalanchoe (Crassulaceae) are widely used in Brazil as a
medicinal product to treat cough, boils, gastritis and other diseases. In this
scenario stands out K. brasiliensis, popularly known as coirama or sai?o. This
paper aims at the oral exposure of mice to a hydroalcoholic extract of leaves of
Kalanchoe brasiliensis. The animals (total of 100) were divided into 12 groups (6
males and 6 females) for the acute assessment; and groups of 10 for subchronic
evaluation. Test groups were treated with doses of 250 mg / kg, 500 mg / kg, 1000
mg / kg and 2000 mg / kg and the control group received 0.9% saline. The animals
were observed for 14 days for acute evaluation and 30 days for subchronic
evaluation, and in that period analyzed the appearance of clinical signs, changes
in weight and consumption of water and food. After the observation period,
histopathological analysis of the organs, biochemical serum and haematological
parameters for the assessment of the subchronic groups were processed.
Differences and changes in body weight were not observed among the groups, nor
consumption of water and food, there were no deaths among the groups in the two
types of assays. Histopathological analysis showed some alterations compatible
with low acute hepatic toxicity. The results of blood glucose, triglycerides, ALT,
urea and creatinine showed differences between the control group and the test
concentrations studied (p <0.05), but these differences do not show relevant
change in the clinical picture of animals. The results showed that the extract K.
brasiliensis has low acute toxicity at the doses used and no toxicity when
administered for 30 days. This highlights the importance of this species as future
and promising candidate for phytotherapics, so has its pharmacological trials
completed.
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/19954 |
| Date | 25 September 2014 |
| Creators | Fonseca, Aldilane Gon?alves da |
| Contributors | 70155780425, http://lattes.cnpq.br/4311626091295357, Soares, Luiz Alberto Lira, 88258033468, http://lattes.cnpq.br/4290808161139329, Kujbida, Paula da Silva, 28974955881, http://lattes.cnpq.br/2285854300593624, Langassner, Silvana Maria Zucolotto, Lemos, Telma Maria Ara?jo Moura |
| Publisher | Universidade Federal do Rio Grande do Norte, PROGRAMA DE P?S-GRADUA??O EM CI?NCIAS FARMACEUTICAS, UFRN, Brasil |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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