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cogni_al_dr_botfm.pdf: 515114 bytes, checksum: 111c598399d07d757669fa799c207de6 (MD5) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / A ocorrência de remodelação ventricular (RV) é fator preditor de má evolução após o infarto agudo do miocárdio (IAM). Alterações nas metaloproteases (MMP) 2 e 9 da matriz extracelular cardíaca estão envolvidas no desenvolvimento de RV. O objetivo deste estudo foi avaliar o papel dos níveis séricos das MMP-2 e -9 como fatores preditores de remodelação ventricular em pacientes com infarto de parede anterior após 6 meses da oclusão coronariana. Estudo prospectivo, observacional de pacientes com o primeiro episódio de IAM de parede anterior admitidos em hospital terciário entre novembro/2007 e julho/2008. A dosagem de MMP foi realizada por zimografia em amostras coletadas 12 a 72 horas após IAM. Ecocardiogramas foram realizados durante a internação hospitalar e 6 meses após alta. Foram incluídos 37 pacientes, dos quais evoluíram a óbito e 4 perderam o seguimento. Dos 29 pacientes avaliados, 18 (62,1%) apresentaram RV, definada como aumento de, pelo menos, 15% nos volumes sitólicos e/ou diastólicos... / The occurrence of ventricular remodeling (VR) is associated with poor outcome after acute myocardial infarction (AMI). Changes in cardiac matrix metalloproteinases (MMP) 2 and 9 are involved with VR development. The aim of tis study was to evaluate the role of serum matrix MMP-2 and -9 as predictors of VR in patients with anterior AMI six months after coronary occlusion. We carried out a prospective observational study of consecutive patients with first anterior AMI admitted in a tertiary hospital. MMP activity was assayed by zymography in samples collected 12 to 72 hours after AMI. Echocardiogram assessment was performed both during hospitalization and six months later. We included 37 patientes, of whom four died and four lost the follow-up. Considering the 29 patients evaluated, 18 (62.1%) had VR, defined as a minimum 15% increase of diastolic and/or systolic left ventricular volumes from baseline to six months echocardiogram. There was no statistically significant difference between groups with presence or absence of VR with respect to clinical characteristics, risk factors and treatment of AMI. On the other hand, the VR group had higher infarct size assessed... (Complete abstract click electronic access below)
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.unesp.br:11449/102640 |
| Date | 08 August 2011 |
| Creators | Cogni, Ana Lúcia [UNESP] |
| Contributors | Universidade Estadual Paulista (UNESP), Zornoff, Leonardo Antonio Mamede [UNESP], Gaiolla, Paula Schmidt Azevedo [UNESP] |
| Publisher | Universidade Estadual Paulista (UNESP) |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Format | 62 f. |
| Source | Aleph, reponame:Repositório Institucional da UNESP, instname:Universidade Estadual Paulista, instacron:UNESP |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | -1, -1, -1 |
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