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000758181.pdf: 1360078 bytes, checksum: 426974081d9d61117a57cddef7eb84c6 (MD5) / Para ampliar os conhecimentos dos efeitos do diabete na gestação e danos no DNA, foi realizada uma revisão de literatura utilizando dois conjuntos de palavras-chave: 1) diabetes, DNA damage, pregnancy e 2) rat, diabetes, DNA damage, pregnancy, no site da base de dados do National Center of Biotechnology Information (NCBI-PUBMED). No primeiro conjunto, foram encontrados 28 artigos e, no segundo, 13 artigos. Destes, 11 eram iguais aos do primeiro conjunto e dois não tinham coerência com as palavras-chave. Dos 28 artigos analisados, 28,58% foram considerados adequados para a redação da revisão e 71,42% inadequados, pois tinham títulos e resumos fora de contexto. Dos adequados, 37,5% eram relacionados à pesquisa em humanos, 50% em animais de experimentação e 12,5% em humanos e animais. De forma geral, os artigos demonstraram que o diabete aumenta espécies reativas de oxigênio gerando danos em ácidos nucleicos e isto exarceba o estresse oxidativo materno, embrionário e fetal / To contribute the knowledge of the diabetes effects during pregnancy in the DNA damage, we performed a literature review using two groups of keywords: 1) diabetes, DNA damage, pregnancy and 2) rat, diabetes, DNA damage, pregnancy, in site of the database of the National Center for Biotechnology Information (NCBI-PUBMED). In the first group of keywords were found 28 articles. In the second group, there were 13 articles, which 11 were equal to the first group. Then, 28 articles were analyzed. Of these articles, 28,28% were considered adequate for writing the review, while 71,42% were considered inappropriate because they presented no coherent titles and abstracts. Of these articles, 37.5% were related to human research, 50% in experimental animals and 12.5% in humans and animals. Thus, in general, the articles showed that diabetes increases the reactive oxygen species that causes nucleic acid damage and this exacerbates maternal, embryonic and fetal oxidative stress
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.unesp.br:11449/108604 |
| Date | 22 February 2013 |
| Creators | Oliveira Netto, Aline de [UNESP] |
| Contributors | Universidade Estadual Paulista (UNESP), Damasceno, Débora Cristina [UNESP] |
| Publisher | Universidade Estadual Paulista (UNESP) |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | Portuguese |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | 65 f. |
| Source | Aleph, reponame:Repositório Institucional da UNESP, instname:Universidade Estadual Paulista, instacron:UNESP |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | -1, -1 |
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